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| 1 | Elevation of tumor necrosis factor-α,interleukin-1β and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes显示文摘有调停毒素的胰腺的损坏的背景大动物模型关于糖尿病 mellitus 和心血管的糖尿病的复杂并发症在研究广泛地被使用了。试图证实有 streptozotocin ( STZ )的中国贵州 minipig 模型导致了糖尿病并且描绘动物的现在的学习由在大动脉的墙中分析煽动性的 cytokine 层次当模特儿,例如肿瘤坏死因素( TNF ), interleukin-1 ( IL-1 )和 interleukin-6 ( IL-6 ) .Methods 22 男中国贵州 minipigs (变老, 4~6 个月;重量, 20 kg 到 30 kg ) 被划分成导致 STZ 的糖尿病的组(n=12 ) 和控制组(n=10 ) 。STZ (125 mg/kg ) 被管理导致多糖症,以后,胰岛素被用来在 10 mmol/L 下面控制 fasting 血葡萄糖层次。口头的葡萄糖忍耐测试(OGTT ) 以前被执行并且在 STZ 管理和丙氨酸 transaminase,天门冬素 transaminase,白朊,血脲氮, creatinine,类脂化合物和白色的浆液集中以后的一个月血房间计数以前并且六个月以后被测量。在六个月和胰为小岛房间 immunohistochemically 被检验以后,在两个组的动物是 euthanized。糖尿病的 minipigs 和控制的大动脉的 intima 在由西方的污点中等的调节的组织为 TNF- 水平被分析。在大动脉的 intima 的 TNF- , IL-1 和 IL-6 mRNA 层次是由反向的抄写和聚合酶链反应(RT-PCR ).Results 的 assayed 在浆液葡萄糖层次的重要举起被观察在 STZ 正式就职(P0.001 ) 和显著地增加的 OGTT 价值以后的一个月和六个月被注意,与基线数据相比。正常的胰有许多不规则的大小的小岛和小岛房间的小簇,当在糖尿病的 minipigs 的胰小岛房间几乎消失了时。没有统计差别以前在生物化学的考试的浆液集中被通知并且在 STZ 以后的六个月感应。西方的污点证明在 aotic intima 的戏剧性地增加的TNF-水平调节了TNF-, IL-1 和 IL-6 的中等、重要的举起 mRNA 层次被现在的学习建立了的 RT-PCR.Conclusions 揭示有 导致STZ 的 diabetes.Inflammatory cytokines 的中国贵州 minipig 模型(TNF-, IL-1 和 IL-6 )显著地在糖尿病的 minipigs 的大动脉的 intima 提高了。 | LU Lin ZHANG Qi PU Li-jin XU Xue-wei ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zheng-kun LU An-kang DING Feng-hua SHEN Jie CHEN Qiu-jin LOU Sheng FANG Dan-hong SHEN Wei-feng | 2007 | Chinese Medical Journal2007，，6： | 43 |
| 2 | Immunoregulatory Effects of Ethyl-acetate Fraction of Extracts from Tetrastigma Hemsleyanum Diels et. Gilg on Immune Functions of ICR Mice显示文摘Objective To evaluate the effects of ethyl-acetate fraction (EAF) of extracts from Tetrastigma hemsleyanum Diels et. Gilg (TDG) on immune functions of ICR mice. Methods ICR mice were exposed to different doses of EAF for 15 or 30 days and then their immune functions were analyzed, including ConA-induced splenic lymphocyte transformation, SRBC- induced delayed type hypersensitivity response, serum hemolysin analysis, antibody-producing cells, peritoneal macrophage phagocytized chicken red blood cells, natural killer cell activity, and serum level of cytokines. Results EAF of extracts from TDG at different doses had various effects on immune functions of ICR mice. As compared with the controls, it increased the mouse spleen lymphocyte transformation induced by ConA, the left-hind voix pedis thickness and the number of plague forming cells (PFCs) at the dose of 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the ink clearance ability at the dose of 0.91 mg/mL, 1.82 mg/mL, 5.48 mg/mL, and 9.12 mg/mL, respectively; increased the phagocytosis index of mononuclear-macrophages and production of serum interferon-gamma (IFN-γ) at the dose of 5.48 mg/mL; and could promote the production of serum tumor necrosis factor-alpha (TNF-α) at the dose of 9.12 mg/mL. Conclusion EAF of extracts from TDG can regulate mouse immune functions in vivo. | CAI-JU XU GANG-QIANG DING JIAN-YUN FU JIA MENG RONG-HUA ZHANG XIAO-MING LOU | 2008 | Biomedical and Environmental Sciences2008，21，4： | 49 |
