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| 1 | Effects of dietary cottonseed meal protein hydrolysate on growth,antioxidants and immunity of Chinese mitten crab Eriocheir Sinensis显示文摘One hundred and sixty crabs(average initial weight:51.32±0.08 g)were fed with four experimental diets containing cottonseed meal protein hydrolysate(CPH)at 0%(CPH0,control),0.3%(CPH0.3),0.6%(CPH0.6),and 1.2%CPH(CPH1.2).The experiment results show that no difference was observed in specific growth rate and survival rate of crabs fed with CPH diet.Moisture content of crabs fed with CPH0.6 diet was significantly reduced than that of the CPH0 group.Superoxide dismutase and catalase activities of crabs fed with CPH0.6 diet were significantly increased and the difference was not significant between the CPH0.3 and CPH0.6 groups.Malondialdehyde content of CPH0.3 group was significantly lower than that of the CPH0 group.Lysozyme,alkaline phosphatase,and acid phosphatase activities of CPH0.3 diet crabs were significantly higher than that of the CPH0 group.Glutamic-pyruvic transaminase activity of crabs fed with CPH0.3 diet was significantly decreased compared to the CPH0 group.The relative expression levels of Toll1,Toll2,MyD88,LITAF,and ILF-2 of crabs fed with CPH0.3 diet were significantly higher than that of the CPH0 group.The expression level of SOCS2 showed an opposite pattern.After CPH perfusion,the expression levels of SOCS2 and Toll1 in intestine at time 3 h and SOCS2 in hepatopancreas at time 18 h increased significantly to the highest value.The expression level of Toll2,MyD88,LITAF,decreased at times 6 h,6 h,12 h,respectively,then increased gradually.Therefore,supplementation of dietary CPH could improve antioxidant capacity and immune function;the appropriate supplement dosage of CPH for crab could be 0.3%-0.6%.Furthermore,the short-term CPH stimulation could significantly increase or decline the expression levels of immune-related genes at different times after CPH perfusion. | CHENG Huihui LIU Wenbin YUAN Xiangyang JIA Erteng ZHANG Dingdong JIANG Guangzhen | 2020 | Journal of Oceanology and Limnology2020，38，3： | 2 |
| 2 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | CAO Yunxing HE Dingdong GLICK DAVID C | 2001 | International Journal of Coal Geology2001，48，2： | 1 |
| 3 | Link between miR-19b and the mTOR signaling pathway in cancer prognosis显示文摘Objective Previous studies have reported differing conclusions regarding the prognostic value of miR-19b in cancers.Moreover,miR-19b may affect tumor growth by different pathways,mainly targeting PTENPI3K-AKT,which activates the downstream mTOR pathway.Therefore,we performed data mining to explore the possible correlation between miR-19b and mTOR in cancer prognosis.Methods We conducted online search and collected a total of 943 articles.According to different authors cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this meta-analysis.Then TCGA data containing miR-19b level with cancer progression were obtained using OncomiR.Furthermore,Trial Sequential Analysis(TSA)was performed to determine whether the results of our meta-analysis could be used in clinical applications.After that,articles regarding the mechanism of miR-19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory function of miR-19b in human cancers.Results Overall hazard ratio(HR)results showed that higher levels of miR-19b expression were correlated with shorter overall survival time[HR=1.54,95%confidence interval(CI)=1.20-1.98]by promoting distant metastasis,but had no correlation with disease-free survival(DFS)/progression-free survival(PFS;HR=0.61,95%CI=0.31–1.19).Data from The Cancer Genome Atlas also revealed the role of miR-19b in tumorigenesis.According to trial sequential analysis results,more evidence is required to confirm that miR-19b is not correlated with DFS/PFS.Exploration of the mechanism revealed a possible link between miR-19b and the mTOR pathway.Conclusion miR-19b may have a pro-carcinogenic role through the mTOR pathway and thus,it is likely to be a therapeutic target for cancers. | Yanlin Feng Souraka Tapara Dramani Maman Shuo Li Dingdong He Jiancheng Tu | 2020 | Oncology and Translational Medicine2020，6，4： | 1 |
| 4 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Yunxing Cao Dingdong He David C Glick | 2001 | International Journal of Coal Geology2001，，1： | 1 |
| 5 | The PoincaréBertrand formula on the building domain of the complex biballs显示文摘 | Gong Dingdong Lin Liangyu | 2010 | Acta Mathematica Scientia:Ser B2010，30，34： | 1 |
| 6 | Singular integral on bounded strictly pseudoconvex domain显示文摘 | Gong Dingdong | 2008 | Applied Mathematics A Journal of Chinese Universities:Ser B2008，23，27： | 1 |
