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| 1 | The growth mechanism of the basic magnesium chloride whisker显示文摘Based on the theoretical model of anion coordination polyhedron growth units, the growth mechanism of the basic magnesium chloride whisker was discussed in this paper.It was found that the basic magnesium chloride whisker habits were related to the different environments in which anion coordination polyhedra grew. The growth units of basic magnesium chloride whiskers are [Mg - (OH) 4]2 -and [Mg - Cl 4]2 -. The growth process is the incorporation process of growth units. Growth units will have different incorporations and orientations caused by different system characters or heating. Furthermore, the formation mechanism of basic magnesium chloride whiskers was also interpreted using anion coordination polyhedron growth units. | WU JianSong XIAO YingKai SU JingYun DENG TingTing FENG JieRong MO YuYing ZENG Mei | 2011 | Science China(Technological Sciences)2011，54，3： | 18 |
| 2 | The growth mechanism of hydrotalcite crystal显示文摘From the point of growth units, the growth mechanism of hydrotalcite (HT) crystal is investigated in this paper. Results show that the growth morphology of HT is consistent with the model of anion coordination polyhedron growth units. The Raman shift of growth solutions of HT, Cu-HTlc, and Cu-Zn-HTlc are monitored using Raman spectroscopy. In the experiment, the growth units of Mg-Al-hydrotalcite are [Mg-(OH)6]4- and [Al-(OH)6]3-, and the growth units of Cu-Htlc and Cu-Zn-HTlc are [Mg-(OH)6]4- and [Al-(OH)6]3-, respectively. The growth process of hydrotalcite is as follows: growth units first incorpo- rate into metal layers, then metal layers adsorb An- and H2O, and the growth units incorporate into layer compounds according to this rule. Growth units will have different incorporations and growth morphologies caused by different growth surroundings. Furthermore, the reason why Cu-HTlc is difficult to synthesize is also interpreted in this paper. | WU JianSong XIAO YingKai WAN JianYu WEN LiRong | 2012 | Science China(Technological Sciences)2012，55，4： | 15 |
| 3 | A study protocol of population-based cancer screening cohort study on esophageal,stomach and liver cancer in rural China显示文摘Objective:National Health Commission of the People's Republic of China collaborated with many ministries and commissions government and initiated a population-based cancer screening program in high-risk area of rural China,targeting three types of cancer that are most prevalent in these areas,including esophageal,stomach and liver cancer.This study protocol was reported to show the design and evaluate the effectiveness of cancer screening and appropriate screening strategies of three cancers in rural China.Methods and analysis:A two-step design with cancer risk assessment based on questionnaire interview,Hepatitis B surface antigen(HBsAg)test strip and subsequent clinical intervention for high-risk populations was adopted&ee of charge at the local hospitals designated in the program.Ethic and dissemination:This study was approved by the Institutional Review Board of Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College.The results will evaluate the effectiveness of cancer screening and appropriate screening strategies in rural China. | Jiang Li He Li Hongmei Zeng Rongshou Zheng Maomao Cao Dianqin Sun Jiansong Ren Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 10 |
| 4 | A comparative study on polypropylene separators coated with different inorganic materials for lithium-ion batteries显示文摘 | Linghui Yu Jiansong Miao Yi Jin Jerry Y.S. Lin | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 9 |