| 3 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 4 | Crustal structure of the northwestern sub-basin, South China Sea: Results from a wide-angle seismic experiment显示文摘The crustal structure of the northwestern sub-basin area of the South China Sea was modeled by inverting a wide-angle seismic survey line across the entire region and on both sides of its bounding continental margins. The survey line extended over 484 km. A total of 14 Ocean Bottom Seismometers (OBS) were deployed at intervals of 30 km to record air-gun array sources with a combined volume of 5160 in 3 . The crustal velocity structure of the northwestern sub-basin area was acquired through the integration of multi-channel seismic data. OBS data were processed and modeled initially using ray tracing inversion techniques. Results indicate that crustal thickness under the continental slope decreases from 21 to 11 km, crustal thickness of the northwestern sub-basin is 7.7 km, and the depth to the Moho ascends from 21 km under the upper continental slope to 11 km under the middle basin. The crust of the northwestern sub-basin is similar to that of the eastern sub-basin in its oceanic crustal structure. This structure has a thicker layer 1 (sedimentary layer) and a thinner layer 2. These characteristics are especially clear in the eastern sub-basin, which differs somewhat from typical oceanic crust. The tectonic geometry and velocity structure of the northwestern sub-basin and its margins comprise a symmetrical conjugate and indicate a pure shear mode with regard to the continental margin rifting mechanism. We did not find clear seismic signals from high velocity layers under the lower crust of the continental margin in the northern part of the northwestern sub-basin, which provides new evidence for the idea that the western part of the northern continental margin of the South China Sea constitutes nonvolcanic crust. Because the seafloor spreading period of the northwestern sub-basin was short, layer 2 might have experienced asymmetrical basalt magma flows, which may have blurred the magnetic anomaly lineations of the northwestern sub-basin. | WU ZhenLi LI JiaBiao RUAN AiGuo LOU Hai DING WeiWei NIU XiongWei LI XiBing | 2012 | Science China Earth Sciences2012，55，1： | 19 |
| 5 | ESCRT-I Component VPS23A Affects ABA Signaling by Recognizing ABA Receptors for Endosomal Degradation显示文摘受体在过去的十年在植物科学成为了很重要的进展之一的 PYR/PYL/RCAR-type abscisic 酸(骆驼毛的织物) 的最近的发现。在哺乳动物,排序的 endosomal 充当一条重要小径到 downregulate 受体的不同类型,而是它在植物荷尔蒙发信号的角色糟糕被理解。这里,我们报导那 ubiquitin 象 E2 一样蛋白质, VPS23A,是 ESCRT-I 的一个关键部件,否定地调整骆驼毛的织物发信号。VPS23A 与 PYR/PYL/RCAR-type 骆驼毛的织物受体和提高的 VPS23A 的混乱有 epistatic 关系在在骆驼毛的织物处理下面表明小径的 ABA 的关键 kinase OST1 的活动。而且, VPS23A 与 PYR1/PYLs 交往,连接 K63 的 diubiquitin,和 PYL4 在 vivo 拥有连接 K63 的 ubiquitinated 修正。进一步的分析表明 VPS23A 影响 PYR1 和 PYL4 的稳定性的 subcellular 本地化。一起拿,我们的结果建议 VPS23A 经由调停液泡的降级影响 PYR1/PYL4,提供两个的先进理解在植物荷尔蒙发信号的骆驼毛的织物受体和 ESCRT 的周转。 | Feifei Yu Lijuan Lou Miaomiao Tian Qingliang Li Yanglin Ding Xiaoqiang Cao Yaorong Wu Borja Belda-Palazon Pedro L. Rodriguez Shuhua Yang Qi Xie | 2016 | Molecular Plant2016，9，12： | 17 |
| 6 | Upper mantle anisotropy of the eastern Himalayan syntaxis and surrounding regions from shear wave splitting analysis显示文摘Polarization analysis of teleseismic data has been used to determine the XKS(SKS,SKKS,and PKS)fast polarization directions and delay times between fast and slow shear waves for 59 seismic stations of both temporary and permanent broadband seismograph networks deployed in the eastern Himalayan syntaxis(EHS)and surrounding regions.The analysis employed both the grid searching method of the minimum tangential energy and stacking analysis methods to develop an image of upper mantle anisotropy in the EHS and surrounding regions using the newly obtained shear wave splitting parameters and previously published results.The fast polarization directions are oriented along a NE-SW azimuth in the EHS.However,within the surrounding regions,the fast directions show a clockwise rotation