| 7 | Drug discovery of sclerostin inhibitors显示文摘Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy. | Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 8 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Cao Yunxing He Dingdong David C Gliek | 2001 | International Journal of Coal Geology2001，，48： | 1 |
| 9 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Yunxing Cao Dingdong He David C Glick | 2001 | International Journal of Coal Geology2001，，1： | 1 |
| 10 | Coal and gas outbursts in footwalls of reverse faults 显示文摘 | Cao Yunxing He Dingdong Glick David C | 2001 | International Journal of Coal Geology2001，，48： | 1 |
| 11 | Tribological Performance and Action Mechanism of S-Alkyl and S-Benzimidazole Substituted Diakyldithiocarbamates显示文摘 | Dingdong Xu Yang Wan | 2000 | Wear2000，241，1： | 1 |
| 12 | Coal and gas out- bursts in footwalls of reverse faults显示文摘 | CAO Yunxing HE Dingdong DAVID C G | 2001 | International Journal of Coal Geology2001，48，12： | 1 |
| 13 | , Microencapsulation of emulsified hydrophobie flavors by spray drying 显示文摘 | Liu Dingdong Takuroh Atarashi Takeshi Furuta | 2001 | Drying Technology2001，19，7： | 1 |
| 14 | Aquafeed fermentation improves dietary nutritional quality and benefits feeding behavior,meat flavor,and intestinal microbiota of Chinese mitten crab(Eriocheir sinensis)显示文摘Normally,proper fermentation can be an efficient and widely used method to improve feed quality in animal rearing;however,the studies on crustaceans,especially Eriocheir sinensis,remain limited.This study aimed to investigate whether feed fermentation could meliorate dietary nutritional value and benefit E.sinensis rearing.First,non-fermented feed(NFD)and fermented feed(FD)were produced and assessed,respectively.Then,the“Y”maze feed choice behavior test(180 times;30 times,6 rounds)was conducted to assess the attractiveness of these 2 feeds for crabs.Finally,a total of 80 crabs(44.10±0.80 g)were randomly assigned into 2 groups with 4 replicates,and fed the experimental diets for 8 weeks to evaluate the effects of each feed on growth,antioxidant capacity,meat flavor,and intestinal microbiota.In this study,FD showed higher levels of crude protein(P<0.01),soluble protein(P<0.01),amino acids(P<0.05),lactic acid(P<0.001),and lower levels of crude fiber(P<0.05)and antinutritional factors(agglutinin,trypsin inhibitor,glycinin,andβ-conglycinin)(P<0.001)than NFD.Additionally,FD was more attractive to crabs than NFD(P<0.01)and it stimulated the appetite of crabs more than NFD(P<0.05).The growth performance,feed efficiency,and digestive enzyme activity of FDfed crabs were significantly higher than those of NFD-fed crabs(P<0.05).The electronic sensory measurements and free amino acid profiles revealed that the FD diet had positive impacts on the meat flavor of crabs,particularly in“sweet”and“umami”tastes.Moreover,the antioxidant capacity of FD-fed crabs was significantly higher than that of NFD-fed crabs(P<0.05).Fermented feed also affected the diversity and composition of intestinal microflora.The functional prediction of microbial communities showed that crabs fed FD had a better microecological environment in the intestine.In conclusion,the fermentation of aquafeed could be an effective approach to enhance feed quality and therefore benefit E.sinensis rearing. | Weibo Jiang Xiaoyan Jia Ningjun Xie Chuang Wen Shuo Ma Guangzhen Jiang Xiangfei Li Cheng Chi Dingdong Zhang Wenbin Liu | 2023 | Animal Nutrition2023，，3： | 0 |
| 15 | Anisotropic 2D materials for post-Moore photoelectric devices显示文摘Since the discovery of two-dimensional(2D)graphene[1],2D materials have been widely investigated due to their in-triguing physical/chemical property and outstanding optoelec-tronic performance[1−3].Generally,2D materials can be di-vided into isotropy and anisotropy according to crystal struc-tures.For isotropic 2D materials like graphene and hexagon-al boron nitride,they have obvious lattice symmetry.Where-as,anisotropic 2D materials possess strong anisotropic crys-tal structure(Fig.1(a)),providing new degree of freedom for exploring 2D materials.Currently,2D materials with high aniso-tropy,due to their anisotropic electrical,optical,thermal,and phonon properties,are finding applications in polarization-sensitive photodetection,neural network construction,spin-polarized transport and other emerging fields[3−6]. | Dingdong Xie Jie Jiang Liming Ding | 2022 | Journal of Semiconductors2022，43，1： | 0 |
