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| 1 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 2 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 3 | Quantitative estimation of the shrub canopy LAI from atmosphere-corrected HJ-1 CCD data in Mu Us Sandland显示文摘The leaf area index(LAI) is an important ecological parameter that characterizes the interface between vegetation canopy and the atmosphere.In addition,it is used by most process-oriented ecosystem models.This paper investigates the potential of HJ-1 CCD data combined with linear spectral unmixing and an inverted geometric-optical model for the retrieval of the shrub LAI in Wushen Banner of Inner Mongolia in the Mu Us Sandland.MODTRAN(Moderate Resolution Atmospheric Radiance and Transmittance Model) was used for atmospheric correction.Shrubland was extracted using the threshold of the normalized difference vegetation index,with which water bodies and farmland were separated,in combination with a vegetation map of the People's Republic of China(1:1000000).Using the geometric-optical model,we derive the per-pixel reflectance as a simple linear combination of two components,namely sunlit background and other.The fraction of sunlit background is related to the shrub LAI.With the support of HJ-1 CCD data,we employ linear spectral unmixing to obtain the fraction of sunlit background in an atmospherically corrected HJ image.In addition,we use the measured shrub canopy structural parameters for shrub communities to invert the geometric-optical model and retrieve the pixel-based shrub LAI.In total,18 sample plots collected in Wushen Banner of Inner Mongolia are used for validation.The results of the shrub LAI show good agreement with R2 of 0.817 and a root-mean-squared error of 0.173. | CHEN Wei1,2,CAO ChunXiang1,HE QiSheng1,2,GUO HuaDong3,ZHANG Hao1,2,LI RenQiang4,ZHENG Sheng1,2,XU Min1,2,GAO MengXu1,2,ZHAO Jian1,2,LI Sha1,NI XiLiang1,2,JIA HuiCong1,JI Wei1,TIAN Rong1,2,LIU Cheng1,2,ZHAO YuXing5 & LI JingLu6 1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Center for Earth Observation and Digital Earth,Chinese Academy of Sciences,Beijing 100190,China 4 China Key Laboratory of Ecological Network Observation and Modeling,Institute of Geographical Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing 100101,China 5 Ordos Forestry Sand Control Science Institute,Dongsheng 017000,China 6 Inner Mongolia Biomass Thermoelectricity Limited Company,Wushen 017300,China | 2010 | Science China Earth Sciences2010，53，S1： | 6 |
| 4 | Identity based signature scheme based on cubic residues显示文摘We propose a novel method to compute a cubic root of a cubic residue in Eisenstein ring.By applying our method,a new identity based signature scheme is proposed based on cubic residues.We formally prove that our scheme is secure against existential forgery on the adaptive chosen message and identity attacks assuming the hardness of factoring.Our scheme is the first identity based signature scheme based on cubic residues. | XING DongSheng CAO ZhenFu DONG XiaoLei | 2011 | Science China(Information Sciences)2011，54，10： | 4 |
| 5 | Enhanced ozonation degradation of atrazine in the presence of nano-ZnO: Performance, kinetics and effects显示文摘Enhanced ozonation degradation of atrazine(ATZ) with nano-ZnO(nZnO) as catalyst and the influences of the operational parameters have been investigated through semi-continuous experiments in this study. The results demonstrated that the combination of ozone(O_3) and nZnO showed an obvious synergetic effect and the ATZ degradation conformed to pseudo-first-order kinetics. An improvement of ATZ degradation efficiency by 41.8% and pseudo-first-order rate constant by more than a factor of four was obtained in the O_3/nZnO process after 5 min of reaction compared to O_3 alone. Meanwhile, the degradation efficiency of ATZ was gradually enhanced with increasing nZnO dosage and initial pH in the range from 3.0 to 8.0, and a higher amount of ATZ was degraded when the initial concentration of ATZ rose from 0.5 to 5 mg/L. Additionally, sulfate ion, chloride ion, nitrate ion and low concentrations of humic acid substances led to enhancement of the ATZ degradation. The notable decrease of ATZ removal efficiency observed in the presence of radical scavengers and the results of free radical tests indicated thatUOH is the dominant active radical species. The mechanism investigation demonstrated that the enhancement effect could be attributed to the introduction of nZnO,which could promote the utilization of O_3, enhance the formation of superoxide radical, and further accelerate the production of hydrogen peroxide and the generation of OH/O_2^-. | Xiangjuan Yuan Xuan Yan Haiming Xu Dongya Li Lei Sun Gang Cao Dongsheng Xia | 2017 | Journal of Environmental Sciences2017，29，11： | 4 |