pattern around the EHS from NE-SW,to E-W,to NW-SE,and then to N-S.In the EHS and surrounding regions,the fast directions of seismic anisotropy determined using shear wave splitting analysis correlate with surficial geological features including major sutures and faults and with the surface deformation fields derived from global positioning system(GPS)data.The coincidence between structural features in the crust,surface deformation fields and mantle anisotropy suggests that the deformation in the crust and lithospheric mantle is mechanically coupled.In the EHS,the coherence between the fast directions and the NE direction of the subduction of the Indian Plate beneath the Tibetan Plateau suggests that the lithospheric deformation is caused mainly by subduction.In the regions surrounding the EHS,we speculate that a westward retreat of the Burma slab could contribute to the curved anisotropy pattern.The Tibetan Plateau is acted upon by a NE-trending force due to the subduction of the Indian Plate,and also affected by a westward drag force due to the westward retreat produced by the eastward subduction of the Burma slab.The two forces contribute to a curved lithospheric deformation that results in the alignment of the upper mantle peridotite lattice parallel to the deformation direction,and thus generates a curved pattern of fast directions around the EHS. | CHANG LiJun WANG ChunYong DING ZhiFeng YOU HuiChuan LOU Hai SHAO CuiRu | 2015 | Science China Earth Sciences2015，58，10： | 16 |
| 7 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 8 | Icariin promotes expression of PGC-1α,PPARα,and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro显示文摘Aim:To investigate the effect of icariin on the expression of peroxisome proliferator-activated receptor γ coactivator-1 alpha (PGC-1 α),peroxisome proliferator-activated receptor alpha (PPARα),and nuclear respiratory factor 1 (NRF-1) oncardiomyocyte differentiation of murine embryonic stem (ES) cells in vitro.Methods:The cardiomyocytes derived from murine ES cells were verified byimmunocytochemistry using confocal laser scanning microscopy.Cardiac-specific sarcomeric proteins (ie α-actinin,troponin T) were evaluated when em-bryoid bodies (EB) were treated with icariin or retinoid acid.The expression ofPGC-1α,PPARα,and NRF-1 were analyzed using both semiquantitative RT-PCRand Western blotting in cardiomyocyte differentiation.The phosphorylation ofthe p38 mitogen-activated protein kinase (MAPK) was studied in the differentia-tion process,and its specific inhibitor SB203580 was employed to confirm thefunction of the p38 MAPK on icariin-induced cardiac differentiation.Results:The application of icariin significantly induced the cardiomyocyte differentiationof EB as indicated by the promoted expression of α-actinin and troponin T.Theexpression of PGC-1α,PPARα,and NRF-1 increased coincidently in early differ-entiation and the increase was dose-dependently upregulated by icariin treatment.The phosphorylation of the p38 MAPK peaked on d 6 and decreased after d 8,andthe activation was further enhanced and prolonged when the EB were subjectedto icariin,which was concurrent with the elevation of PGC-1α,PPARα,and NRF-1.Moreover,the inhibition of the p38 MAPK pathway by SB203580 efficientlyabolished icariin-stimulated cardiomyocyte differentiation and resulted in the cap-ture of the upregulation of PGC-1α,PPARα,and NRF-1.Conclusion:Takentogether,icariin promoted the expression of PGC-1α,PPARα,and NRF-1 duringcardiomyocyte differentiation of murine ES cells in vitro and the effect was partlyresponsible for the activation of the p38 MAPK. | Ling DING Xing-guang LIANG Dan-yan ZHU Yi-jia LOU | 2007 | Acta Pharmacologica Sinica2007，28，10： | 15 |
