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| 1 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | CAO Yunxing HE Dingdong GLICK DAVID C | 2001 | International Journal of Coal Geology2001，48，2： | 1 |
| 2 | Link between miR-19b and the mTOR signaling pathway in cancer prognosis显示文摘Objective Previous studies have reported differing conclusions regarding the prognostic value of miR-19b in cancers.Moreover,miR-19b may affect tumor growth by different pathways,mainly targeting PTENPI3K-AKT,which activates the downstream mTOR pathway.Therefore,we performed data mining to explore the possible correlation between miR-19b and mTOR in cancer prognosis.Methods We conducted online search and collected a total of 943 articles.According to different authors cross check and our study including/excluding criteria we at end retained 21 articles with 25 studies in this meta-analysis.Then TCGA data containing miR-19b level with cancer progression were obtained using OncomiR.Furthermore,Trial Sequential Analysis(TSA)was performed to determine whether the results of our meta-analysis could be used in clinical applications.After that,articles regarding the mechanism of miR-19b in various cancers were analyzed and KEGG pathway database was used to find the main regulatory function of miR-19b in human cancers.Results Overall hazard ratio(HR)results showed that higher levels of miR-19b expression were correlated with shorter overall survival time[HR=1.54,95%confidence interval(CI)=1.20-1.98]by promoting distant metastasis,but had no correlation with disease-free survival(DFS)/progression-free survival(PFS;HR=0.61,95%CI=0.31–1.19).Data from The Cancer Genome Atlas also revealed the role of miR-19b in tumorigenesis.According to trial sequential analysis results,more evidence is required to confirm that miR-19b is not correlated with DFS/PFS.Exploration of the mechanism revealed a possible link between miR-19b and the mTOR pathway.Conclusion miR-19b may have a pro-carcinogenic role through the mTOR pathway and thus,it is likely to be a therapeutic target for cancers. | Yanlin Feng Souraka Tapara Dramani Maman Shuo Li Dingdong He Jiancheng Tu | 2020 | Oncology and Translational Medicine2020，6，4： | 1 |
| 3 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Yunxing Cao Dingdong He David C Glick | 2001 | International Journal of Coal Geology2001，，1： | 1 |
| 4 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Cao Yunxing He Dingdong David C Gliek | 2001 | International Journal of Coal Geology2001，，48： | 1 |
| 5 | Coal and gas outbursts in footwalls of reverse faults显示文摘 | Yunxing Cao Dingdong He David C Glick | 2001 | International Journal of Coal Geology2001，，1： | 1 |
| 6 | Coal and gas outbursts in footwalls of reverse faults 显示文摘 | Cao Yunxing He Dingdong Glick David C | 2001 | International Journal of Coal Geology2001，，48： | 1 |
| 7 | Coal and gas out- bursts in footwalls of reverse faults显示文摘 | CAO Yunxing HE Dingdong DAVID C G | 2001 | International Journal of Coal Geology2001，48，12： | 1 |
| 8 | Identifying nasopharyngeal carcinoma patients with metachronous metastasis sensitive to local treatment:a real-world study显示文摘It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted. | Fanyu Peng Yizhi Ge Rongrong Wang Dingdong Hu Xiang Cao Yujie Zhang Dan Zong Xia He | 2022 | The Journal of Biomedical Research2022，36，4： | 0 |
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