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| 1 | Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis sp.HB-J378显示文摘Marine natural products have become an increasingly important source of new drug leads during recent years.In an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis sp.strain HB-J378.Notably,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these angucyclines.The structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS data.Nocardiopsistins A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,chloramphenicol.Bioinformatic analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins. | Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining Zhu Peter J.McCarthy Amy E.Wright Guojun Wang | 2018 | Synthetic and Systems Biotechnology2018，3，4： | 3 |
| 2 | Pulling the Levers: Transformational Leadership, Public Service Motivation, and Mission Valence显示文摘 | Bradley E.Wright Donald P.Moynihan Sanjay K.Pandey | 2012 | Public Administration Review2012，，2： | 1 |
| 3 | Replica plating of mammalian cells using low melt agarose显示文摘 | Shobhana Natarajan Tracy T.Chow Jerry W.Shay Woodring E.Wright | | 0，，： | 1 |
| 4 | Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity显示文摘Exercise benefits the musculoskeletal system and reduces the effects of cancer.The effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence outcomes.Mechanical signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer progression.We examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration.Low-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and RANKL.Furthermore,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive capacity.Disconnecting the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor secretion.LIV increased cell stiffness;an effect dependent on the LINC complex.These data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling. | Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad Theresa A.Guise William R.Thompson | 2020 | Bone Research2020，8，4： | 1 |
| 5 | Short- run and Long- run Determinants of the Price of Gold显示文摘 | Eric J.Levin Robert E.Wright | | 0，，32： | 1 |
| 6 | ABSORPTION LINES IN THE SPECTRA OF THE QSO PKS 1448-232显示文摘I. OLD AND NEW OBSERVATIONS Savage, Bolton and Wright, found that the radio source PKS 1448-232 coincided with a stellar object of a magnitude about 16.4 having an ultraviolet excess. A lowresolution spectrum obtained with the Anglo-Australian 3.m9 Telescope (AAT) confirmed this object to be a QSO with zem=2.22, and revealed many absorption | 陈建生 DONALD C.MORTON BRUCE A.PETERSON ALAN E.WRIGHT DAVID L.JAUNCEY | 1983 | Chinese Science Bulletin1983，28，8： | 0 |
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