|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Design of OFF/ON fluorescent thiol probes based on coumarin fluorophore显示文摘This paper presents a series of first-and second-generation click-modified coumarin-based fluorescent probes for thiols.These molecules demonstrate high turn-on fluorescent response and good selectivity towards aromatic thiols over other relevant reactive sulfur species,reactive oxygen species and common nucleophiles.Moreover,probe 1a can detect thiols in the reduced rabbit plasma sample.Therefore,this approach provides a particularly impressive tool for detecting thiol in biological systems. | SUN Wei LI Jing LI WenHua SU LiJuan DU LuPei LI MinYong | 2012 | Science China Chemistry2012，55，9： | 2 |
| 2 | Aptamer-based carbohy- drate recognition 显示文摘 | Sun Wei Du Lupei Li Minyong | 2010 | Curr Pharm Des2010，16，20： | 1 |
| 3 | Advances and Perspectives in Cell-Specific Aptamers显示文摘 | Wei Sun Lupei Du Minyong Li | 2011 | Current Pharmaceutical Design2011，，1： | 1 |
| 4 | Update on the slow delayed recrified potassium current(IKS):role in modulating cardiac function显示文摘 | Zhenzhen Liu Lupei Du Mingyong Li | 2012 | Bentham Journal2012，19，9： | 1 |
| 5 | Bifunctional fluorescent probes for hydrogen peroxide and diols based on a 1,8-naphthalimide fluorophore显示文摘This report discloses a series of naphthalimide-based bifunctional fluorescent probes for hydrogen peroxide and diols.As a result,these molecules not only demonstrated high turn-on fluorescent response and good selectivity towards hydrogen peroxide over other relevant reactive oxygen species,but also displayed different responses to diols.Therefore,these fluorescent probes could be served as sensitive,selective and practical chemosensors for both hydrogen peroxide and diols under physiologicallike conditions. | SUN Wei MA Zhao LI Jing LI WenHua DU LuPei LI MinYong | 2013 | Science China Chemistry2013，56，10： | 0 |
| 6 | Incorporating kernelized multi-omics data improves the accuracy of genomic prediction显示文摘Background:Genomic selection(GS)has revolutionized animal and plant breeding after the first implementation via early selection before measuring phenotypes.Besides genome,transcriptome and metabolome information are increasingly considered new sources for GS.Difficulties in building the model with multi-omics data for GS and the limit of specimen availability have both delayed the progress of investigating multi-omics.Results:We utilized the Cosine kernel to map genomic and transcriptomic data as n×n symmetric matrix(G matrix and T matrix),combined with the best linear unbiased prediction(BLUP)for GS.Here,we defined five kernel-based prediction models:genomic BLUP(GBLUP),transcriptome-BLUP(TBLUP),multi-omics BLUP(MBLUP,M=ratio×G+(1-ratio)×T),multi-omics single-step BLUP(mss BLUP),and weighted multi-omics single-step BLUP(wmss BLUP)to integrate transcribed individuals and genotyped resource population.The predictive accuracy evaluations in four traits of the Chinese Simmental beef cattle population showed that(1)MBLUP was far preferred to GBLUP(ratio=1.0),(2)the prediction accuracy of wmss BLUP and mss BLUP had 4.18%and 3.37%average improvement over GBLUP,(3)We also found the accuracy of wmss BLUP increased with the growing proportion of transcribed cattle in the whole resource population.Conclusions:We concluded that the inclusion of transcriptome data in GS had the potential to improve accuracy.Moreover,wmss BLUP is accepted to be a promising alternative for the present situation in which plenty of individuals are genotyped when fewer are transcribed. | Mang Liang Bingxing An Tianpeng Chang Tianyu Deng Lili Du Keanning Li Sheng Cao Yueying Du Lingyang Xu Lupei Zhang Xue Gao Junya Li Huijiang Gao | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 7 | Visualization of α_1-adrenergic receptors with phenylpiperazine-based fluorescent probes显示文摘Several novel fluorescent probes targeting α_1-adrenergic receptors were well designed and synthesized by conjugating phenylpiperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed suitable fluorescence property, high receptor affinity, and low cytotoxicity. Moreover, the cell imaging results displayed that these probes can be effective tools for the real-time detection of ligand-receptor interactions, as well as the visualization and location of α_1-adrenergic receptors in living cells. | Yuxing Lin Wenhua Li Qinying Yu Xinyang Zhou Wei Zhang Lupei Du Minyong Li | 2016 | Science China Chemistry2016，59，5： | 0 |
