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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 3 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 4 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 5 | Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress显示文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg 1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg 1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP (C/EBP homologous protein), and attenuated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myocardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis. | WANG JianFei WANG Yin SHAN ShiFu HU TianTian CHEN HuYan TIAN Jing REN AnJing ZHOU Xu YUAN WenJun LIN Li | 2012 | Science China(Life Sciences)2012，55，4： | 11 |
| 6 | Identification of potential cross-protective epitope between a new type of coronavirus(2019-nCoV)and severe acute respiratory syndrome virus显示文摘Recently,a new type of unknown virus causing severe acute res-piratory infection was reported in Wuhan city,Hubei province,China(WHO,2020b).Infection of this virus was first reported in December 2019,and origin of the virus was traced back to a large seafood/wide animal market in Wuhan city.The serious clinical symptoms of the viral infection,including fever,dry cough,dys-pnea,and pneumonia,may result in progressive respiratory failure and even death.Moreover,the quick spread of the virus has caused an epidemic in China,as well as infection cases worldwide.The whole-genome sequence of Wuhan new virus(WH-Human_.1)was first released on January 10,2020(Zhang,2020),followed by additional ones released in Global Initiative on Sharing All Influ-enza Data(GISAID)(Shu and McCauley,2017).Later,this new virus was determined and announced as a new type of coronavirus(CoV;2019-nCoV)by the World Health Organization(WHO,2020a). | Tianyi Qiu Tiantian Mao Yuan Wang Mengdi Zhou Jingxuan Qiu Jianwei Wang Jianqing Xu Zhiwei Cao | 2020 | Journal of Genetics and Genomics2020，47，2： | 11 |
| 7 | Spatio-temporal Pattern of Net Primary Productivity in Hengduan Mountains area, China: Impacts of Climate Change and Human Activities显示文摘Net primary productivity(NPP), a metric used to define and identify changes in plant communities, is greatly affected by climate change, human activities and other factors. Here, we used the Carnegie-Ames-Stanford Approach(CASA) model to estimate the NPP of plant communities in Hengduan Mountains area of China, and to explore the relationship between NPP and altitude in this region. We examined the mechanisms underlying vegetation growth responses to climate change and quantitatively assessed the effects of ecological protection measures by partitioning the contributions of climate change and human activities to NPP changes. The results demonstrated that: 1) the average total and annual NPP values over the years were 209.15 Tg C and 468.06 g C/(m2·yr), respectively. Their trend increasingly fluctuated, with spatial distribution strongly linked to altitude(i.e., lower and higher NPP in high altitude and low altitude areas, respectively) and 2400 m represented the marginal altitude for vegetation differentiation; 2) areas where climate was the main factor affecting NPP accounted for 18.2% of the total research area, whereas human activities were the primary factor influencing NPP in 81.8% of the total research area, which indicated that human activity was the main force driving changes in NPP. Areas where climatic factors(i.e., temperature and precipitation) were the main driving factors occupied 13.6%(temperature) and 6.0%(precipitation) of the total research area, respectively. Therefore, the effect of temperature on NPP changes was stronger than that of precipitation; and 3) the majority of NPP residuals from 2001 to 2014 were positive, with human activities playing an active role in determining regional vegetation growth, possibly due to the return of farmland back to forest and natural forest protection. However, this positive trend is decreasing. This clearly shows the periodical nature of ecological projects and a lack of long-term effectiveness. | CHEN Tiantian PENG Li LIU Shaoquan WANG Qiang | 2017 | Chinese Geographical Science2017，27，6： | 10 |
