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| 1 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 2 | Progesterone skin cream and measurement of absorption显示文摘 | Gambrell R Don JR | 2003 | North American Menopause Society2003，10，1： | 1 |
| 3 | Experimental characterization of processing performances relationships of resistance welded graphite/polyetheretherketone composite joints 显示文摘 | DON R C GILLESPIE J W Jr LAMBING C L T | 1992 | Polym Eng Sci1992，32，9： | 1 |
| 4 | Variable density grid - based sampling designs for continuous spatial populations 显示文摘 | Stevens Don L Jr | 1997 | Environmetrics1997，8，： | 1 |
| 5 | Variance estimation for spatially balanced samples of environmental resources显示文摘 | Stevens Don L Jr Olsen Anthony R | 2003 | Environmetrics2003，14，： | 1 |
| 6 | Pathogenesis of bronchopulmonary dysplasia显示文摘 | Don Hayes Jr David J Feola Brian S Murphy | 2010 | Respiration2010，79，： | 1 |
| 7 | The role of goal orientation following performance feed- back 显示文摘 | VandeWalle Don Cron William L Slocum John W Jr | 2001 | Journal of AppliedPsyc hology2001，86，4： | 1 |
| 8 | Variable density grid-based sampling designs for continuous spatial populations 显示文摘 | Stevens Don L Jr | 1997 | Environmetries1997，，8： | 1 |
| 9 | Stratepies to reduce the incidence of endometrial cancer in postmenopausal wonen 显示文摘 | Gambrell B Don Jr MD | 1997 | Am J Obstet Gynecol1997，177，： | 1 |
| 10 | Variable density grid-based sampling designs for continuous spatial populations 显示文摘 | Stevens Don L Jr | 1997 | Environmetrics1997，8，： | 1 |
| 11 | Environmental Holism and Individuals 显示文摘 | Don E Marietta Jr | 1988 | Environmental Ethics1988，，10： | 1 |
| 12 | Dehumidification at part load 显示文摘 | DON SllI HUGH H Jr | 2004 | ASHRAE Journal2004，46，4： | 1 |
| 13 | TRPV1 as a cough sensor and its temperature-sensitive properties显示文摘 | Lu-Yuan Lee Dan Ni Don Hayes Jr | 2011 | Pulmonary Pharmacology & Therapeutics2011，24，： | 1 |
| 14 | Synthetic lethal metabolic targeting of cellular senescence in cancer therapy显示文摘 | Don' JR Yu Y Milanovic M | 2013 | Nature2013，501，： | 1 |
| 15 | Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPVl-expressing airway afferents显示文摘 | Ruei-Lung Lin Don Hayes Jr Lu-Yuan Lee | 2009 | J Appl Physiol2009，106，6： | 1 |
| 16 | Sacral fixation technique in lumbosacral fusion显示文摘 | Don O Stovall Jr Allan G | 1986 | Spine1986，22，： | 1 |
| 17 | 希拉里的宽恕显示文摘希拉里·克林顿在丈夫性丑闻阴影袭来时,所表现出的愤怒、痛苦、挣扎让世界看到了这位坚强女性的另一面。通过坚强的信念和爱,希拉里最终做出了抉择。让我们回到那个夏天,一探这位杰出女性的心路历程。 | JEFF GERTH DON VAN NATTA JR 李维 | 2010 | 中外妇儿健康2010，，5： | 0 |
| 18 | Effect of transplant center volume on post-transplant survival in patients listed for simultaneous liver and kidney transplantation显示文摘AIM To examine the effect of center size on survival differences between simultaneous liver kidney transplantation(SLKT) and liver transplantation alone(LTA) in SLKT-listed patients.METHODS The United Network of Organ Sharing database was queried for patients ≥ 18 years of age listed for SLKT between February 2002 and December 2015. Posttransplant survival was evaluated using stratified Cox regression with interaction between transplant type(LTA vs SLKT) and center volume.RESULTS During the study period, 393 of 4580 patients(9%) listed for SLKT underwent a LTA. Overall mortality was higher among LTA recipients(180/393, 46%) than SLKT recipients(1107/4187, 26%). The Cox model predicted a significant survival disadvantage for patients receiving LTA vs SLKT [hazard ratio, hazard ratio(HR) = 2.85; 95%CI: 2.21, 3.66; P < 0.001] in centers performing 30 SLKT over the study period. This disadvantage was modestly attenuated as center SLKT volume increased, with a 3% reduction(HR = 0.97; 95%CI: 0.95, 0.99; P = 0.010) for every 10 SLKs performed.CONCLUSION In conclusion, LTA is associated with increased mortality among patients listed for SLKT. This difference is modestly attenuated at more experienced centers and may explain inconsistencies between smaller-center and larger registry-wide studies comparing SLKT and LTA outcomes. | Rohan M Modi Dmitry Tumin Andrew J Kruger Eliza W Beal Don Hayes Jr James Hanje Anthony J Michaels Kenneth Washburn Lanla F Conteh Sylvester M Black Khalid Mumtaz | 2018 | World Journal of Hepatology2018，10，1： | 0 |