| 9 | Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus: An Observational Cross-sectional Study in Hangzhou, China显示文摘 | Xue Sun Jie He Xiao-Li Ji Yi-Ming Zhao Han-Yu Lou Xiao-Xiao Song Li-Zhen Shan Ying-Xiu Kang Wen-Heng Zeng Xiao-Hong Pang Song-Zhao Zhang Yue Ding Yue-Zhong Ren Peng-Fei Shan | 2017 | Chinese Medical Journal2017，，1： | 14 |
| 10 | Role of gut microbiota via the gut-liver-brain axis in digestive diseases显示文摘The gut-brain axis is a bidirectional information interaction system between the central nervous system(CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut-liver-brain axis. | Jian-Hong Ding Zhe Jin Xiao-Xu Yang Jun Lou Wei-Xi Shan Yan-Xia Hu Qian Du Qiu-Shi Liao Rui Xie Jing-Yu Xu | 2020 | World Journal of Gastroenterology2020，26，40： | 13 |
| 11 | Suppression dampens unpleasant emotion faster than reappraisal:Neural dynamics in a Chinese sample显示文摘The timing dynamics of regulating negative emotion with expressive suppression and cognitive reappraisal were investigated in a Chinese sample. Event-Related Potentials were recorded while subjects were required to view, suppress emotion expression to, or reappraise emotional pictures. The results showed a similar reduction in self-reported negative emotion during both strategies. Additionally, expressive suppression elicited larger amplitudes than reappraisal in central-frontal P3 component(340–480 ms). More importantly, the Late Positive Potential(LPP) amplitudes were decreased in each 200 ms of the 800–1600 ms time intervals during suppression vs. viewing conditions. In contrast, LPP amplitudes were similar for reappraisal and viewing conditions in all the time windows, except for the decreased amplitudes during reappraisal in the 1400–1600 ms. The LPP(but not P3) amplitudes were positively related to negative mood ratings, whereas the amplitudes of P3, rather than LPP, predict self-reported expressive suppression. These results suggest that expressive suppression decreases emotion responding more rapidly than reappraisal, at the cost of greater cognitive resource involvements in Chinese individuals. | YUAN JiaJin LONG QuanShan DING NanXiang LOU YiXue LIU YingYing YANG JieMin | 2015 | Science China(Life Sciences)2015，58，5： | 11 |
| 12 | Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema显示文摘 | Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang Dai Huaping Wang Chen | 2014 | Chinese Medical Journal2014，，3： | 10 |
| 13 | 胃镜联合胆道镜在腹腔镜胆总管探查术中的应用(英文)显示文摘目的:通过探讨胃镜联合胆道镜在腹腔镜胆总管探査术(LCBDE)中的应用,为胆总管结石的手术治疗提供更多的手术方式,改善患者生活质量,降低手术难度。创新点:摒弃了以往LCBDE术后需行T管引流的方式,以鼻胆管代替T管,改善患者生活质量。同时胃镜的操作难度较内镜逆行胰胆管造影(ERCP)低。因此,本手术方式可以得到更好的推广。方法:研究对象为2017年7月1日至2017年10月30日于浙江大学医学院附属邵逸夫医院就诊的胆总管结石患者。收集这些患者的年龄、性别等临床数据,排除那些不能耐受麻醉、患急性胰腺炎及急性胆管炎、并发肝内胆管结石及胆总管结石呈泥沙状或者絮状的患者。对患者行胃镜联合胆道镜的LCBDE手术,统计其手术时长、术中出血量、术后并发症、术后住院时长以及住院花费。结论:胃镜联合胆道镜放置鼻胆管在预防LCBDE术后胆漏上切实有效,且由于术后无需留置T管,对患者的生活质量有所改善。同时,本手术方式对手术操作技术的要求较低,对于初学胆总管一期缝合的医师来说,可降低其术后胆漏的概率。 | Song-mei LOU Min ZHANG Zheng-rong WU Gui-xing JIANG Hua SHEN Yi DAI Yue-long LIANG Li-ping CAO Guo-ping DING | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，11： | 8 |
