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| 1 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 2 | Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer’s disease by neurotoxin neutralization and immune recognition suppression显示文摘Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of neuroinflammation in the brain,leading to neurodegeneration in Alzheimer’s disease(AD).Blocking active recognition of microglia while removing neurotoxins holds promise for fundamentally alleviating neurotoxin-induced immune responses,but is very challenging.Herein,an engineered macrophage-biomimetic versatile nanoantidote(OT-Lipo@M)is developed for inflammation-targeted therapy against AD by neurotoxin neutralization and immune recognition suppression.Coating macrophage membranes can not only endow OT-Lipo@M with anti-phagocytic and inflammation-tropism capabilities to target inflammatory lesions in AD brain,but also efficiently reduce neurotoxin levels to prevent them from activating microglia.The loaded oxytocin(OT)can be slowly released to downregulate the expression of immune recognition site Toll-like receptor 4(TLR4)on microglia,inhibiting TLR4-mediated pro-inflammatory signalling cascade.Benefiting from this two-pronged immunosuppressive strategy,OT-Lipo@M exhibits outstanding therapeutic effects on ameliorating cognitive deficits,inhibiting neuronal apoptosis,and enhancing synaptic plasticity in AD mice,accompanied by the delayed hippocampal atrophy and brain microstructural disruption by in vivo 9.4T MR imaging.This work provides new insights into potential AD therapeutics targeting microglia-mediated neuroinflammation at the source. | Meng Cheng Caihua Ye Chunxiao Tian Dongju Zhao Haonan Li Zuhao Sun Yuyang Miao Qiang Zhang Junping Wang Yan Dou | 2023 | Bioactive Materials2023，，8： | 1 |
| 3 | A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer’s disease显示文摘Antioxidation and adjustable treatment strategies are critical for the effective treatment of Alzheimer’s disease(AD).Here,we design a dual-targeted Prussian blue nanoformulation(PTCN)that can cross the blood-brain barrier and target amyloid beta aggregates further exert antioxidant effects.An adjustable gradient dosing strategy with PTCN is used for the first time to design the preventive and therapeutic trials based on the severity of oxidative stress at different AD stages.The results show that PTCN could effectively ameliorate AD-related pathological processes,improve the cognitive decline,and rescue hippocampal atrophy of APP/PS1 mice in both preventive and therapeutic trials.Altogether,PTCN provided here is a successful combination of three traditional biomaterials with good biosafety,which has broad prospects for the early prevention,mild remission,and late treatment of AD,and is expected to be developed into personalized therapeutic drugs and healthcare products for clinical AD in the future. | Dongju Zhao Yuqing Tang Xinjun Suo Chaonan Zhang Yan Dou Jin Chang | 2021 | The Innovation2021，2，4： | 0 |
| 4 | Reliability of radiocarbon dating on various fractions of loess-soil sequence for Dadiwan section in the western Chinese Loess Plateau显示文摘黄土土壤序列标明日期的精确放射性碳在最后冻结成冰和 Holocene 期间在大陆人背景在环境、气候的变化的重建起一个必要作用。然而,我们土壤和黄土样品的各种各样的部分的放射性碳年龄的可靠性的知识仍然是不够的。这里,我们在场我们在放射性碳年龄的学习结果在西方的中国黄土高原从 loess-paleosol 节基于样品的体积有机物, humin 部分,和碳酸盐收集了。我们把这些观察与光学地刺激的光年龄和炭放射性碳年龄作比较评估这些部分的可靠性。我们观察到 humin 部分的放射性碳年龄离炭的那些很靠近并且与在试验性的错误以内的光学地刺激的光年龄一致。我们观察到在从那些的碳酸盐和炭和光学地刺激的光的体积有机物的放射性碳年龄的重要偏差变老,由于这些部分的冲淡可能在 pedogenetic 过程期间。我们的结果表明除了炭, humin 部分可以让步可靠 < 啜 class= “ a-plus-plus ” > 14 为中国黄土土壤顺序的 C 年龄。 | Zongli WANG Hui ZHAO Guanghui DONG Aifeng ZHOU Jianbao LIU Dongju ZHANG | 2014 | Frontiers of Earth Science2014，8，4： | 0 |
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