| 5 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 6 | 8-Bromo-7-methoxychrysin-blocked STAT3/ Twist axis inhibits the sternness of cancer stem cell-like cell originated from SMMC-7721 cells显示文摘抄写 3 的信号变换器和使活跃之物(STAT3 ) 是能调整房间增长,幸存,和开发的潜伏的细胞质的 transcriptional 因素的家庭的一个成员。扭曲是 STAT3 的目标基因,这被报导了,并且发信号的 STAT3/Twist 在调整癌症进步起一个重要作用。这里,探索 8-bromo-7-methoxychrysin (BrMC ) 是否禁止肝癌症经由破坏 STAT3/Twist 发信号的像茎的房间(LCSLC ) 性质,我们在 vitro 的有教养的 SMMC-7721 房间,并且由决定形成范围的能力和迁居在球状体的 stemness 上评估了 BrMC 的效果。范围形成试金结果在 LCSLC 显示出形成范围的能力的集中依赖者减少(P < 0.05 ) 与 BrMC 的不同集中对待。愈合创伤的试金结果在与 BrMC 的不同集中对待的 LCSLC 的房间移植表明了集中依赖者衰落。另外, CD133, CD44,和 ALDH1 层次在与 BrMC 对待的 LCSLC 被减少。有 BrMC 的不同集中的治疗也减少了 p-STAT3 和 Twist1 蛋白质的表情。BrMC 的效果被合作处理实质地与 JSI-124 提高, STAT3 的一个特定的禁止者。Twist1 的宫外的表示在 LCSLC 在标记的范围形成,移植,和表示上稀释了 BrMC 的禁止的效果。然而,它不有在 LCSLC 在 p-STAT3 上影响表示。这些结果证明 BrMC 禁止 LCSLC 的 stemness 由禁止 STAT3/Twist 从 SMMC-7721 房间线发源信号轴。 | Yimin Luo Yinghong Cui Xiaocheng Cao Xiang Li A Chen Jiansong Zhang Xiangding Chen Jianguo Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 7 |
| 7 | Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030显示文摘Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the future.However,little is known about the economic burden of lung cancer in China.Methods:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary surveys.Other parameters were obtained from literatures and official reports.Projections were conducted based on varying parameters.All expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,respectively.The estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature death.Under current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,respectively.However,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's GDP.Conclusions:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the future.Policy makers need to take urgent actions in budget making for health systems.The economic burden could be alleviated by reducing the disease burden of lung cancer via effective control and prevention actions. | Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai | 2021 | Chinese Journal of Cancer Research2021，33，1： | 6 |
| 8 | Throughput Maximization for Multi-UAV Enabled Millimeter Wave WPCN: Joint Time and Power Allocation显示文摘In this paper,we investigate the effective deployment of millimeter wave(mmWave)in unmanned aerial vehicle(UAV)-enabled wireless powered communication network(WPCN).In particular,a novel framework for optimizing the performance of such UAV-enabled WPCN in terms of system throughput is proposed.In the considered model,multiple UAVs monitor in the air along the scheduled flight trajectory and transmit monitoring data to micro base stations(mBSs)with the harvested energy via mmWave.In this case,we propose an algorithm for jointly optimizing transmit power and energy transfer time.To solve the non-convex optimization problem with tightly coupled variables,we decouple the problem into more tractable subproblems.By leveraging successive convex approximation(SCA)and block coordinate descent techniques,the optimal solution is obtained by designing a two-stage joint iteration optimization algorithm.Simulation results show that the proposed algorithm with joint transmit power and energy transfer time optimization achieves significant performance gains over Q-learning method and other benchmark schemes. | Jiansong Miao Pengjie Wang Qian Zhang Yue Wang | 2020 | China Communications2020，17，10： | 6 |
| 9 | Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation显示文摘象 bystin 一样(BYSL ) 基因以前被描绘为参予早胚胎培植的房间粘附编码附件蛋白质。它也涉及 40S ribosomal 子单元生物的续生说并且被发现在很快种胚胎和癌症房间线被表示。以便在癌症房间增长和生长探索 BYSL 的角色,我们把 hepatocellular 癌(HCC ) 用作一个模型。这里,我们报导 BYSL 在 vitro 并且在 vivo 为 HCC 房间生长是关键的。在人的 HCC 标本的 BYSL mRNA 和蛋白质的表示层次显著地与在邻近的非癌的织物看见的那些相比被增加。在 vitro,由短发卡 RNA 的 BYSL 的抑制减少了 HCC 房间增长,导致了 apoptosis 并且部分在 G2/M 阶段逮捕了房间周期。在 vivo,与 BYSL siRNA 对待的 HCC 房间没能在下的培植以后在裸体老鼠形成肿瘤。为了为 BYSL 导致 RNAi 的细胞生长决定细胞的基础,逮捕, BYSL subcellular 本地化在有丝分裂并且分裂期间 HepG2 细胞被检验。BYSL 在 nucleologenesis 期间在多重阶段是在场的,在导出核的 foci (NDF ) 包括, perichromosomal 区域和 prenucleolar 身体(PNB ) 在有丝分裂期间。BYSL 弄空显著地压制了 NDF 和 PNB 形成,并且在有丝分裂以后破坏了 nucleoli 汇编,导致增加的 apoptosis 和到浆液饥饿的 HCC 房间的减少的忍耐。一起拿,我们的研究显示那 upregulated BYSL 表情在 hepatocarcinogenesis 起一个作用。 | Hanzhi Wang Wei Xiao Qinbo Zhou Yun Chen Shuo Yang Jiansong Sheng Yanqing Yin Jia Fan Jiawei Zhou | 2009 | Cell Research2009，19，10： | 5 |