| 14 | Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games显示文摘BACKGROUND:Beijing 2022 Olympic Winter Games was the second Games held amid the COVID-19 pandemic.To a certain extent,it has altered the way sporting activities operate.There is a lack of knowledge on injury risk and illness occurrence in elite winter sport athletes amid the COVID-19 pandemic.This study aimed to describe the incidence of injuries and illnesses sustained during the XXIV Olympic Winter Games in Beijing from February 4 to 20,2022.METHODS:We recorded the daily number of injuries and illnesses among athletes reported by Beijing 2022 medical staff in the polyclinic,medical venues,and ambulance.We calculated injury and illness incidence as the number of injuries or illnesses occurring during competition or training,respectively,with incidence presented as injuries/illnesses per 100 athlete-days.RESULTS:In total,2,897 athletes from 91 nations experienced injury or illness.Beijing 2022 medical staff reported 326 injuries and 80 illnesses,equaling 11.3 injuries and 2.8 illnesses per 100 athletes over the 17-day period.Altogether,11%of the athletes incurred at least one injury and nearly 3%incurred at least one illness.The number of injured athletes was highest in the skating sports(n=104),followed by alpine skiing(n=53),ice track(n=37),freestyle skiing(n=36),and ice hockey(n=35),and was the lowest in the Nordic skiing disciplines(n=20).Of the 326 injuries,14(4.3%)led to an estimated absence from training or competition of more than 1 week.A total of 52 injured athletes were transferred to hospitals for further care.The number of athletes with illness(n=80)was the highest for skating(n=33)and Nordic skiing(n=22).A total of 50 illnesses(62.5%)were admitted to the department of dentistry/ophthalmology/otolaryngology,and the most common cause of illness was other causes,including preexisting illness and medicine(n=52,65%).CONCLUSION:Overall,11%of athletes incurred at least one injury during the Games,which is similar to the findings during the Olympic Winter Games in 2014 and 2018.Regarding illness,2%of athletes were affected,which is approximately one-third of the number affected in the 2018 Olympic Winter Games. | Peng-da Han Ding Gao Jie Liu Jing Lou Si-jia Tian Hui-xin Lian Sheng-mei Niu Lu-xi Zhang Yong Wang Jin-jun Zhang | 2022 | World Journal of Emergency Medicine2022，13，6： | 7 |
| 15 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update on organizational stroke management显示文摘Aim Stroke is characterised by high morbidity,mortality and disability,which seriously affects the health and safety of the people.Stroke has become a serious public health problem in China.Organisational stroke management can significantly reduce the mortality and disability rates of patients with stroke.We provide this evidence-based guideline to present current and comprehensive recommendations for organisational stroke management.Methods A formal literature search of MEDLINE(1 January 1997 through 30 September 2019)was performed.Data were synthesised with the use of evidence tables.Writing group members met by teleconference to discuss data-derived recommendations.The Chinese Stroke Association’s Levels of Evidence grading algorithm was used to grade each recommendation.results Evidence-based guidelines are presented for the organisational management of patients presenting with stroke.The focus of the guideline was subdivided into prehospital first aid system of stroke,rapid diagnosis and treatment of emergency in stroke centre,organisational management of stroke unit and stroke clinic,construction of regional collaborative network among stroke centres and evaluation and continuous improvement of stroke medical quality.Conclusions The guidelines offer an organisational stroke management model for patients with stroke which might help dramatically. | Min Lou Jing Ding Bo Hu Yusheng Zhang Hao Li ZeFeng Tan Yan Wan An-Ding Xu Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 7 |
