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| 1 | Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease显示文摘Intermedin(IMD)or adrenomedullin 2 is a novel peptide related to the calcitonin gene-related peptide(CGRP)family.Via calcitonin receptor-like receptor/receptor activity modifying proteins,the common receptor complexes of CGRP,IMD exerts a wide range of biological effects,especially regulation of cardiovascular homeostasis.Proteolytic processing of a larger IMD precursor yields a series of biologically active C-terminal fragments,IMD1–53,IMD1–47 and IMD8–47.IMD and its receptors are present in the cardiovascular system,and IMD is present at low levels in plasma.In the cardiovascular system,IMD has multiple functions such as regulation of blood pressure and cardiac function,pro-angiogenesis,endothelial barrier function protection,anti-oxidative stress,and anti-endoplasmic reticulum stress.IMD participates widely in the pathogenesis of atherosclerosis,hypertension,pulmonary arterial hypertension and vascular calcification.It is a vascular regulatory factor of homeostasis and a vital endogenous protective factor against vascular diseases. | NI XianQiang ZHANG JinSheng TANG ChaoShu QI YongFen | 2014 | Science China(Life Sciences)2014，57，8： | 14 |
| 2 | Interaction between en- dogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension显示文摘The aim of the study was to investigate the in-teraction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmo-nary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hy-pertension developed after 2-week hypoxia, while the con-centration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endoge-nous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homoge-nates and the expression of HO-1 in intrapulmonary artery smooth muscle cells increased markedly with hypoxic pul-monary hypertension. L-NAME worsened pulmonary hy-pertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P < 0.01). The results of this study sug-gested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension. | SHI Yun, DU Junbao, GUO Zhiliang, ZENG Chaomei & TANG Chaoshu Department of Pediatrics, the First Hospital, Peking University, Beijing 100034, China Correspondence should be addressed to Du Junbao (e-mail: junbaodu@ ht.rol.cn) | 2003 | Chinese Science Bulletin2003，48，1： | 8 |
| 3 | Autonomic Nervous Function in Vasovagal Syncope of Children and Adolescents显示文摘Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion, accompanied by loss of muscle tone and failure to maintain an active position. Vasovagal syncope (VVS) is the most common presentation of syncope, and its diagnostic criteria include:(1) absence of any other evident etiology for syncope or presyncope,(2) positive response to head-up tilt test with evident vasovagal reaction (hypotension and/or bradycardia), and (3) no concomitant chronic or acute disease [1, 2]. The onset of VVS peaks initially in childhood and adolescence, and accounts for 60%–70% of all syncopal cases. Clinicians pay great attention to syncope among children and adolescents, due to its high prevalence and its impact on patients’ quality of life. Affected individuals often experience mental stress, economic burdens, and accidental bodily injuries related to syncope [2]. While the pathogenesis of VVS is not fully understood, autonomic nervous dysfunction has been identified as a contributing mechanism. The examination of autonomic nervous function can provide important information about patients with syncope. | Chunyan Tao Chaoshu Tang Selena Chen Hongfang Jin Junbao Du | 2019 | Neuroscience Bulletin2019，35，5： | 6 |
| 4 | Immune regulation of hydrogen sulfide in children with acute lymphoblastic leukemia显示文摘 | Du Shuxu Jia Yongrui Tang Hong Sun Yangling Wu Wanshui Sun Liming Du Junbao Geng Bin Tang Chaoshu Jin Hongfang | 2014 | Chinese Medical Journal2014，，21： | 5 |
| 5 | Space-time clutter model for airborne bistatic radar with non-Gaussian statistics显示文摘To validate the potential space-time adaptive processing (STAP) algorithms for airborne bistatic radar clutter suppression under nonstationary and non-Gaussian clutter environments, a statistically non-Gaussian, space- time clutter model in varying bistatic geometrical scenarios is presented. The inclusive effects of the model contain the range dependency of bistatic clutter spectrum and clutter power variation in range-angle cells. To capture them, a new approach to coordinate system conversion is initiated into formulating bistatic geometrical model, and the bistatic non-Gaussian amplitude clutter representation method based on a compound model is introduced. The veracity of the geometrical model is validated by using the bistatic configuration parameters of multi-channel airborne radar measurement (MCARM) experiment. And simulation results manifest that the proposed model can accurately shape the space-time clutter spectrum tied up with specific airborne bistatic radar scenario and can characterize the heterogeneity of clutter amplitude distribution in practical clutter environments. | Duan Rui Wang Xuegang Jiang Chaoshu Chen Zhuming | 2009 | Journal of Systems Engineering and Electronics2009，20，2： | 4 |
