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| 1 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 2 | Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes显示文摘 | Jiansong Zhou Baohua Li Chanjuan Peng Fenfen Wang Zhiqin Fu Caiyun Zhou Die Hong Feng Ye Weiguo Lü Xing Xie | 2013 | Antiviral Research2013，，2： | 2 |
| 3 | Advent of genomics in blueberry显示文摘 | Die J V Rowland L J | 2013 | Mol Breed-ing2013，32，： | 1 |
| 4 | Sitting comfort and discomfort and the relationships with objective measures显示文摘 | De Looze M P De Kuijt-Evers L F M Van Dieёn J | 2003 | Ergonomics2003，46，10： | 1 |
| 5 | Marek's disease virus(MDV) encodes an interleukin-8 homolog(vIL-8):characterization of the vIL-8 protein and a vIL-8 deletion mutant MDV显示文摘 | PARCELLS M S LIN S F DIE NGLEWICZ R L | 2001 | J Virol2001，75，11： | 1 |
| 6 | Sitting comfort and discomfort and the relationships with objective measures显示文摘 | De Looze M P Kuijt-Evers L F M Van die?nJ | 2003 | Ergonomics2003，46，98： | 1 |
| 7 | Sitting Comfort and Discomfort and the Relationships with Objective Measures 显示文摘 | De Looze M P De Kuijt - Evers L F M Van Die en J | 2003 | Ergonomics2003，46，10： | 1 |
| 8 | Analysis if biocide transport limitation in an artificial biofilm显示文摘 | Stewart PS Grab L Die met J A | 1998 | J Appl Microbiol1998，85，： | 1 |
| 9 | Clinical acceptance and ac- curacy assessment of spinal implants guided with SpineAssist surgical robot retrospective study显示文摘 | Devito DP Kaplan L Died R | 2010 | Spine (Phila Pa1976)2010，35，24： | 1 |
| 10 | Carbon nanotubes supported PtPd hollow nanospheres for formic acid electrooxidation显示文摘 | Liu B Li H Y Die L | 2009 | Journal of Power Sources2009，186，1： | 1 |
| 11 | Coma in an alcoholic:Marchiafava- Bignami disease显示文摘 | Haas L Tjan D Die JV | 2006 | J New Zealand Medii~a''l:'A''ssociat~on2006，119，1244： | 1 |
| 12 | PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling显示文摘Oral squamous cell carcinoma(OSCC)has a high incidence of metastasis.Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary;however,only a few patients with OSCC respond to this treatment.Therefore,it is essential to gain insights into the molecular mechanisms underlying the growth and metastasis of OSCC.In this study,we analysed the expression levels of protein kinase D3(PKD3)and PD-L1 and their correlation with the expression of mesenchymal and epithelial markers.We found that the expression of PKD3 and PD-L1 in OSCC cells and tissues was significantly increased,which correlated positively with that of mesenchymal markers but negatively with that of epithelial markers.Silencing PKD3 significantly inhibited the growth,metastasis and invasion of OSCC cells,while its overexpression promoted these processes.Our further analyses revealed that there was positive feedback regulation between PKD3 and PD-L1,which could drive EMT of OSCC cells via the ERK/STAT1/3 pathway,thereby promoting tumour growth and metastasis.Furthermore,silencing PKD3 significantly inhibited the expression of PD-L1,and lymph node metastasis of OSCC was investigated with a mouse footpad xenograft model.Thus,our findings provide a theoretical basis for targeting PKD3 as an alternative method to block EMT for regulating PD-L1 expression and inhibiting OSCC growth and metastasis. | Bomiao Cui Jiao Chen Min Luo Yiying Liu Hongli Chen Die Lü Liwei Wang Yingzhu Kang Yun Feng Libin Huang Ping Zhang | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 13 | Sit-ting Comfort and Discomfort and the Relationships withObjective Measures显示文摘 | De Looze M P Kuijt-Evers L F Van Die?n J | 2003 | Ergonomics2003，46，98： | 1 |
| 14 | Coma in an alcoholic:Marchiafava-Bignami disease显示文摘 | Haas L Tjan D Die JV | 2006 | J New Zealand Med Associ2006，119，： | 1 |
| 15 | The second problem of probabilistic regression显示文摘 | GRAFAREND DIE W AWANGE D I J L | 2012 | Linear &-Nonlinear Models2012，25，6： | 1 |
| 16 | An evaluation of management strategies for Atlantic tuna stocks 显示文摘 | Kell L T Die D J Restrepo V R | 2003 | Scientia Marina2003，67，1： | 1 |
| 17 | Impaired capacity for upregulation of MHC class I] ex- pression in tttmor-associated microglia 显示文摘 | Schartner J Hagar AR Van Handel M Zhang L Nadkarni N Ba- die B | 2005 | Glia2005，51，4： | 1 |
| 18 | Sitting comfort and discomfort and the relationships with objective measures 显示文摘 | de LOOZE M P de KUIJT-EVERS L F M van DIE EN J | 2003 | Ergonomics2003，46，10： | 1 |
| 19 | Sitting comfort and discomfort and the relationships with objective measures显示文摘 | de Looze M P de Kuijt-Evers L F M van Die en J | 2003 | Ergonomics2003，46，10： | 1 |
| 20 | Sitting Comfort and Discomfort and the Relationships with Objective Measures显示文摘 | De Looze M P De Kuijt-Evers L F M Van Die en J | 2003 | Ergonomics2003，46，10： | 1 |
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