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| 1 | Clinical pharmacology considerations in biologics development显示文摘Biologics 包括 monoclonal 抗体(mAbs ) 和象 cytokines 和生长荷尔蒙那样的另外的治疗学的蛋白质,与小分子相比有唯一的特征。这篇论文为阶段 II/III 临床的试用从一个机械学的观点,为 first-in-human (FIH ) 的剂量学习的开始的决心,和 dosing 政体优化从 biologics 的 pharmacokinetics (PK ) 的概述开始。随后,典型临床的药理学发出相应小径因为 biologics 开发被总结,包括在特定的人口的药药相互作用, QTc 延伸, immunogenicity,和研究。在 biologics,他们的 pharmacokinetic 和 pharmacodynamic 特征,和相应临床的药理学策略的分子的结构之间的关系在一张图解的图被总结并且描绘。 | Liang ZHAO Tian-hua REN Diane D WANG | 2012 | Acta Pharmacologica Sinica2012，33，11： | 5 |
| 2 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 3 | Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy?显示文摘 | Diane Goéré David Malka Dimitri Tzanis Vinicius Gava Valérie Boige Clarisse Eveno Léon Maggiori Frédéric Dumont Michel Ducreux Dominique Elias | 2013 | Annals of Surgery2013，，6： | 2 |
| 4 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 5 | Definition of Patients Presenting a High Risk of Developing Peritoneal Carcinomatosis After Curative Surgery for Colorectal Cancer: A Systematic Review显示文摘 | Charles Honoré Diane Goéré Amine Souadka Frédéric Dumont Dominique Elias | 2013 | Annals of Surgical Oncology2013，，1： | 2 |
| 6 | Comparison of total laparo- scopic, vaginal and abdominal hysterectomy 显示文摘 | Schindlbeck C Klauser K Dian D | 2008 | Arch Gynecol Ob- stet2008，277，4： | 1 |
| 7 | Comparison of total laparoscopic,vaginal and abdominal hysterectomy显示文摘 | Schindlbeck C Klauser K Dian D | 2010 | Arch Gynecol Obstet2010，10，4： | 1 |
| 8 | Reevaluation of the structure-conduct-performance relationship in banking显示文摘 | EVANOFF DOUGLAS D DIANE FORTIER | 1988 | Journal of Financial Services Research1988，1，： | 1 |
| 9 | The 2001 Bethesda system terminology for reporting results of cervical cytology 显示文摘 | Diane S Diane D Robert K | 2002 | JAMA2002，287，： | 1 |
| 10 | Aesthetic res among breast cancer patients undergoing autologous bre reconstruction versus breast conserving therapy显示文摘 | Dian D Schwenn K Mylonas I | 2007 | Arch Gyne Obstet2007，275，6： | 1 |
| 11 | 2000, Dynamics of vegetative growth of Hevea brasiliensis in determining tapping norms 显示文摘 | Obouayeba S Boa D Gohet E Dian K Ouattara N Keli Z J | 2000 | Journal of Rubber Re- search2000，3，1： | 1 |
| 12 | Leverage and investment in diversified firms显示文摘 | Seoungpil A Denis D J Diane K D | | 0，，： | 1 |
| 13 | The 2001 Bethesda SystemTerminnology for Reporting Results of Cervical Cytology显示文摘 | Diane D Robert K | 2002 | JAMA2002，28，7： | 1 |
| 14 | Exploring tuberculosis patients' adherence to treatment regimens and prevention programs at a public health site 显示文摘 | Pamela N Judy D Diane C | 2009 | Qual Health Res2009，19，1： | 1 |
| 15 | Stress at college :Effects on health habits, health status and self- esteem显示文摘 | ]Suzanne S H Jennifer D Diane E S | 2000 | Journal of Social Psychiatry2000，43，： | 1 |
| 16 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 17 | The 2001 Bethesda System Terminology for reporting cervical of cervical cytology显示文摘 | Diane S Diane D Robert K | 2002 | JAMA2002，287，： | 1 |
| 18 | Thermal infrared anomaly precursors of impending earthquakes显示文摘 | Qiang Z J Xu X D Dian C G | 1997 | Pure and Applied Geophysics1997，149，： | 1 |
| 19 | Blood urea nitrogen concentration as a marker of amino acid intolerance in neonates with birthweight less than 1250 grams显示文摘 | Ridout E Diane Melara D Rottinghaus S | 2005 | J Perinat2005，25，： | 1 |
| 20 | Comparison of totallaparoscopic, vaginal and abdominal hysterectomy显示文摘 | Schindlbeck C Klauser K Dian D | 2008 | Arch GynecolObstet2008，277，4： | 1 |
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