| 8 | A specific and selective chemiluminescent probe for Pd^(2+) detection显示文摘As an important transition metal catalyst, palladium is extensively used in many areas including electronics industry, petroleum industry, automobile industry and fine chemicals engineering. However,it brings harm to the environment as well as people's health. Herein, we managed to introduce a butynyl group to 1,2-dioxetane developing a reaction-based chemiluminescent probe as well as an imaging approach for monitoring palladium(II). Exhibiting enhanced total flux in Pd2+enriched areas, palladium chemiluminescent probe(PCL) may afford potential utility for detecting Pd2+in vitro, in cellulo and in vivo. | Yuqi Gao Yuxing Lin Tingting Liu Xiaomeng Zhang Feng Xu Pan Liu Lupei Du Minyong Li | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 9 | Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives显示文摘In recent years,various methods for detecting exogenous and endogenous hypochlorite have been studied,considering its essential role as a biomolecule.However,the existing technologies still pose obstacles such as their invasiveness,high costs,and complicated operation.In the current study,we developed a glow-type chemiluminescent probe,hypochlorite chemiluminescence probe(HCCL)-1,based on the scaffold of Schaap's 1,2-dioxetane luminophores.To better explore the physiological and pathological functions of hypochlorite,we modified the luminophore scaffold of HCCL-1 to develop several probes,including HCCL-2,HCCL-3,and HCCL-4,which amplify the response signal of hypochlorite.By comparing the luminescent intensities of the four probes using the IVIS®system,we determined that HCCL-2 with a limit of detection of 0.166 mM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo. | Yingai Sun Yuqi Gao Chunchao Tang Gaopan Dong Pei Zhao Dunquan Peng Tiantian Wang Lupei Du Minyong Li | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 0 |
| 10 | Fluorescence triggered by ligand-protein hydrophobic interaction显示文摘Hydrophobic fluorescence:Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore.The design strategy described in this report generalized the environment sensitivity turn-on mechanism to recognize a specific protein,which provides a robust breakthrough for interchanging fluorescence in conventional small-molecule fluorescent imaging. | LIU ZhenZhen DU LuPei LI MinYong | 2013 | Science China Chemistry2013，56，11： | 0 |
| 11 | Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning显示文摘Head and neck squamous cell carcinoma(HNSCC) is one of the most common human cancers;however, its outcome of pharmacotherapy is always very limited. Herein, we performed a batch query in the connectivity map(cMap) based on bioinformatics, queried out 35 compounds with therapeutic potential, and screened out parbendazole as a most promising compound, which had an excellent inhibitory effect on the proliferation of HNSCC cell lines. In addition, tubulin was identified as a primary target of parbendazole, and the direct binding between them was further verified. Parbendazole was further proved as an effective tubulin polymerization inhibitor, which can block the cell cycle, cause apoptosis and prevent cell migration, and it exhibited reasonable therapeutic effect and low toxicity in the in vivo and in vitro anti-tumor evaluation. Our study repositioned an anthelmintic parbendazole to treat HNSCC, which revealed a therapeutic utility and provided a new treatment option for human cancers. | Dong Liang Chen Yu Zhao Ma Xingye Yang Zhenzhen Li Xuhui Dong Xiaojun Qin Lupei Du Minyong Li | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员