| 8 | Numerical and Experimental Study on Ventilation Panel Models in a Subway Passenger Compartment显示文摘The internal flow field study of car compartments is an important step in railroad vehicle design and optimization. The flow field profile has a significant impact on the temperature distribution and passenger comfort level. Experimental studies on flow field can yield accurate results but carry a high time and computational cost. In contrast, the numerical simulation method can yield an internal flow field profile in less time than an experimental study. This study aims to improve the computational efficiency of numerical simulation by adapting two simplified models—the porous media model and the porous jump face model—to study the internal flow field of a railroad car compartment. The results provided by both simplified models are compared with the original numerical simulation model and with experimental data. Based on the results, the porous media model has a better agreement with the original model and with the experimental results. The flow field parameters (temperature and velocity) of the porous media model have relatively small numerical errors, with a maximum numerical error of 4.7%. The difference between the numerical results of the original model and those of the porous media model is less than 1%. By replacing the original numerical simulation model with the porous media model, the flow field of subway car compartments can be calculated with a reduction of about 25% in computing resources, while maintaining good accuracy. | Yu Tao Mingzhi Yang Bosen Qian Fan Wu Tiantian Wang | 2019 | Engineering2019，5，2： | 9 |
| 9 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 10 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 11 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 12 | Perovskite light-emitting/detecting bifunctional fibres for wearable LiFi communication显示文摘Light fidelity(LiFi),which is emerging as a compelling technology paradigm shifting the common means of highcapacity wireless communication technologies,requires wearable and full-duplex compact design because of its great significance in smart wearables as well as the‘Internet of Things’.However,the construction of the key component of wearable full-duplex LiFi,light-emitting/detecting bifunctional fibres,is still challenging because of the conflicting process between carrier separation and recombination,as well as the highly dynamic film-forming process.Here,we demonstrate light-emitting/detecting bifunctional fibres enabled by perovskite QDs with hybrid components.The hybrid perovskite inks endow fibres with super-smooth QD films.This,combined with the small exciton binding energy and high carrier mobility of perovskite QDs,enables successful integration of electroluminescence and photodetection into monofilaments.The bifunctional fibres possess the narrowest electroluminescence full width at half maximum of ~19 nm and,more importantly,the capability for simultaneously transmitting and receiving information.The successful fabrication of narrow emission full-duplex LiFi fibres paves the way for the fabrication and integration of low crosstalk interoperable smart wearables. | Qingsong Shan Changting Wei Yan Jiang Jizhong Song Yousheng Zou Leimeng Xu Tao Fang Tiantian Wang Yuhui Dong Jiaxin Liu Boning Han Fengjuan Zhang Jiawei Chen Yongjin Wang Haibo Zeng | 2020 | Light(Science & Applications)2020，9，1： | 7 |
| 13 | Chinese radioglaciological studies on the Antarctic ice sheet: progress and prospects显示文摘Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work. | CUI Xiangbin WANG Tiantian SUN Bo TANG Xueyuan GUO Jingxue | 2017 | Advances in Polar Science2017，28，3： | 6 |
| 14 | High-precision geochronology of the Early Cretaceous Yingcheng Formation and its stratigraphic implications for Songliao Basin,China显示文摘The Songliao Basin in Northeast Asia is the largest and longest-lived rift basin and preserves a nearcontinuous continental succession of the most of the Cretaceous period,providing great material to investigate the adaption of the terrestrial systems to the Cretaceous greenhouse climate and tectonic events.However,the paucity of precise and accurate radioisotopic ages from the Early Cretaceous strata of the Songliao Basin has greatly held back the temporal and causal correlation of the continental records to the global Early Cretaceous records.Three tuff layers intercalated in the Yingcheng Formation have been intercepted by the SK-2 borehole,which offer excellent materials for radioisotopic dating and calibration of