| 19 | Mechanical circulatory support in lung transplantation: Cardiopulmonary bypass, extracorporeal life support, and ex-vivo lung perfusion显示文摘Lung transplant is the standard of care for patients with end-stage lung disease refractory to medical management. There is currently a critical organ shortage for lung transplantation with only 17% of offered organs being transplanted. Of those patients receiving a lung transplant, up to 25% will develop primary graft dysfunction, which is associated with an 8-fold increase in 30-d mortality. There are numerous mechanical lung assistance modalities that may be employed to help combat these challenges. We will discuss the use of mechanical lung assistance during lung transplantation, as a bridge to transplant, as a treatment for primary graft dysfunction, and finally as a means to remodel and evaluate organs deemed unsuitable for transplant, thus increasing the donor pool, improving survival to transplant, and improving overall patient survival. | Shaylyn C Bennett Eliza W Beal Curtis A Dumond Thomas Preston Jim Ralston Amy Pope-Harman Sylvester Black Don Hayes Jr Bryan A Whitson | 2015 | World Journal of Respirology2015，5，2： | 0 |
| 20 | Impact of transjugular intrahepatic porto-systemic shunt on post liver transplantation outcomes: Study based on the United Network for Organ Sharing database显示文摘AIM To determine the impact of transjugular intrahepatic porto-systemic shunt(TIPS) on post liver transplantation(LT) outcomes.METHODS Utilizing the United Network for Organ Sharing(UNOS) database, we compared patients who underwent LT from 2002 to 2013 who had underwent TIPS to those without TIPS for the management of ascites while on the LT waitlist. The impact of TIPS on 30-d mortality, length of stay(LOS), and need for re-LT were studied. For evaluation of mean differences between baseline characteristics for patients with and without TIPS, we used unpaired t-tests for continuous measures and χ~2 tests for categorical measures. We estimated the impact of TIPS on each of the outcome measures. Multivariate analyses were conducted on the study population to explore the effect of TIPS on 30-d mortality post-LT, need for re-LT and LOS. All covariates were included in logistic regression analysis.RESULTS We included adult patients(age ≥ 18 years) who underwent LT from May 2002 to September 2013. Only those undergoing TIPS after listing and before liver transplant were included in the TIPS group. We excluded patients with variceal bleeding within two weeks of listing for LT and those listed for acute liver failure or hepatocellular carcinoma. Of 114770 LT in the UNOS database, 32783(28.5%) met inclusion criteria. Of these 1366(4.2%) had TIPS between the time of listing and LT. We found that TIPS increased the days on waitlist(408 ± 553 d) as compared to those without TIPS(183 ± 330 d), P < 0.001. Multivariate analysis showed that TIPS had no effect on 30-d post LT mortality(OR = 1.26; 95%CI: 0.91-1.76) and re-LT(OR = 0.61; 95%CI: 0.36-1.05). Pre-transplant hepatic encephalopathy added 3.46 d(95%CI: 2.37-4.55, P < 0.001), followed by 2.16 d(95%CI: 0.92-3.38, P = 0.001) by TIPS to LOS. CONCLUSION TIPS did increase time on waitlist for LT. More importantly, TIPS was not associated with 30-d mortality and re-LT, but it did lengthen hospital LOS after transplantation. | Khalid Mumtaz Sherif Metwally Rohan M Modi Nishi Patel Dmitry Tumin Anthony J Michaels James Hanje Ashraf El-Hinnawi Don Hayes Jr Sylvester M Black | 2017 | World Journal of Hepatology2017，9，2： | 0 |
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