| 16 | Lijiang 2.4-meter Telescope and its instruments显示文摘The Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China,has been available to the worldwide astronomical community since 2008. It is located at the Gaomeigu site,Lijiang Observatory(LJO), in the southwest of China. The site has very good observational conditions.During its 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include recording photometric and spectral evolution of supernovae, reverberation mapping of active galactic nuclei, investigating the physical properties of binary stars and near-earth objects(comets and asteroids), and identification of exoplanets and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernovae have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation conditions of the Gaomeigu site is introduced at first. Then, the structure of the LJT is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized. | Chuan-Jun Wang Jin-Ming Bai Yu-Feng Fan Ji-Rong Mao Liang Chang Yu-Xin Xin Ju-Jia Zhang Bao-Li Lun Jian-Guo Wang Xi-Liang Zhang Mei Ying Kai-Xing Lu Xiao-Li Wang Kai-Fan Ji Ding-Rong Xiong Xiao-Guang Yu Xu Ding Kai Ye Li-Feng Xing Wei-Min Yi Liang Xu Xiang-Ming Zheng Yuan-Jie Feng Shou-Sheng He Xue-Li Wang Zhong Liu Dong Chen Jun Xu Song-Nian Qin Rui-Long Zhang Hui-Song Tan Zhi Li Ke Lou Jian Li Wei-Wei Liu | 2019 | Research in Astronomy and Astrophysics2019，19，10： | 4 |
| 17 | Correlations of PCBs, DIOXIN, and PBDE with TSH in Children's Blood in Areas of Computer E-waste Recycling显示文摘Objective To study correlations of polychlorinated biphenyls (PCBs), DIOXIN, and polybrominated diphenyl ethers (PBDE) with thyroid stimulating hormone(TSH) in children, and assess the impact on children's health. Methods Three hundred and sixty nine children aged from 6 to 8, including 195 from Luqiao, the computer E‐waste recycling area, and 174 from Longyou, the control area, were selected for this investigation to elucidate the correlation of PCBs, DIOXIN, and PBDE with TSH in children's blood samples. The children had a physical examination and their blood levels of PCBs, DIOXIN, PBDE, and TSH were detected after sample collection. Results In the E‐waste recycling area, the contents of PCBs, PBDE, DIOXIN, and TSH in the blood samples of children were 484.00±84.86 ng·g ‐1 lipid weight, 664.28±262.38 ng·g ‐1 lipid weight, 26.00±19.58 ng·g ‐1 lipid weight and 1.88±0.42 μIU/mL (serum) respectively, while in the control area, the PCBs, PBDE, DIOXIN, and TSH contents were 255.38±95 ng·g ‐1 lipid weight, 375.81±262.43 ng·g ‐1 lipid weight, 39.64±31.86 ng·g ‐1 lipid weight, and 3.31±1.04 μIU/mL respectively. Conclusion The health status of children in the control area are better than that in the contaminated area. Among children who are exposed to persistent organic pollutants, the pollutant content increases significantly in their serum, and the distribution of TSH levels in their bodies are also affected. | HAN GuanGen DING GangQiang LOU XiaoMing WANG XiaoFeng HAN JianLong SHEN HaiTao ZHOU Yu DU LeYan | 2011 | Biomedical and Environmental Sciences2011，24，2： | 4 |
