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| 1 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 2 | Endoscopic mucosalresection of flat and sessile colorectal adenomas: our experiencewith long-term follow-ups显示文摘 | GrgOv S Dugalic P Tomasevic R | 2014 | Vojnosanit Pregl2014，71，1： | 1 |
| 3 | Comparative evaluation of di- mensional accuracy of different polyvinyl siloxane putty-wash impression techniques-in vitro study显示文摘 | Dugal R Railkar B Musani S | 2013 | J Int Oral Health2013，5，5： | 1 |
| 4 | Designing a heterogeneous catalyst for the production of adipic acid by aerial oxidation of cyclohexane显示文摘 | Sankar G Raja R | 2000 | Angew Chem Int Ed2000，39，13： | 1 |
| 5 | Low-grade fibromyxoid sarcoma of the liver: A case report显示文摘BACKGROUND Low grade fibromyxoid sarcoma(LGFMS)is a rare and benign mesenchymal tumor with indolent course,most commonly found in young or middle-aged men.The majority of the LGFMSs are located in the trunk and deep soft tissue of the lower extremities.They appear as well circumscribed,although not encapsulated,which often leads to incomplete surgical resection.Despite their seemingly benign appearance,these tumors have aggressive behavior with high metastatic and recurrence rates.Accurate histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise diagnosis.CASE SUMMARY We report a case of a 38 year-old-man who presented with jaundice and upper abdominal discomfort.Multi-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass,extending to the hepatoduodenal ligament.Left hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic vein.Histopathologic examination confirmed the tumor being a low-grade fibromyxoid sarcoma.Three and a half years after surgery,the patient died after being diagnosed with spine metastasis.CONCLUSION Due to poor response to all modalities of adjuvant treatment,we consider that the focus of treatment should be on surgery as the only option for curing the disease. | Vladimir Dugalic Igor I Ignjatovic Jelena Djokic Kovac Nikola Ilic Jelena Sopta Slavenko R Ostojic Dragan Vasin Marko D Bogdanovic Igor Dumic Tamara Milovanovic | 2021 | World Journal of Clinical Cases2021，9，1： | 1 |
| 6 | The Efficacy of Sulodexide in the Prevention of Postthrombotie Syndrome 显示文摘 | Luzzi R Belcaro G Dugall M | 2014 | Clin Appl Thromb Hemost2014，20，6： | 1 |
| 7 | Endoscopic mucosal re- section of flat and sessile colorectal adenomas: our experience with long-term follow-ups显示文摘 | Grgov S Dugalic P Tomasevic R | 2014 | Vojnosanit Preg12014，71，1： | 1 |
| 8 | The efficacy of sulodexide in the prevention of postthrombotic syndrome 显示文摘 | Luzzi R Belcaro G Dugall M | 2014 | Clin Appl Thromb Hemost2014，20，6： | 1 |
| 9 | Comprehensive Screening Procedure for Diuretics in Urine by High - performance Liquid Chromatography显示文摘 | Cooper S F Masse R Dugal R | 1989 | J Chomatogr1989，489，： | 1 |
| 10 | Endoskopischer Ultraschall für die Differenzialdiagnose von L?sionen des Zw?lffingerdarms显示文摘 | A. Pavlovic Markovic T. R?sch T. Alempijevic M. Krstic D. Tomic P. Dugalic A. Sokic Milutinovic M. Bulajic | 2012 | Ultraschall in Med2012，，07： | 1 |
| 11 | 显示文摘 | Sanker G Raja R | 2000 | Angew Chem Int E2000，39，： | 1 |
| 12 | Skeletal and dental changes with nonextraction Begg mechanotherapy in patients with Class Ⅱ Division 1 malocclusion 显示文摘 | Redaly P Kharbanda OP Dugal R | 2000 | Am J Orthod and Orthop2000，118，6： | 1 |
| 13 | Designing a heterogeneous catalyst for the production of adipic acid by aerial oxidation of cyclohex- ane显示文摘 | Dugal M Sankar G Raja R | 2000 | Angew Chem Int Ed2000，39，13： | 1 |
| 14 | Designing a heterogeneous catalyst for the production of adipic acid by aerial oxidation of cyclohexane 显示文摘 | Dugal M Sankar G Raja R | 2000 | Angewandte Chemie-Internation Edition2000，39，3： | 1 |
| 15 | Comparison of usefulness of estradiol vaginal tablets and estriol vagitories for treatment of vaginal atrophy显示文摘 | Dugal R Hesla K Sordal T | 2000 | Acta Obstet Gynecol Scand2000，79，4： | 1 |
| 16 | Functional inter- relations between nucleus raphe dorsalis and nucleus raphe medianus:a dual probe microdialysis study of glutamate-stimu- lated serotonin release 显示文摘 | Mokler D J Dugal J R Hoffman J M | 2009 | Brain Res Bull2009，78，45： | 1 |
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