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| 1 | Effect of asymmetric rolling process on the microstructure,mechanical properties and texture of AZ31 magnesium alloys sheets produced by twin roll casting technique显示文摘Symmetric rolling(SR)and asymmetric rolling(ASR)processes were carried out on 6 mm thick AZ31 magnesium alloy sheets that were produced by twin roll casting(TRC)technique.Before rolling processes,sheets were heat treated in order to obtain a homogenized microstructure.In this study,for the ASR process the rolling speed ratio between upper roller and lower was selected as 1.25.Both SR and ASR processes were utilized with 40%reduction per passes using 2 pass schedule for a total reduction ratio of 0.67.Symmetric and asymmetric rolled sheets were characterized using optical microscopy(OM),scanning electron microscopy(SEM)and transmission electron microscopy(TEM)techniques.Texture measurements were performed by using X-ray diffraction(XRD)technique and mechanical properties were investigated by tensile tests and also hardness measurements. | Selda Ucuncuoglu Ahmet Ekerim Gizem Oktay Secgin Ozgur Duygulu | 2014 | Journal of Magnesium and Alloys2014，2，1： | 11 |
| 2 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 3 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 4 | Versatile rigid-fluid coupling for incompressible SPH显示文摘 | Nadir Akinci Markus Ihmsen Gizem Akinci Barbara Solenthaler Matthias Teschner | 2012 | ACM Transactions on Graphics (TOG)2012，，4： | 3 |
| 5 | Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis显示文摘Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved.Adipose-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and pluripotency.AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics.They are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells.It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression.These advantages have popularized its use in many fields including plastic reconstructive surgery.However,in the field of hepatology and liver transplantation,the progress is slower.AD-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract regeneration.These are very important for the treatment of various hepatobiliary diseases.Furthermore,the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis.We need alternative therapeutic approaches to treat end-stage liver failure.AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation.Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis. | Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz | 2022 | World Journal of Clinical Cases2022，10，14： | 1 |
| 6 | The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs显示文摘 | Levent Doganay Ilyas Tuncer Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Gizem Dinler | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，： | 1 |
| 7 | A review of services and interventions for runaway and homeless youth: Moving forward显示文摘 | Natasha Slesnick Pushpanjali Dashora Amber Letcher Gizem Erdem Julianne Serovich | 2009 | Children and Youth Services Review2009，，7： | 1 |
| 8 | Strategic analysis of heahhcare service quality using fuzzy AHP methodology显示文摘 | Gtilcin B Gizem C Sezin G | 2011 | Expert Syst App12011，38，8： | 1 |
| 9 | A new multiobjective simulated annealing algorithm显示文摘 | Ozan Tekinalp Gizem Karsli | 2007 | Journal of Global Optimization2007，，： | 1 |
| 10 | Versatile Rigid- Fluid Coupling for Incompressible SPH 显示文摘 | Nadir Akinci Markus Ihmsen Gizem Akinci | 2012 | ACM Transactions on Graphics (S0730-0301)2012，31，4： | 1 |
| 11 | Sustainable development in historic areas: Adaptive re-use challenges in traditional houses in Sanliurfa,Turkey显示文摘 | McahitYildirim Gizem Turan | 2012 | Habitat International2012，36，4： | 1 |
| 12 | Origin-destination missing data estimation for freight transportation planning: a gravity model-based regression approach显示文摘 | Guo A Shen Q Gizem S | 2014 | General Information2014，37，6： | 1 |
| 13 | SIRT1 and SIRT2:emerging targets in neurodegeneration 显示文摘 | Gizem Donmezl Tiago F | 2013 | Mol Med2013，，5： | 1 |
| 14 | A combined fuzzy AHP and fuzzy TOPSIS based strategic analysis of electronic service quality in healthcare industry显示文摘 | Gül?in Büyük?zkan Gizem ?if?i | 2011 | Expert Systems With Applications2011，，3： | 1 |
| 15 | Analysis of the electrochemical reaction behavior of alloy AZ91 by EIS technique in H3PO4/KOH buffered K2SO1 solutions 显示文摘 | Mustafa A Gizem C | 2007 | Corrosion Science2007，49，4： | 1 |
| 16 | SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10显示文摘 | Gizem Donmez Diana Wang Dena E. Cohen Leonard Guarente | 2010 | Cell2010，，2： | 1 |
| 17 | Strategic analysis of healtheare service quality using fuzzy AHP methodology显示文摘 | Gtilcin B Gizem C Sezin G | 2011 | Expert Syst Appl2011，38，8： | 1 |
| 18 | Analysis of Expressed Sequence Tags(ESTs) from Agrostis Species Obtained Using Sequence Related Amplified Polymorphism显示文摘 | Gizem Dinler | 2008 | Biochem Genet2008，46，： | 1 |
| 19 | Analysis of Expressed Sequence Tags (ESTs) from Agrostis Species Obtained Using Sequence Related Amplified Polymorphism显示文摘 | Gizem Dinler Hikmet Budak | 2008 | Biochemical Genetics (-)2008，，9： | 1 |
| 20 | Strategic analysis of healthcare service quality using fuzzy AHP methodology显示文摘 | Giilcin B Gizem C Sezin G | 2011 | Expert Syst App12011，38，8： | 1 |
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