| 6 | Roof filling control technology and application to mine roadway damage in small pit goaf显示文摘To recover coal resources that have been damaged by traditional mining methods and ensure stability of the lower roadway in a small pit goaf,the goaf area must be filled and reinforced.In this research,the 1202 working face of the Hanzui mine is considered as an example for classifying the roof of the mining tunnel under the small kiln destruction zone,the effect of the goaf on the roadway is determined based on the radio tunnel penetration method,a mechanical model to determine the roof filling control mechanism was established,and the duct foaming system and roof filling process were designed.The results show that the scope and degree of influence of the goaf on the mining lane are large,but safe tunneling can be ensured through the use of a steel shed and advanced grouting techniques.When the roof conditions are not similar,materials with different filling heights and filling strengths can be used to control the roof filling of the roadway.By combining field experience and laboratory tests,it was determined that a high-foaming material with a water-cement ratio of 1:0.6,a suitable high-foaming additive,and a water volume ratio of 1:30 is cost-efficient for filling and meets the filling strength requirements.Finally,the reliability of the proposed technology was verified by field experiments,which provide a reference for filling operations in similar mines. | Weiyi Cai Zechao Chang Dongsheng Zhang Xufeng Wang Wenhao Cao Yazhou Zhou | 2019 | International Journal of Mining Science and Technology2019，29，3： | 2 |
| 7 | Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study显示文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death. | Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 8 | Nonlin- ear dynamic modelling for MEMS components via the Cosserat rod dement approach显示文摘 | CAO Dengqing LIU Dongsheng WANG C H-T | 2005 | Journal of Micromechanics and Microengineering2005，15，6： | 1 |
| 9 | Particle speciation analysis of inorganic polymer flocculants:an examination by correlation spectroscopy显示文摘 | Wang Dongsheng Tang Hongxiao Cao Fucang | 2000 | Colloid and Surfaces2000，166，3： | 1 |
| 10 | Key wavelengths screening using competitive adaptive reweighted sampling method for multivariate calibration显示文摘 | Hongdong Li Yizeng Liang Qingsong Xu Dongsheng Cao | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 11 | Finite element formulation of slender structures with shear deformation based on the Cosserat theory显示文摘 | Dongsheng Liu D.Q. Cao Richard Rosing Charles H.-T. Wang Andrew Richardson | 2007 | International Journal of Solids and Structures2007，，24： | 1 |
| 12 | Three-dimensional nonlinear dynamics of slender structures: Cosserat rod element approach显示文摘 | D.Q. Cao Dongsheng Liu Charles H.-T. Wang | 2005 | International Journal of Solids and Structures2005，，3： | 1 |
| 13 | Particle speciation analysis of inorganic polymer flocculants: an examination by photon correlation spectroscopy 显示文摘 | Wang Dongsheng Hongxiao Tang Cao Fucang | 2000 | Colloids and Surfaces A2000，166，13： | 1 |
| 14 | Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network显示文摘Covalent ligands have attracted increasing attention due to their unique advantages,such as long residence time,high selectivity,and strong binding affinity.They also show promise for targets where previous efforts to identify noncovalent small molecule inhibitors have failed.However,our limited knowledge of covalent binding sites has hindered the discovery of novel ligands.Therefore,developing in silico methods to identify covalent binding sites is highly desirable.Here,we propose DeepCoSI,the first structure-based deep graph learning model to identify ligandable covalent sites in the protein.By integrating the characterization of the binding pocket and the interactions between each cysteine and the surrounding environment,DeepCoSI achieves state-of-the-art predictive performances.The validation on two external test sets which mimic the real application scenarios shows that DeepCosI has strong ability to distinguish ligandable sites from the others.Finally,we profiled the entire set of protein structures in the RCSB Protein Data Bank(PDB)with DeepCoSI to evaluate the ligandability of each cysteine for covalent ligand design,and made the predicted data publicly available on website. | Hongyan Du Dejun Jiang Junbo Gao Xujun Zhang Lingxiao Jiang Yundian Zeng Zhenxing Wu Chao Shen Lei Xu Dongsheng Cao Tingjun Hou Peichen Pan | 2022 | Research2022，，4： | 1 |
| 15 | A new strategy of outlier detection for QSAR/QSPR 显示文摘 | Cao Dongsheng Liang Yizeng Xu Qingsong | 2010 | Journal of Computational Chemistry2010，31，3： | 1 |
| 16 | Identification of terpenoids from Ephedra combining with accurate mass and in-silico retention indices显示文摘 | HE Min YAN Jun CAO Dongsheng | 2013 | Talanta2013，103，： | 1 |
| 17 | A new strategy of outlier detection for QSAR/QSPR 显示文摘 | CAO Dongsheng LIANG Yizeng XU Qingsong et d | 2010 | J Comput Chem2010，31，3： | 1 |
| 18 | Key wavelengths screening using competitive adaptive reweighted sampling method for multivariate calibration显示文摘 | Hongdong Li Yizeng Liang Qingsong Xu Dongsheng Cao | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 19 | Model-population analysis and its applications in chemical and biological modeling显示文摘 | Li Hongdong Liang Yizeng Cao Dongsheng | 2012 | Trends in Analytical Chemistry2012，，38： | 1 |
| 20 | A new strategy of outlier detection for QSAR/QSPR显示文摘 | CAO Dongsheng LIANG Yizeng XU Qingsong | 2010 | J Comput Chem2010，31，3： | 1 |
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