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8篇 您的检索式:作者名="Dimitris N B"
    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2Robust optimization with simulated an- nealing显示文摘Dimitris B Omid N 2010Journal of Global Optimization2010,48,2:1
3Restless Bandits, Linear Programming Relaxations, and a Primal-Dual Index Heuristic显示文摘DIMITRIS B JOSE N JOSE N 2010Operation Research2010,48,1:1
4Treatment of multiple adjacent Miller class I and II gingival recessions with a Modified Coronally Advanced Tunnel ( MCAT ) technique and a collagen matrix or palatal connective tissue graft: a randomized, controlled clinical trial显示文摘Sofia Aroca Bálint Molnár Péter Windisch István Gera Giovanni E. Salvi Dimitris Nikolidakis Anton Sculean 2013J Clin Periodontol2013,,7:1
5Crystallization kinetics and nucleation activity of filler in polypropylene/surface-treated SiO2 nanocomposites 显示文摘George Z P Dimitris S A Dimitris N B 2005Thermochimica Acta2005,427,1:1
6Robust design simu- lation:a probabilistic approach to multidisciplinary design 显示文摘Dimitri N M Oliver B Daniel A D 1999Journal of Aircraft1999,36,1:1
7Multiple time resolution unit commitment for short-term operations scheduling under high renewable penetration 显示文摘EMMANOUIL A B PANDELIS N B DIMITRIS P L l 20141EEE Transactions on Power Systems2014,29,1:1
8Crystallization and melting behavior of three biodegradable poly(alkylene succinates)显示文摘George Z P Dimitris N B 2005A comparative study Polymer2005,,12:1
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