the chronostratigraphy of the Lower Cretaceous sequence of Songliao Basin.Moreover,the Yingcheng Formation recorded the largest and the last of the two major volcanic events in Songliao Basin,which also represents a turning point in the basin evolution history of Songliao from syn-rift stage to post-rift stage.Here we report high-precision U–Pb zircon geochronology by the CA-ID-TIMS technique on three tuff samples from the Yingcheng Formation of the SK-2 borehole in the Songliao Basin to construct a greatly improved,absolute age framework for the Yingcheng Formation and provide crucial age constraints for the Songliao Lower Cretaceous Strata.The new CA-ID-TIMS geochronology constrained the Yingcheng Formation at 102.571+0.320/-2.346 Ma to ca.113 Ma,correlating to the Albian Stage.Combined with the previous published Songliao geochronology,the Quantou Formation is constrained to between 96.442+0.475/-0.086 Ma and 91.923+0.475/-0.086 Ma;the Denglouku Formation is constrained to between 102.571+0.320/-2.346 Ma and 96.442+0.475/-0.086 Ma;the age of the Shahezi Formation is estimated at ca.113 Ma to ca.118 Ma,which could extend to ca.125 Ma in some locations in Songliao Basin.The major unconformity between the Yingcheng Formation and the Denglouku Formation,which represents the transition of the basin from syn-rift to post-rift is thus confined to between 102.571+0.320/-2.346 Ma and 96.442+0.475/-0.086 Ma.This is roughly contemporaneous with the change in the direction of the paleo-Pacific plate motion from west-southwest to north or northwest in mid-Cretaceous,suggesting their possible connections. | Tiantian Wang Chengshan Wang Jahandar Ramezani Xiaoqiao Wan Zhiqiang Yu Youfeng Gao Huaiyu He Huaichun Wu | 2022 | Geoscience Frontiers2022，13，4： | 5 |
| 15 | Clopidogrel improves aspirin response after off-pump coronary artery bypass surgery显示文摘We sought to assess the incidence of aspirin resistance after off-pump coronary artery bypass(OPCAB) surgery,and investigate whether clopidogrel can improve aspirin response and be safely applied early after OPCAB surgery.Sixty patients who underwent standard OPCAB surgery were randomized into two groups.One group(30 patients)received mono-antiplatelet treatment(MAPT) with aspirin 100 mg daily and the other group received dual antiplatelet treatment(DAPT) with aspirin 100 mg daily plus clopidogrel 75 mg daily.Platelet aggregations in response to arachidonic acid(PL_(AA)) and adenosine diphosphate(ADP)(PL_(ADP)) were measured preoperatively and on days 1 to 6,8 and10 after the antiplatelet agents were administered.A PL_(AA) level above 20%was defined as aspirin resistance.Postoperative bleeding and other perioperative variables were also recorded.There were no significant differences between the two groups in baseline characteristics,average number of distal anastomosis,operation time,postoperative bleeding,ventilation time and postoperative hospital stay.However,the incidence of aspirin resistance was significantly lower in the DAPT group than that in the MAPT group on the first and second day after antiplatelet agents were given(62.1%vs.32.1%,34.5%vs.10.7%,respectively,both P < 0.05).There was no significant difference in postoperative complication between the two groups.DAPT with aspirin and clopidogrel can be safely applied to OPCAB patients early after the procedure.Moreover,clopidogrel reduces the incidence of OPCAB-related aspirin resistance. | Xuezhong Wang Xiaoxuan Gong Tiantian Zhu Qiu Zhang Yangyang Zhang Xiaowei Wang Zhijian Yang Chunjian Lia | 2014 | The Journal of Biomedical Research2014，28，2： | 5 |
| 16 | Metabolic characteristics and nutrient utilization in high-feedefficiency pigs selected using different feed conversion ratio models显示文摘An understanding of the nutrient utilization characteristics of pigs with different feed efficiencies(FEs) will help us to develop new strategies to reduce the costs of pig production.In this study,we selected pigs with a range of FEs according to two feed conversion ratio models: the feed intake(FI) model,where pigs had the same average daily gains(ADGs) but different FIs,and the ADG model,where pigs had the same FIs but different ADGs.High-FE pigs had a higher abundance of short chain fatty acid(SCFA)-producing bacteria(Lachnospiraceae,Clostridiaceae1,and Coriobacteriaceae) in their caecum in the FI model,and low-FE pigs had a higher abundance of two