| 18 | Scavenging reactive oxygen species is a potential strategy to protect Larimichthys crocea against environmental hypoxia by mitigating oxidative stress显示文摘The large yellow croaker(Larimichthys crocea),which is an economically important mariculture fish in China,is often exposed to environmental hypoxia.Reactive oxygen species(ROS)homeostasis is essential for the maintenance of normal physiological conditions in an organism.Direct evidence that environmental hypoxia leads to ROS overproduction is scarce in marine fish.Furthermore,the sources of ROS overproduction in marine fish under hypoxic stress are poorly known.In this study,we investigated the effects of hypoxia on redox homeostasis in L.crocea and the impact of impaired redox homeostasis on fish.We first confirmed that hypoxia drove ROS production mainly via the mitochondrial electron transport chain and NADPH oxidase complex pathways in L.crocea and its cell line(large yellow croaker fry(LYCF)cells).We subsequently detected a marked increase in the antioxidant systems of the fish.However,imbalance between the pro-oxidation and antioxidation systems ultimately led to excessive ROS and oxidative stress.Cell viability showed a remarkable decrease while oxidative indicators,such as malondialdehyde,proteincarbonylation,and8-hydroxy-2 deoxyguanosine,showed a significant increase after hypoxia,accompanied by tissue damage.Nacetylcysteine(NAC)reduced ROS levels,alleviated oxidative damage,and improved cell viability in vitro.Appropriate uptake of ROS scavengers(e.g.,NAC and elamipretide Szeto-Schiller-31)and inhibitors(e.g.,apocynin,diphenylene iodonium,and 5-hydroxydecanoate)may be effective at overcoming hypoxic toxicity.Our findings highlight previously unstudied strategies of hypoxic toxicity resistance in marine fish. | Sheng-Yu Luo Cheng Liu Jie Ding Xin-Ming Gao Jing-Qian Wang Yi-Bo Zhang Chen Du Cong-Cong Hou Jun-Quan Zhu Bao Lou Xiong-Fei Wu Wei-Liang Shen | 2021 | Zoological Research2021，42，5： | 3 |
| 19 | Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer显示文摘High infiltration of M2-polarized macrophages in the primary tumor indicates unfavorable prognosis and poor overall survival in the patients with triple-negative breast cancer(TNBC).Thus,reversing M2-polarized tumor-associated macrophages in the tumors has been considered as a potential therapeutic strategy for TNBC.Sphingomyelin synthase 2(SMS2)is the key enzyme for sphingomyelin production,which plays an important role in plasma membrane integrity and function.In this study we investigated whether SMS2 inhibitor or SMS2 gene knockout could reduce macrophages M2 polarization and tumor progression in a mouse model of TNBC.We showed that SMS2 mRNA expression was linked to immunosuppressive tumor microenvironment and poor prognosis in TNBC patients.The knockout of SMS2 or application of 15w(a specific SMS2 inhibitor)markedly decreased the generation of M2-type macrophages in vitro,and reduced the tumor weight and lung metastatic niche formation in a 4T1-TNBC mouse model.We further demonstrated that the in vivo antitumor efficacy of 15w was accompanied by a multifaceted remodeling of tumor immune environment reflecting not only the suppression of M2-type macrophages but also diminished levels of regulatory T cells and myeloid-derived suppressor cells leading to a dramatically improved infiltration of antitumor CD8+T lymphocytes.Collectively,our results reveal a novel and important role of SMS2 in the protumorigenic function and may offer a new strategy for macrophage-targeted anticancer therapy. | Yan Deng Jia-chun Hu Shu-hua He Bin Lou Ting-bo Ding Jin-tong Yang Ming-guang Mo De-yong Ye Lu Zhou Xian-cheng Jiang Ker Yu Ji-bin Dong | 2021 | Acta Pharmacologica Sinica2021，42，1： | 2 |
| 20 | Perturbed proximal point algorithms for general quasi-variational-like inclusions显示文摘 | Ding X P Lou C L | 2000 | J Comput Appl Math2000，113，： | 2 |
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