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| 1 | The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients显示文摘 | Yefei Huang Weimin Wang Yansu Chen Yulin Huang Jianbing Zhang Song He Yongfei Tan Fulin Qiang Aiping Li Oluf Dimitri R?e Shouyu Wang Yan Zhou Jianwei Zhou | 2014 | Journal of Gastroenterology2014，，11： | 2 |
| 2 | Aeolian dust dynamics in the Fergana Valley, Central Asia, since -30 ka inferred from loess deposits显示文摘Knowledge of the interactions among atmospheric dynamics,dust emissions and climate system is essential to understand the physical mechanisms for the dust lifecycle,their role in loess formation as well as the predictions of future dust concentration.However,these issues still remain relatively poorly known in Central Asia(CA).The extensive loess deposits on the CA pediments provide a promising archive to explore atmospheric dust dynamics and climatic conditions in the past and their association with loess formation.This study investigates the granulometric and magnetic properties of a loess section(named Osh section)in the Fergana Valley,which provides a sensitive record of atmospheric dust dynamics since 30 ka based on radiometric(AMS ^(14)C)dating.The frequency-dependent magnetic susceptibility(χfd)and the mean grain size are used to reconstruct the broadscale effective moisture and summer atmospheric dynamics pattern in CA,respectively.The results show that the precession forcing exerts a huge influence on the wind-regime variabilities in CA,but with different physical processes under the impact of the Northern Hemisphere ice sheet(NHIS)before and after 15 ka.The origin of the sedimentation rate variations in the Osh loess is also linked to the NHIS-modulated changes of the atmospheric circulation patterns.Either the strengthened westerlies or the increased surface roughness from higher vegetation cover in loess-deposition areas have significantly accelerated the loess accumulation.As a result,these complicated influence factors of sedimentation rate change in the Osh loess section,especially during the Holocene epoch,may hamper accessibility of the authentic dust emission flux and atmospheric dust concentration in CA. | Yue Li Yougui Song Dimitris G.Kaskaoutis Jinbo Zan Rustam Orozbaev Liangcheng Tan Xiuling Chen | 2021 | Geoscience Frontiers2021，12，5： | 1 |
| 3 | Multiple-Precision Fixed-Point Vector Multiply-Accumulator using Shared Segmentation显示文摘 | Albert Danysh Michael Liebelt | 2002 | IEEE Transactions on Electronic Computers2002，17，3： | 1 |
| 4 | MDM 2 is a useful prognostic biomarker for resectable gastric cancer显示文摘 | Yang Ye Xuan Li Jingjing Yang Shuhan Miao Shouyu Wang Yansu Chen Xiaowei Xia Xuming Wu Jianbing Zhang Yan Zhou Song He Yongfei Tan Fulin Qiang Gang Li Oluf Dimitri R?e Jianwei Zhou | 2013 | Cancer Sci2013，，5： | 1 |
| 5 | Architecture and imple-mentation of a vector/SIMD multiply-accumulate unit 显示文摘 | Albert Danysh Dimitri Tan | 2005 | IEEE Transactions on Computers2005，54，3： | 1 |
| 6 | Molecular recognition of live methicillin-resistant staphylococcus aureus cells using DNA aptamers显示文摘AIM: To generate DNA-aptamers binding to Methicillinresistant Staphylococcus aureus(MRSA).METHODS: The Cell-Systematic Evolution of Ligands by Exponential Enrichment(SELEX) technology was used to run the selection against MRSA bacteria and develop target-specific aptamers. MRSA bacteria were targeted while Enterococcus faecalis bacteria were used for counter selection during that process. Binding assays to determine the right aptamer candidates as well as binding assays on clinical samples were performed through flow cytometry and analyzed using the FlowJ o software. The characterization of the aptamers was done by determination of their Kd values and determined by analysis of flow data at different aptamer concentration using Sigma Plot. Finally, the recognitionof the complex Gold-nanoparticle-aptamer to the bacteria cells was observed using transmission electron microscopy(TEM).RESULTS: During the cell-SELEX selection process, 17 rounds were necessary to generate enrichment of the pool. While the selection was run using fixed cells, it was shown that the binding of the pools with live cells was giving similar results. After sequencing and analysis of the two last pools, four sequences were identified to be aptamer candidates. The characterization of those aptamers showed that based on their Kd values, DTMRSA4 presented the best binding with a Kd value of 94.61 ± 18.82 nmol/L. A total of ten clinical samples of MRSA, S. aureus and Enterococcus faecalis were obtained to test those aptamers and determine their binding on a panel of samples. DTMRSA1 and DTMRSA3 showed the best results regarding their specificity to MRSA, DTMRSA1 being the most specific of all. Finally, those aptamers were coupled with gold-nanoparticle and their binding to MRSA cells was visualized through TEM showing that adduction of nanoparticles on the aptamers did not change their binding property.CONCLUSION: A total of four aptamers that bind to MRSA were obtained with Kd values ranking from 94 to 200 nmol/L. | Diane Turek Dimitri Van Simaeys Judith Johnson Ismail Ocsoy Weihong Tan | 2013 | World Journal of Translational Medicine2013，2，3： | 0 |
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