| 16 | Germ cell-specific deletion of Pex3 reveals essential roles of PEX3-dependent peroxisomes in spermiogenesis显示文摘Peroxisomes are organelles enclosed by a single membrane and are present in various species.The abruption of peroxisomes is correlated with peroxisome biogenesis disorders and single peroxisomal enzyme deficiencies that induce diverse diseases in different organs.However,little is known about the protein compositions and corresponding roles of heterogeneous peroxisomes in various organs.Through transcriptomic and proteomic analyses,we observed heterogenous peroxisomal components among different organs,as well as between testicular somatic cells and different developmental stages of germ cells.As Pex3 is expressed in both germ cells and Sertoli cells,we generated Pex3 germ cell-and Sertoli cell-specific knockout mice.While Pex3 deletion in Sertoli cells did not affect spermatogenesis,the deletion in germ cells resulted in male sterility,manifested as the destruction of intercellular bridges between spermatids and the formation of multinucleated giant cells.Proteomic analysis of the Pex3-deleted spermatids revealed defective expressions of peroxisomal proteins and spermiogenesis-related proteins.These findings provide new insights that PEX3-dependent peroxisomes are essential for germ cells undergoing spermiogenesis,but not for Sertoli cells. | Yejin Yao Baolu Shi Xiangzheng Zhang Xin Wang Shuangyue Li Ying Yao Yueshuai Guo Dingdong Chen Bing Wang Yan Yuan Jiahao Sha Xuejiang Guo | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 17 | Research on High Precision Autonomous Navigation of Shared Balancing Vehicles Based on EKF-SLAM显示文摘In view of the technical difficulties of autonomous navigation in local areas,this paper proposes a high-precision autonomous navigation shared bal-ancing bike system based on EKF-SLAM.This system uses the EKF-SLAM algorithm in robot localization to achieve simultaneous localization and map con-struction using the extended Kalmanfilter.At the same time,GPS and IMU are also employed for absolute positioning,and point cloud matching is used for rel-ative positioning to achieve multisensor fusion positioning.For the convenience of users,this system uses the RNN-T model for speech recognition destinations.Through experimental verification,the EKF-SLAM-based autonomous naviga-tion technology proposed in this paper can meet the accurate localization service and can realize the function of high precision autonomous navigation and voice recognition of destinations for shared balancing vehicles in a local area. | Xinyu Cheng Yanqing Wang Dingdong Guo Xuewei Li Yiming Gao | 2023 | 国际计算机前沿大会会议论文集2023，，2： | 0 |
| 18 | Identifying nasopharyngeal carcinoma patients with metachronous metastasis sensitive to local treatment:a real-world study显示文摘It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted. | Fanyu Peng Yizhi Ge Rongrong Wang Dingdong Hu Xiang Cao Yujie Zhang Dan Zong Xia He | 2022 | The Journal of Biomedical Research2022，36，4： | 0 |
| 19 | Stably doped graphene transparent electrode with improved lightextraction for efficient flexible organic light-emitting diodes显示文摘Graphene-based flexible transparent electrodes(FTEs)are promising candidate materials for developing next-generation flexible organic light-emitting diodes(OLEDs).However,the quest for high-efficiency OLEDs is hindered by the low light-extraction and charge injection efficiencies of graphene electrode.Here,we combine the frustrated Lewis pair doping with nanostructure engineering to obtain high-performance graphene FTE.A p-type dopant aci-nitromethane-tris(pentafluorophenyl)borane(ANBCF)was synthesized and deposited on graphene FTE to form an aperiodic nanostructure,which not only improves the light-extraction but also stably p-dopes graphene to enhance its hole injection.The use of ANBCF-doped graphene as the anode enables high-efficiency flexible green OLEDs with external quantum efficiency(EQE)and power efficiency(PE)out-performing most flexible graphene OLEDs of comparable structure.This study provides a simple and effective pathway to fabricate high-performance graphene FTEs for efficient flexible OLEDs. | Lai-Peng Ma Zhongbin Wu Yukun Yan Dingdong Zhang Shichao Dong Jinhong Du Dongge Ma Hui-Ming Cheng Wencai Ren | 2023 | Nano Research2023，16，11： | 0 |
| 20 | Study of GaAlAs/GaAs Planar Lightwave Filters显示文摘Based on the theory of four-port resonator filters, the characteristics of four kinds of filters with single race-track, dual race-track, rectangular and MMI resonators respectively were numerically simulated by utilizing two-dimensional FDTD method. The relationship between the number of cascade resonators and the filtering features was also analyzed. A kind of narrow-band filters with four cascade resonators implemented on GaAlAs/GaAs planar lightwave circuits were designed and fabricated. The measurement result shows that the half-width of such filters is about 10nm, which coincides well with the numeric computation. | CaiChun LiuXu XiaoJinbiao MaChangfeng DingDong ZhangMingde SunXiaohan XuXiaole ChenTangsheng LiFuxiao | 2005 | 工程科学(英文版)2005，3，1： | 0 |
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