| 10 | Inhibition of acetylcholinesterase by two genistein derivatives:kinetic analysis,molecular docking and molecular dynamics simulation显示文摘In this study two genistein derivatives(G1 and G2)are reported as inhibitors of acetylcholinesterase(AChE)and butyrylcholinesterase(BuChE),and differences in the inhibition of AChE are described.Although they differ in structure by a single methyl group,the inhibitory effect of G1(IC50¼264 nmol/L)on AChE was 80 times stronger than that of G2(IC50¼21,210 nmol/L).Enzyme-kinetic analysis,molecular docking and molecular dynamics(MD)simulations were conducted to better understand the molecular basis for this difference.The results obtained by kinetic analysis demonstrated that G1 can interact with both the catalytic active site and peripheral anionic site of AChE.The predicted binding free energies of two complexes calculated by the molecular mechanics/generalized born surface area(MM/GBSA)method were consistent with the experimental data.The analysis of the individual energy terms suggested that a difference between the net electrostatic contributions(ΔEele+ΔGGB)was responsible for the binding affinities of these two inhibitors.Additionally,analysis of the molecular mechanics and MM/GBSA free energy decomposition revealed that the difference between G1 and G2 originated from interactions with Tyr124,Glu292,Val294 and Phe338 of AChE.In conclusion,the results reveal significant differences at the molecular level in the mechanism of inhibition of AChE by these structurally related compounds. | Jiansong Fang Ping Wu Ranyao Yang Li Gao Chao Li Dongmei Wang Song Wu Ai-Lin Liu Guan-Hua Du | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 5 |
| 11 | Classifying risk level of gastric cancer: Evaluation of questionnaire-based prediction model显示文摘Objective: This study aimed at evaluating the efficacy of the questionnaire-based prediction model in an independent prospective cohort.Methods: A cluster-randomized controlled trial was conducted in Changsha, Harbin, Luoshan, and Sheyang in eastern China in 2015-2017. A total of 182 villages/communities were regarded as clusters, and allocated to screening arm or control arm randomly. Face-to-face interview through a questionnaire interview, including of relevant risk factors of gastric cancer, was administered for each subject. Participants were further classified into high-risk or low-risk groups based on their exposure to risk factors. All participants were followed up until December 31, 2019. Cumulative incidence rates from gastric cancer between high-risk and low-risk groups were calculated and compared using the log-rank test. Cox proportional hazard regression models were applied to estimate hazard ratio(HR) and 95% confidence interval(95% CI).Results: Totally, 89,914 residents were recruited with a mean follow-up of 3.47 years. And 42,015(46.73%)individuals were classified into high-risk group and 47,899(53.27%) subjects were categorized into low-risk group.Gastric cancer was diagnosed in 131 participants, of which 91 were in high-risk group. Compared with the low-risk participants, high-risk individuals were more likely to develop gastric cancer(adjusted HR=2.15, 95% CI,1.23-3.76). The sensitivity of the questionnaire-based model was estimated at 61.82%(95% CI, 47.71-74.28) in a general population.Conclusions: Our questionnaire-based model is effective at identifying high-risk individuals for gastric cancer. | Maomao Cao He Li Dianqin Sun Lin Lei Jiansong Ren Jufang Shi Ni Li Ji Peng Wanqing Chen | 2020 | Chinese Journal of Cancer Research2020，32，5： | 5 |
| 12 | MicroRNA-182 promotes pancreatic cancer cell proliferation and migration by targeting β-TrCP2显示文摘胰腺的癌症是好攻击的恶意。中部的幸存率仍然保持低,显示新奇 biomarkers 和治疗学的目标的鉴定是批评的。这里,我们在胰腺的癌症开发检验了 microRNA-182 (miR-182 ) 的角色。人的胰腺的癌症标本和房间线的分析证明 miR-182 是在胰腺的癌症的 overexpressed 并且支持肿瘤增长和侵略。-TrCP2 作为 miR-182 的一个直接目标被证实。-TrCP2 的 Silencing 增加了类似于 miR-182 overexpression 的 -catenin, 的层次。-TrCP2 的宫外的表示禁止了 -catenin 发信号的 miR-182-induced 激活。由 -TrCP2 的 miR-182 和它的颠倒的 oncogenic 效果在 vivo 被证实。这研究建议 -TrCP 和 miR-182 可以为胰腺的癌症的早察觉和治疗是可能的 biomarkers 和目标。 | Shi Wang Jiansong Ji Jingjing Song Xue Li Shilong Han Weishuai Lian Chuanwu Cao Xiaoping Zhang Maoquan Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 4 |