families(BacteroidalesS247group and Peptococcaceae) and two genera(Anaerotruncus and CandidatusSoleaferrea) in both models.By contrast,high-FE pigs had more goblet cells and higher m RNA expression of insulin-like growth factor 1(IGF-1) in the FI model,and higher mRNA expression of occludin but lower expressions of adenosine monophosphate-activated protein kinase(AMPK)-α2 and peroxisome proliferator-activated receptor gamma coactivator 1 alpha(PGC1α) in the ADG model.These findings suggest that the presence of SCFA-producing bacteria in the caecum and increased muscular growth may contribute to the high FE of low-FI pigs,while improved intestinal functions and decreased mitochondrial activity in the skeletal muscle are related to the high FE of high-ADG pigs. | Beibei He Tiantian Li Wei Wang Hang Gao Yu Bai Shuai Zhang Jianjun Zang Defa Li Junjun Wang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
| 17 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 18 | 3D Printed Integrated Gradient-Conductive MXene/CNT/Polyimide Aerogel Frames for Electromagnetic Interference Shielding with Ultra-Low Reflection显示文摘Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace. | Tiantian Xue Yi Yang Dingyi Yu Qamar Wali Zhenyu Wang Xuesong Cao Wei Fan Tianxi Liu | 2023 | Nano-Micro Letters2023，15，3： | 5 |
| 19 | The absorption kinetics of Antarctic krill oil phospholipid liposome in blood and the digestive tract of healthy mice by single gavage显示文摘Antarctic krill(Euphausia superba)oil has been gaining increasing attention due to its nutritional and functional potentials.Krill oil usually contains a high concentration(about 50%)of phospholipids(AKOP)rich in DHA and EPA accompanied with 30%–40%triacylglycerols.Phospholipids can be made into liposomes without emulsifiers due to its amphiphilic characteristics.However,the absorption kinetics of AKOP liposome in vivo is not clear,which restrict the molecular mechanism analysis related to its distinct bioactivities.The lipid analysis in serum,small intestinal content and wall was carried out after oral administration of AKOP liposome to illustrate its absorption kinetics in blood and the digestive tract of healthy mice by single gavage.The major type of the obtained AKOP was phosphatidylcholine,and the total contents of the DHA and EPA were 29.31%.AKOP liposome was almost completely digested in the small intestine in 1 h and the hydrolysis products could be quickly absorbed by intestinal enterocytes.The DHA in serum peaked at 2 h after administration of AKOP liposome.AKOP liposome could be quickly digested and absorbed in vivo.The obtained results might provide a scientific basis for the molecular mechanism analysis related to distinct bioactivities of Antarctic krill oil phospholipid. | Lin Li Chengcheng Wang Shan Jiang Rong Li Tiantian Zhang Changhu Xue Teruyoshi Yanagita Xiaoming Jiang Yuming Wang | 2020 | Food Science and Human Wellness2020，9，1： | 4 |
| 20 | Hierarchical graphene@MXene composite foam modified with flower-shaped FeS for efficient and broadband electromagnetic absorption显示文摘Developing high-performance broadband microwave absorption material becomes an urgent concern in the field of electromagnetic protection.In this work,an ultralight magnetic composite foam was con-structed by electrostatic self-assembly of MXene on the surface of graphene skeletons,and subsequent hydrothermal anchoring of flower-shaped FeS clusters.Under the synergistic effect of MXene coating in-creasing conductive loss and FeS clusters improving magnetic loss,the rational construction of hierarchi-cal impedance structure in foam can effectively promote the entrance and consumption of more incident electromagnetic waves.The minimum reflection loss(RL min)reaches-47.17 dB at a thickness of 4.78 mm,and the corresponding effective absorption bandwidth(EAB)is up to 6.15 GHz.More importantly,the microwave absorption performance of composite foam can be further optimized by controlling the load-ing of MXene and thermal treatment at a low temperature.The maximum of EAB for GMF-300 can be extended to an unprecedented value of 11.20 GHz(covering 6.10-17.30 GHz). | Shuangshuang Li Xinwei Tang Xu Zhao Shijie Lu Jiangtao Luo Zheyuan Chai Tiantian Ma Qianqian Lan Piming Ma Weifu Dong Zicheng Wang Tianxi Liu | 2023 | Journal of Materials Science & Technology2023，，2： | 4 |
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