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| 1 | Trypanosoma cruzi : Molecular characterization of an RNA binding protein differentially expressed in the parasite life cycle显示文摘 | Leticia Pérez-Díaz María Ana Duhagon Pablo Smircich José Sotelo-Silveira Carlos Robello Marco Aurelio Krieger Samuel Goldenberg Noreen Williams Bruno Dallagiovanna Beatriz Garat | 2007 | Experimental Parasitology2007，，： | 1 |
| 2 | Long-range enhancers on 8q24 regulate c-Myc 显示文摘 | Sotelo J Esposito D Duhagon MA | 2010 | Proc Natl Acad Sci U S A2010，107，7： | 1 |
| 3 | BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer显示文摘 | Crea F Duhagon Serrat MA Hurt EM | 2011 | Int J Cancer2011，128，8： | 1 |
| 4 | Longrange enhancers on 8q24 regulate c-Myc显示文摘 | Sotelo J Esposito D Duhagon MA | 2010 | Proc Natl Acad Sci U S A2010，107，： | 1 |
| 5 | Genomic profi- ling of tumor initiating prostatospheres显示文摘 | Duhagon M A Hurt E M Sotelo-Silveira J R | 2010 | BMC Genomics2010，11，： | 1 |
| 6 | BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer 显示文摘 | Crea F Duhagon Sen-at MA Hart EM | 2011 | Int J Cancer2011，128，8： | 1 |
| 7 | BMIl silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer显示文摘 | Crea F Duhagon Serrat MA Hurt EM | 2011 | Int J Cancer2011，128，8： | 1 |
| 8 | Active infective endocarditis in infants and childhood:ten-year review of surgical therapy 显示文摘 | Picarelli D Leone R Duhagon P | 1997 | J Card Surg1997，12，6： | 1 |
| 9 | Active infective endocarditis in infants and childhood:ten-year review of surgical therapy显示文摘 | Picarelli D Leone R Duhagon P | 1997 | J Card Surg1997，12，6： | 1 |
| 10 | Active infective endocarditis in infants and childhood:ten-year review of surgical therapy 显示文摘 | Picarelli D Leone R Duhagon P | 1997 | J Card Surg1997，12，6： | 1 |
| 11 | Bmil silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer 显示文摘 | Crea F Duhagon Serrat MA Hurt EM | 2011 | Int J Cancer2011，128，8： | 1 |
| 12 | BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer显示文摘 | Crea F Duhagon Serrat MA Hurt EM | 2011 | IntJ Cancer2011，128，8： | 1 |
| 13 | Conserved Curvature of RNA Polymerase Ⅰ Core Promoter Beyond rRNA Genes: The Case of the Tritryps显示文摘In trypanosomatids, the RNA polymerase I(RNAPI)-dependent promoters controlling the ribosomal RNA(r RNA) genes have been well identified. Although the RNAPI transcription machinery recognizes the DNA conformation instead of the DNA sequence of promoters, no conformational study has been reported for these promoters. Here we present the in silico analysis of the intrinsic DNA curvature of the r RNA gene core promoters in Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. We found that, in spite of the absence of sequence conservation, these promoters hold conformational properties similar to other eukaryotic r RNA promoters. Our results also indicated that the intrinsic DNA curvature pattern is conserved within the Leishmania genus and also among strains of T. cruzi and T. brucei. Furthermore, we analyzed the impact of point mutations on the intrinsic curvature and their impact on the promoter activity. Furthermore, we found that the core promoters of protein-coding genes transcribed by RNAPI in T. brucei show the same conserved conformational characteristics. Overall, our results indicate that DNA intrinsic curvature of the r RNA gene core promoters is conserved in these ancient eukaryotes and such conserved curvature might be a requirement of RNAPI machinery for transcription of not only r RNA genes but also protein-coding genes. | Pablo Smircich María Ana Duhagon Beatriz Garat | 2015 | Genomics, Proteomics & Bioinformatics2015，13，6： | 0 |
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