| 13 | Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer显示文摘diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer.Herein,we aimed to develop a novel mesoporous polydopamine(MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging(MRI)-guided cancer chemo-photothermal therapy.Superparamagnetic iron oxide(SPIO)-loaded MPDA NPs(MPDA@SPIO)was firstly prepared,followed by modifying with a targeted molecule of sialic acid(SA)and chelating with Fe^(3+)(SA-MPDA@SPIO/Fe^(3+) NPs).After that,doxorubicin(DOX)-loaded SA-MPDA@SPIO/Fe^(3+) NPs(SA-MPDA@SPIO/DOX/Fe^(3+))was prepared for tumor theranostics.The prepared SAPEG-MPDA@SPIO/Fe^(3+) NPs were water-dispersible and biocompatible as evidenced by MTT assay.In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability,with relaxivity of being r1=4.29 mM��1s��1 and r2=105.53 mM��1s��1,respectively.SAPEG-MPDA@SPIO/Fe^(3+) NPs could effectively encapsulate the DOX,showing dual pH-and thermal-triggered drug release behavior.In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe^(3+) NPs could effectively target to the hepatic tumor tissue,which was possibly due to the specific interaction between SA and the overexpressed E-selectin.This behavior also endowed SA-MPDA@SPIO/DOX/Fe^(3+)NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification.In addition,SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs displayed a superior therapeutic effect,which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy.These results demonstrated that SAPEG-MPDA@SPIO/DOX/Fe^(3+) NPs is an effective targeted nanoplatform for tumor theranostics,having potential value in the effective treatment of hepatic cancer. | Gaofeng Shu Minjiang Chen Jingjing Song Xiaoling Xu Chenying Lu Yuyin Du Min Xu Zhongwei Zhao Minxia Zhu Kai Fan Xiaoxi Fan Shiji Fang Bufu Tang Yiyang Dai Yongzhong Du Jiansong Ji | 2021 | Bioactive Materials2021，6，5： | 4 |
| 14 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 15 | (N,F)-codoped TiO_2 Nanocrystals as Visible Light-activated Photocatalyst显示文摘(N, F)-codoped anatase TiO2 nanocrystals with active visible light response were prepared by using a simple sol-gel approach. X-ray photoelectron spectroscopy measurements suggested that the substitutional N and F species replaced the lattice oxygen atoms in TiO2 nanocrystals. Such nanocrystals showed strong absorption from 400 to 550 nm, which was mainly induced by nitrogen doping. The phase transformation from anatase to rutile was hindered by fluorine doping at high calcination temperatures, which was verified by XRD patterns. The N2 adsorption-desorption isotherms revealed the absence of mesopores in these nanocrystals. The (N, F)-codoped TiO2 nanocrystals showed satisfying photocatalytic activity on the photo-degradation of methylene blue under visible light. | Yanling Meng Jiansong Chen Ying Wang Hanming Ding Yongkui Shan | 2009 | Journal of Materials Science & Technology2009，25，1： | 3 |
| 16 | Improved esophageal squamous cell carcinoma screening effectiveness by risk-stratified endoscopic screening:evidence from high-risk areas in China显示文摘Background:Risk-stratified endoscopic screening(RSES),which offers endoscopy to those with a high risk of esophageal cancer,has the potential to increase effectiveness and reduce endoscopic demands compared with the universal screening strategy(i.e.,endoscopic screening for all targets without risk prediction).Evidence of RSES in high-risk areas of China is limited.This study aimed to estimate whether RSES based on a 22-score esophageal squamous cell carcinoma(ESCC)risk prediction model could optimize the universal endoscopic screening strategy for ESCC screening in high-risk areas of China.Methods:Eight epidemiological variables in the ESCC risk prediction model were collected retrospectively from 26,618 individuals aged 40-69 from three high-risk areas of China who underwent endoscopic screening betweenMay 2015 and July 2017.The model’s performance was estimated using the area under the curve(AUC).Participants were categorized into a high-risk group and a low-risk group with a cutoff score having sensitivities of both ESCC and severe dysplasia and above(SDA)at more than 90.0%.Results:The ESCC risk prediction model had an AUC of 0.80(95% confidence interval:0.75-0.84)in this external population.We found that a score of 8(ranging from 0 to 22)had a sensitivity of 94.2% for ESCC and 92.5% for SDA.The RSES strategy