| 6 | Catalytic performances of heteropoly compounds supported on dealuminated ultra-stable Y zeolite for liquid-phase esterification显示文摘A series of catalysts of 12-Phosphotungstic acid (PW) and its cesium salts immobilizedon dealuminated ultra-stable Y zeolite (DUSY) were prepared. Their specific surface area and acidstrength were characterized, and their catalytic activity, selectivity and stability were evaluated in theliquid-phase esterification of acetic acid with n-butanol. It was found that the catalytic activity could beimproved remarkably by introducing PW onto dealuminated USY (from 49.5% to 86.4%). Howeverthis obvious promotion effect of PW could not be observed on USY supported PW catalyst, whichshowed rather low conversion of less than 25.0%. The supported cesium salt of PW on DUSY catalysgave a very high conversion of n-butanol of 94.6% and the 100% selectivity for n-butyl acetate. Thecatalytic stability test revealed that after 5 reaction cycles, the catalytic activity over PW/DUSY drastically dropped to 47.6%, by contrast, the PW cesium salt/DUSY still showed a high conversion o81.6%. The leaching test for catalysts in water showed that the decrease of activity was closely associated with the solubility of the active heteropoly components on supports into the polar solvent, whichindicates that the catalytic deactivation was mainly due to the lose of the heteropoly species in thereaction medium. The high catalytic stability of the supported cesium salts of PW is suggested to bederived from the water-tolerance of cesium salts of PW in the polar reaction system. | ZHANG Fumin WANG Jun YUAN Chaoshu REN Xiaoqian | 2006 | Science China Chemistry2006，49，2： | 4 |
| 7 | The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells显示文摘 | Junbao Du Yan Hui Yiufai Cheung Geng Bin Hongfeng Jiang Xiaobo Chen Chaoshu Tang | 2004 | Heart and Vessels2004，，2： | 3 |
| 8 | Changes of atrial natriuretic peptide and antidiuretic hormone in children with postural tachycardia syndrome and orthostatic hypertension: a case control study显示文摘 | Zhao Juan Yang Jinyan Du Shuxu Tang Chaoshu Du Junbao Jin Hongfang | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 9 | Endoplasmic reticulum stress-mediated apoptosis is activated in vascular calcification显示文摘 | Xiaohui Duan Yebo Zhou Xu Teng Chaoshu Tang Yongfen Qi | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 3 |
| 10 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis Thrombosis and Vascular Biology2009，，2： | 2 |
| 11 | Hydrogen sulfide system in the pathogenesis of renovascular hypertension in rats显示文摘Objective To investigate the role of hydrogen sulfide (H2S) synthases / H2S pathway in the pathogenesis of renovascular hypertension. Methods Wistar rats were subdivided into 4 groups: (1) 2-kidney, 1-clip (2K-1C group, n=7), (2) control (n=7), (3) sham (n=7), and (4) 2K-1C plus sodium hydrosulfide (NaHS) (NaHS-treated group, n=7). The systolic blood pressure (SBP) was measured by a tail-cuff method using a pulse transducer once a week. Four weeks later, all rats were killed and the concentration of plasma hydrogen sulfide (H2S), the activity of the H2S synthases in the kidneys on both sides, the plasma angiotensin Ⅱconcentration, and the left-to-whole heart weight ratio were measured. Results The SBP was significantly increased in the 2K-1C group (185.4±14.0mmHg) comparing with those in the sham group ( 112.9±6.5mmHg, , or the NaHS-treated group(134.8±9.5mmHg) (both P<0.01). At 4 weeks, the angiotensin Ⅱ concentration in the plasma was increased in the 2K-1C and NaHS-treated group, comparing with the control and the sham group (306.92±7.03 pg/ml and 240.73±13.22 pg/ml vs 122.6±25.49 pg/ml and 125.95±10.55 pg/ml, respectively, both P<0.05). The plasma H2S concentration and the activity of H2S synthases in the left kidney were decreased in the 2K-1C group comparing with those in the sham and the control groups. There was no difference of the activity of the H2S synthases in the right kidneys among the 4 groups. The left-to-whole heart weight ratio was increased in the 2K-1C and the NaHS-treated group camparing with that in the sham and natural control groups. Conclusions Dysfunction of the H2S synthases/H2S pathway was involved in the 2K-1C-induced renovascular hypertension in rat. Exogenous administration of H2S donor can attenuate the development of hypertension. These findings suggest that the H2S synthases/H2S pathway participates in the pathogenesis of renovascular hypertension. | Youqin Cheng Daiqin Wu Guang Yang Xiaoying Li Dayan Huang Bin Geng Chaoshu Tang | 2008 | Journal of Geriatric Cardiology2008，5，2： | 2 |
| 12 | H 2 S generated by heart in rat and its effects on cardiac function显示文摘 | Bin Geng Jinghui Yang Yongfen Qi Jing Zhao Yongzheng Pang Junbao Du Chaoshu Tang | 2003 | Biochemical and Biophysical Research Communications2003，，2： | 2 |
| 13 | The effects of salinity on the survival, growth and haemolymph osmolality of early juvenile blue swimmer crabs, Portunus pelagicus显示文摘 | Nicholas Romano Chaoshu Zeng | 2006 | Aquaculture2006，，1： | 2 |
| 14 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 15 | Luminescence and energy transfer processes in Lu 2 SiO 5 :Ce 3+ scintillator显示文摘 | Bo Liu Chaoshu Shi Min Yin Yibin Fu Guobin Zhang Guohao Ren | 2005 | Journal of Luminescence2005，，2： | 1 |
| 16 | Hydrogen sulfide as a new endogenous gaseous transmitter in the cardiovascular system显示文摘 | Tang Chaoshu Li Xiaohong Du Junbao | 2006 | Current Vascular Pharmacology2006，4，： | 1 |
| 17 | Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice显示文摘 | Yanfei Wang Xia Zhao Hongfang Jin Hongling Wei Wei Li Dingfang Bu Xiuying Tang Yali Ren Chaoshu Tang Junbao Du | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，2： | 1 |
| 18 | Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells显示文摘 | Juxiang Li Sanbao Chai Chaoshu Tang Junbao Du | 2003 | Life Sciences2003，，4： | 1 |
| 19 | Impact of l -arginine on hydrogen sulfide/cystathionine-γ-lyase pathway in rats with high blood flow-induced pulmonary hypertension显示文摘 | Wang Yanfei Shi Lin Du Junbao Tang Chaoshu | 2006 | Biochemical and Biophysical Research Communications2006，，2： | 1 |
| 20 | Influence of Sb Doping on the Luminescent Properties of PbWO4 Single Crystals显示文摘 | Chen Yonghu Shi Chaoshu Hu Guanqin | 2000 | Journal of Applied Physics2000，87，3： | 1 |
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