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| 1 | Tuberculous peritonitis in children:Report of nine patients and review of the literature显示文摘AIM:To present our experience with tuberculous peritonitis treated in our hospital from 2002-2007. METHODS: We reviewed the medical records of 9 children with tuberculous peritonitis. RESULTS: Nine patients (5 boys, 4 girls) of mean age 14.2 years were diagnosed with peritoneal tuberculosis. All patients presented with abdominal distention. Abdominal pain was seen in 55.5% and fever in 44.4% of the patients. Four cases had coexisting pleural effusion and two had pulmonary tuberculosis with parenchymal consolidation. Ultrasonography found ascites with septation in 7 patients. Two patients had only ascites without septation. Ascitic fluid analysis of 8 patients yielded serum-ascite albumin gradients of less than 1.1 gr/dL. Laparoscopy and laparotomy showed that whitish tuberculi were the most common appearance. Adhesions were also seen in three cases. The diagnosis of peritoneal tuberculosis was confirmed histo-pathologically in 7 patients and microbiologically in two. Two patients had been diagnosed by ascitic fluid diagnostic features and a positive response to antituberculous treatment. All patients completed the antituberculous therapy without any complications. CONCLUSION: Tuberculous peritonitis has to be clinically suspected in all patients with slowly progressive abdominal distension, particularly when it is accompanied by fever and pain. Laparoscopy and peritoneal biopsy are still the most reliable, quick and safe methods for the diagnosis of tuberculous peritonitis. | Gnül Dinler Gülnar Sensoy Deniz Helek Ayhan Gazi Kalayc■ | 2008 | World Journal of Gastroenterology2008，14，47： | 8 |
| 2 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 3 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 4 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 5 | A new low-correlation MCP (measurement- correlate-predict) method for wind energy forecasting 显示文摘 | Ali Dinler | 2013 | Energy2013，63，10： | 1 |
| 6 | The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs显示文摘 | Levent Doganay Ilyas Tuncer Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Gizem Dinler | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，： | 1 |
| 7 | Acute pancreatitis as a presenting feature of Henoch-Schonlein purpura显示文摘 | Dinler G Bek K Aqikgoz Y Kalayci AG | 2010 | Turk J Pedi- atr2010，52，2： | 1 |
| 8 | Acute pancreatitis as a pre-senting feature of Henoch- Sch?nlein purpura显示文摘 | Dinler G Bek K A0kgoz Y et ai | 2010 | Turk J Pediatr2010，52，2： | 1 |
| 9 | Acute pancreatitis as a presenting feature of Henoch-Schonlein purpura显示文摘 | Dinler G Bek K Acikgoz Y | 2010 | Turk J Pediatr2010，52，2： | 1 |
| 10 | Acute pancreatitis as a presenting feature of Henoch-Schonlein purpura显示文摘 | Dinler G Bek K Acikgoz Y | 2010 | Turk J Pediatr2010，52，2： | 1 |
| 11 | A new method to estimate Weibull parameters for wind energy applications 显示文摘 | Akdag Seyit A Dinler Ali | 2009 | Energy Conversion and Management2009，50，7： | 1 |
| 12 | Heuristics for a continuous multi-facility location problem with demand regions显示文摘 | Dinler D Tural M K Iyigun C | 2015 | Com- puters & Operations Research2015，62，： | 1 |
| 13 | A new method to estimate Weibull parameters for wind energy applications显示文摘 | Seyit A A Dinler A | 2009 | Energy Conversion and Management2009，，50： | 1 |
| 14 | The effect of an intraperitoneal injection of melatonin on serum amylase levels in acute pancreatitis 显示文摘 | C61 C Dinler K Hasdemir AO | 2009 | JOP2009，10，3： | 1 |
| 15 | Evaluation of the effects of melatonin administration intraperitoncally on rats with acute pancreatitis induced by duetal ligation 显示文摘 | Gtil C Dinler K Hasdemir AO | 2010 | Turk J Gastroenterol2010，21，4： | 1 |
| 16 | Exogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute panereatitis 显示文摘 | Gtl C Dinler K Hasdemir AO | 2010 | J Hepatobiliary Panereat Sei2010，17，5： | 1 |
| 17 | Acute pancreatitis as a pre-senting feature of Henoch- Sch?nlein purpura显示文摘 | Dinler G Bek K A0kgoz Y et ai | 2010 | Turk J Pediatr2010，52，2： | 1 |
| 18 | A new method to estimate Weibull parameters for wind energy applications显示文摘 | Seyit A Akdaga Dinler A | | 0，，50： | 1 |
| 19 | Duodenal nodularity in children:A clinical and pathologic study of 17 cases显示文摘 | Caltepe Dinler Gǒnül Can Bilge Kalayct Ayhan Gazi | | 0，，02： | 1 |
| 20 | Acute pancreatitis as a presenting feature of Henoch-Sch(o)nlein purpura显示文摘 | Dinler G Bek K Acikg(o)z Y | | 0，，02： | 1 |
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