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| 1 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 2 | Shared Control of Highly Automated Vehicles Using Steer-By-Wire Systems显示文摘A shared control of highly automated Steer-by-Wire system is proposed for cooperative driving between the driver and vehicle in the face of driver's abnormal driving. A fault detection scheme is designed to detect the abnormal driving behaviour and transfer the control of the car to the automatic system designed based on a fault tolerant model predictive control(MPC) controller driving the vehicle along an optimal safe path.The proposed concept and control algorithm are tested in a number of scenarios representing intersection, lane change and different types of driver's abnormal behaviour. The simulation results show the feasibility and effectiveness of the proposed method. | Chao Huang Fazel Naghdy Haiping Du Hailong Huang | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 8 |
| 3 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 4 | Understandings and future challenges in soybean functional genomics and molecular breeding显示文摘Soybean(Glycine max)is a major source of plant protein and oil.Soybean breeding has benefited from advances in functional genomics.In particular,the release of soybean reference genomes has advanced our understanding of soybean adaptation to soil nutrient deficiencies,the molecular mechanism of symbiotic nitrogen(N)fixation,biotic and abiotic stress tolerance,and the roles of flowering time in regional adaptation,plant architecture,and seed yield and quality.Nevertheless,many challenges remain for soybean functional genomics and molecular breeding,mainly related to improving grain yield through high-density planting,maize-soybean intercropping,taking advantage of wild resources,utilization of heterosis,genomic prediction and selection breeding,and precise breeding through genome editing.This review summarizes the current progress in soybean functional genomics and directs future challenges for molecular breeding of soybean. | Haiping Du Chao Fang Yaru Li Fanjiang Kong Baohui Liu | 2023 | Journal of Integrative Plant Biology2023，65，2： | 2 |
| 5 | Efficacy of ICIs on patients with oncogene-driven non-small cell lung cancer:a retrospective study显示文摘Aim:The objective of our study was to assess the efficacy of immune checkpoint inhibitors(ICIs)on patients with non-small-cell lung cancer(NSCLC)harboring oncogenic alterations.Methods:We retrospectively enrolled patients with advanced non-squamous NSCLC who were treated with anti-PD-1-based monotherapy or combined immunotherapy.Major characteristics including PD-L1 expression,treatment,and survival were analyzed.Results:In total,309 non-squamous NSCLC patients with a median age of 61 years(range 20-88 years)including 70.9%male were retrospectively enrolled.The molecular alterations involved epidermal growth factor receptor(EGFR)(n=81),V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)(n=31),anaplastic lymphoma kinase(ALK)(n=1),human epidermal growth factor receptor 2(HER2)(n=12),V-raf murine sarcoma viral oncogene homolog(BRAF)(n=2),rearranged during transfection(n=4),and c-ros oncogene 1(ROS1)(n=3).In the EGFR subset,the ORR was 30.9%(n=81)and PFS was significantly shorter than WT group(median PFS:5.7 months vs.7.1 months;P=0.0061).In subgroup analyses,ICI combined therapy was significantly correlated with a longer PFS compared with ICI monotherapy(median PFS:7.7 months vs.4.7 months;P=0.0112).In KRAS patients,ORR was 51.6%(n=31).No significant difference was found in subgroup analyses.The ORR and PFS were 16.7%(n=12)and 28.6%(n=7),7.8 months and 9.0 months for HER2 and EGFR Exon20 insertion patients,respectively.Three ROS1 patients were enrolled with a PFS of 16.0,34.2,and 45.0 months individually,and one ALK patient with PFS of 4.4 months was identified.No response was found in two BRAF patients.Conclusion:ICI-based combination therapy can bring benefit to patients with EGFR-mutant NSCLC.ICI-based combination therapy could be considered for patients with ROS1 rearrangement,HER2 mutation and EGFR Exon20 insertion NSCLC. | Xiaojin Guo He Du Jiayu Li Menghang Yang Anweng Xiong Haiping Zhang Fengying Wu | 2022 | Cancer Drug Resistance2022，5，1： | 2 |
| 6 | Application of evolving Takagi- Sugeno fuzzy model to nonlinear system显示文摘 | Haiping Du Nong Zhang | 2008 | Applied Soft Computing2008，8，1： | 1 |
| 7 | H∞control of active vehicle suspensions with actuator time delay显示文摘 | Du Haiping Zhang Nong | 2007 | Journal of Sound and Vibration2007，301，： | 1 |
| 8 | Non-fragile H∞ vibration control for uncertain structural systems显示文摘 | Haiping Du James Lam Kam Yim Sze | 2004 | Journal of sound and Vibration (S0022-460X)2004，273，45： | 1 |
| 9 | Semi-active H∞ Control of Vehicle Suspension with Magneto-rheologi-cal Dampers显示文摘 | Du Haiping Sze K Y Lam J | 2005 | Journal of Sound and Vibration2005，28，35： | 1 |
| 10 | Application of evolving Takagi-Sugeno fuzzy model to nonlinear system identification显示文摘 | Du Haiping Zhang Nong | 2008 | Applied Soft Computing2008，8，1： | 1 |
| 11 | Semi-active H∞control of vehicle suspension with magneto-rheological dampers显示文摘 | Du Haiping Kam Yim Sze James Lam | 2005 | Journal of Sound and Vibration2005，283，35： | 1 |
| 12 | Semi-active H∞ control of vehicle suspension with magneto-theological dampers显示文摘 | Haiping Du Kam Yim Sze James Lam | 2005 | Journal of Sound and Vibration2005，283，35： | 1 |
| 13 | Application of evolving Takagi-Sugeno fuzzy model to nonlinear system identification显示文摘 | Du Haiping Zhang Nong | 2008 | Applied SoftComputing2008，8，1： | 1 |
| 14 | An Adaptive Neuro Fuzzy Hybrid Control Strategy for a Semiactive Suspension with Magneto Rheological Damper显示文摘 | Pipit Wahyu Nugroho Weihua Li Haiping Du Gursel Alici Jian Yang Jeong-Hoi Koo | 2014 | Advances in Mechanical Engineering2014，，： | 1 |
| 15 | Semi-active Formula Not Shown Control of Vehicle Suspension with Magneto-rheologlcal dampers 显示文摘 | DU Haiping YIM Sze kam LAM James | 2005 | Journal of Sound and Vibration2005，283，35： | 1 |
| 16 | Application of evolving Takagi-Sugeno fuzzy model to nonlinear system identi- fication显示文摘 | Du Haiping Zhang Nong | 2008 | Applied Soft Computing2008，8，1： | 1 |
| 17 | Development and simulation evaluation of a magnetorheological elastomer isolator for seat vibration control显示文摘 | Li Weibua Zhang Xianzhou Du Haiping | 2012 | Journal of Intelligent Material Systems and Structures2012，23，9： | 1 |
| 18 | Modelling of a Magneto- rheological Damper by Evolving Radial Basis Function Networks 显示文摘 | Du Haiping Lain James Zhang Nong | 2006 | Engineering Applications of Artificial Intelligence2006，19，8： | 1 |
| 19 | Application of evolving Taka- gi-Sugeno fuzzy model to nonlinear system identifica- tion显示文摘 | Du Haiping Zhang Nong | 2008 | Applied Soft Computing2008，8，： | 1 |
| 20 | Experimental study and modeling of a novel magnetorheologieal elastomer isolator 显示文摘 | YANG Jian DU Haiping LI Weihua | 2013 | Smart Materi- als and Structures2013，22，11： | 1 |
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