using this threshold score would allow 50.6% of endoscopies to be avoided and save approximately US$0.59 million compared to universal endoscopic screening among 26,618 participants.In addition,a higher prevalence of SDA(1.7%vs.0.9%),a lower number need to screen(60 vs.111),and a lower average cost per detected SDA(US$3.22 thousand vs.US$5.45 thousand)could have been obtained by the RSES strategy.Conclusions:The RSES strategy based on individual risk has the potential to optimize the universal endoscopic screening strategy in ESCC high-risk areas of China. | He Li Chao Ding Hongmei Zeng Rongshou Zheng Maomao Cao Jiansong Ren Jufang Shi Dianqin Sun Siyi He Zhixun Yang Yiwen Yu Zhe Zhang Xibin Sun Guizhou Guo Guohui Song Wenqiang Wei Wanqing Chen Jie He | 2021 | Cancer Communications2021，41，8： | 3 |
| 17 | Expression of CD44v6 gene in normal human peripheral blood显示文摘AIM: To investigate if CD44v6 could be used as a molecular marker of cancer progression and metastasis through the detection of CD44v6 gene expression in normal human peripheral blood.METHODS: RNA was extracted from the peripheral blood mononuclear cells of 50 healthy donors, the expression of CD44v6 was investigated using reverse transcriptasepolymerase chain reaction (RT-PCR).RESULTS: CD44v6 mRNA was detected in 58% of healthy volunteers under the proper controls.CONCLUSION: Our results suggest that the measurement of CD44v6 expression in peripheral blood by RT-PCR is not suitable for detection of circulating tumor cells. | JianSong Dong-ShengZhang JieZheng | 2005 | World Journal of Gastroenterology2005，11，23： | 3 |
| 18 | Fibrosis of corpus cavernosum in animals following cavernous nerve ablation显示文摘t Aim: To investigate alterations of smooth muscle cells and collagen fibers in corpus cavernosum following cavernous neurectomy and its relation to the expression of transforming growth factor-β1 (TGF-β1). Methods: Ten adult male SD rats (neurectomy group) were subject to a bilateral cavernous nerve (CN) resection aseptically under an operating microscope, with 6 sham-operated rats as the control. Fifteen weeks after the operation, the penile specimens were collected and prepared for quantitative-analyzing of ratio of smooth muscle to collagen fibers in corpus cavernosum with confocal microscopy, and for detecting the expression of TGF-β1 by RT-PCR and westernblot.Results: Smooth muscle cells that show red color after fluorescent-labeling with tetramethylrhodamine isothiocyanatephalloidin and collagen fibers that produce green autofluorescence after paraformaldehyde fixation were clearly identified under the confocal microscope. Quantification of fluorescent intensity showed that the ratio of smooth muscle to collagen fibers in corpus cavernosum in neurectomy group was 0.265± 0.125, which was significantly lower than that in sham-operated group (0.760±0.196, P<0.01). RT-PCR and western-blot analyses revealed a significantlyhigher expression of TGF-β1 in the penile tissues of the neurectomy animals than that in sham-operated group.Conclusion: Bilateral ablation of CN can lead to fibrosis of corpus cavernosum, which may be related to an increased expression of TGF-β1 induced by hypoxia in cavernous tissue after denervation. | Wan-LiHu Li-QuanHu jianSong Shi-WenLi Xin-MinZheng BeiCheng Bing-ChunTian | 2004 | Asian Journal of Andrology2004，6，2： | 3 |
| 19 | Single-step flash-heat synthesis of red phosphorus/ graphene flame-retardant composite as flexible anodes for sodium-ion batteries显示文摘红磷(RP ) 为高效的 Na 离子电池作为阳极吸引了可观的注意,由于它的低费用和 2,600 mAh/g 的高理论特定的能力。在这研究,一个灵巧的单个步的闪光热处理被开发完成 graphene 氧化物的减小(去) 并且 RP 的同时的免职到减少的 graphene 氧化物(rGO ) 上表。产生 RP/rGO 合成被显示是克服在骑车期间与差的电子传导性和 RP 的大体积变化联系的期的一个有希望的候选人。RP/rGO 灵活电影阳极在 1 A/g 的控告 / 解除电流密度在 200 个周期期间交付了 1,625 mAh/g 的一个平均能力。在 1, 2, 4,和 6 A/g 当前的密度的 1,786, 1,597, 1,324,和 679 mAh/g 的平均电荷能力在率能力测试被获得。而且由于 RP 部件, RP/rGO 电影与一部 rGO 电影相比介绍了优异火焰 retardancy。这个工作因此介绍一个高度可存取的合成方法向 Na 离子存储与优异电气化学的性能准备灵活、安全的 RP 阳极。 | Yihang Liu Anyi Zhang Chenfei Shen Qingzhou Liu Jiansong Cai Xuan Cao Chongwu Zhou | 2018 | Nano Research2018，11，7： | 3 |
| 20 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
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