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| 1 | A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh显示文摘Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which has the dominant Aft locus combined with the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the fruit skin. Here, we report that Aft encodes a functional anthocyanin activator named SlAN2-like, while atv encodes a nonfunctional version of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light, and the functional SlAN2-like can activate the expression of both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator in the activation of anthocyanin biosynthesis. We further showed that cultivated tomatoes contain nonfunctional alleles of SlAN2-like and therefore fail to produce anthocyanins. Consistently, expression of a functional SlAN2-like gene driven by the fruit-specific promoter in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high-level accumulation of anthocyanins in both the peel and flesh. Taken together, our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators. | Chuanlong Sun Lei Deng Minmin Du Jiuhai Zhao Qian Chen Tingting Huang Hongling Jiang Chang-Bao Li Chuanyou Li | 2020 | Molecular Plant2020，13，1： | 17 |
| 2 | Efficient generation of pink-fruited tomatoes using CRISPR/Cas9 system显示文摘Tomato(Solanum lycopersicum)is the leading vegetable crop worldwide and an essential component of a healthy diet(Lin et al.,2014;Du et al.,2017).Fruit color is regarded as one of the most important commercial traits in tomato(The Tomato Genome Consortium,2012).Consumers in different regions have different color preferences.For example,European and | Lei Deng Hang Wang Chuanlong Sun Qian Li Hongling Jiang Minmin Du Chang-Bao Li Chuanyou Li | 2018 | Journal of Genetics and Genomics2018，45，1： | 13 |
| 3 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 4 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis Thrombosis and Vascular Biology2009，，2： | 2 |
| 5 | A Cooperative Network Intrusion Detection Based on Fuzzy SVMs显示文摘 | Teng Shaohua Du Hongle Wu Naiqi | 2010 | Journal of Network2010，5，4： | 1 |
| 6 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，2： | 1 |
| 7 | A Cooperative Net- work Intrusion Detection Based on Fuzzy SVMs显示文摘 | Teng Shaohua Du Hongle Wu Naiqi | 2010 | Journal of Networks2010，5，4： | 1 |
| 8 | A cooperative network intrusion detection based on fuzzy SVMs显示文摘 | Teng Shaohua Du Hongle Wu Naiqi | 2010 | Journal of Network2010，5，4： | 1 |
| 9 | Endothelin typeA receptor(ETA)expression is regulated by HOXA10 in humanendometrial stromal cells显示文摘 | Penna IA Hongling DU Kallen AN | 2010 | Reprod Sci2010，17，5： | 1 |
| 10 | Poisoning effect of some nitrogen compounds on nano - sized nickel catalysts in p-nitrophenol hydrogenation 显示文摘 | DU Yan CHEN Hongling CHEN Rizhi | 2006 | Chem Eng J2006，125，： | 1 |
| 11 | Synthesis of p- aminophenol from p - nitrophenol over nano- sized nickel catalysts 显示文摘 | Du Yan Chen Hongling Chen Rizhi | 2004 | Appl Cat A: General2004，277，： | 1 |
| 12 | Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis显示文摘 | Wolff EF Wolff AB Hongling DU | 2007 | Reprod Sci2007，14，6： | 1 |
| 13 | Demonstration of multipotent stem cells in the adult human endometrium by in vitro chondrogenesis显示文摘 | Wolff EF Wolff AB Hongling Du | 2007 | Reprod Sci2007，14，6： | 1 |
| 14 | Isehemia/reperfusion injury promotes and granulocyte - colony stimulating factor inhibits migration of bone marrow - derived stem cells to endometrium 显示文摘 | DU Hongling NAQVI H TAYLOR H S | 2012 | Stem Cells and Development2012，21，18： | 1 |
| 15 | A cooperative net- work intrusion detection based on fuzzy SVMs 显示文摘 | Teng Shaohua Du Hongle Wu Naiqi | 2010 | Journal of Networks2010，5，4： | 1 |
| 16 | Bone Marrow - Derived stem cell (BMDSC) transplantation improves fertility in a murine model of ashennan~ syndrome 显示文摘 | ALAWADHI F DU Hongling CAKMAK H | 2014 | PLOS One2014，9，96： | 1 |
| 17 | Pluripotent stem cell-derived CD 19-CAR iT cells effectively eradicate B-cell lymphoma in vivo显示文摘Chimeric antigen receptor T cell(CAR-T)therapy is one of the most promising approaches in cancer treatment.1 However,the limited availability of patient-derived T cells narrows its universal applicability.Thus,it is necessary to invent new methods to obtain alternative T-cell sources.Pluripotent stem cells(PSCs),which have unlimited culture potential and are amenable to gene editing,are ideal for generating induced T(iT)cells. | Cui Lv Shoubing Chen Fangxiao Hu Dehao Huang Tongjie Wang Juan Du Jinyong Wang Hongling Wu | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 18 | Robust,flame-retardant and colorful superamphiphobic aramid fabrics for extreme conditions显示文摘High-performance superamphiphobic fabrics are very useful in special fields,such as firefighting,rescue,and polar sports.The complicated preparation process,easily damaged surface structure,and high cost drastically limit their commercial application.In this work,we utilized a simple,low-cost superamphiphobic coating to prepare a superamphiphobic aramid fabric(SAF).The excellent repellency to acid/alkali solutions and low boiling point organic solvents has been demonstrated with the contact angle of>150°and>130°,respectively.Additionally,the original color of the fabric can also be maintained,accompanied by superior flame retardancy,strength and comfort with thermal degradation of 361℃.More importantly,SAF displayed excellent durability via 50 standard machine washes,100-min of ultrasonic washing,10-min of UV irradiation,120-min of high-temperature heating,5000 cycles of abrasion,and destructive abrasion by sharp metal.All the results showed the superior performance of our SAF in protective fabrics under extreme environmental conditions. | LIU Xiang CHEN JunLi SHAO QingQing CAO JiQiang DU ZhaoQun LIU HongLing YU WeiDong | 2021 | Science China(Technological Sciences)2021，64，8： | 0 |
| 19 | T cell regeneration: an update on progress and challenges显示文摘T cells play essential roles in antitumor therapy.Via gene engineering technique to enhance tumor-antigen specificity,patient peripheral blood-derived T cells(PBT)show encouraging clinical outcomes in treating certain blood malignancies.However,the high costs,functionality exhaustion,and disease-condition-dependent availability of PBT prompt the attempts of exploring alternative T cell sources.Theoretically,induced T cells from pluripotent stem cells(PSC)are ideal candidates that integrate plenty of advantages that primary T cells lack,including unlimited off-the-shelf cell source and precision gene editing feasibility.However,researchers are still struggling with developing a straightforward protocol to induce functional and immunocompetent human T cells from PSC.Based on stromal cell-expressing or biomaterial-presenting Notch ligands DLL1 or DLL4,natural and induced blood progenitors can differentiate further toward T lineage commitment.However,none of the reported T induction protocols has yet translated into any clinical application,signaling the existence of numerous technical barriers for regenerating T cells functionally matching their natural PBT counterparts.Alternatively,new approaches have been developed to repopulate induced T lymphopoiesis via in vivo reprogramming or transplanting induced T cell precursors.Here,we review the most recent progress in the T cell regeneration field,and the remaining challenges dragging their clinical applications. | Rongqun Guo Hongling Wu Juan Du Jinyong Wang | 2020 | Blood Science2020，2，1： | 0 |
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