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| 1 | Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia显示文摘AIM To evaluate factors associated with Clostridium difficile infection (CDI) and outcomes of CDI in the myelodysplastic syndrome(MDS) and acute myeloid leukemia (AML) population.METHODS After IRB approval,all MDS/AML patients hospitalized at the University of Maryland Greenebaum Comprehensive Cancer Center between August 2011 and December 2013 were identified.Medical charts were reviewed for demographics,clinical information,development of CDI,complications of CDI,and mortality.Patients with CDI,defined as having a positive stool PCR done for clinical suspicion of CDI,were compared to those without CDI in order to identify predictors of disease.A t-test was used for comparison of continuous variables and chisquare or Fisher's exact tests were used for categorical variables,as appropriate.RESULTS Two hundred and twenty-three patients (60.1% male,mean age 61.3 years,13% MDS,87% AML) had 594 unique hospitalizations during the study period.Thirtyfour patients (15.2%) were diagnosed with CDI.Factors significantly associated with CDI included lower albumin at time of hospitalization (P < 0.0001),prior diagnosis of CDI (P < 0.0001),receipt of cytarabine-based chemotherapy (P = 0.015),total days of neutropenia (P = 0.014),and total days of hospitalization (P = 0.005).Gender (P = 0.10),age (P = 0.77),proton-pump inhibitor use (P = 0.73),receipt of antibiotics (P = 0.66),and receipt of DNA hypomethylating agent-based chemotherapy (P = 0.92) were not significantly associated with CDI.CONCLUSION CDI is common in the MDS/AML population.Factors significantly associated with CDI in this population include low albumin,prior CDI,use of cytarabine-based chemotherapy,and prolonged neutropenia.In this study,we have identified a subset of patients in which prophylaxis studies could be targeted. | Kamini Shah Bryan F Curtin Christopher Chu Daniel Hwang Mark H Flasar Erik von Rosenvinge | 2017 | World Journal of Clinical Oncology2017，8，5： | 3 |
| 2 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 3 | Development and test of small-scale batch fired Straw boilers in Denmark显示文摘 | Erik F K Jens K K | 2004 | Biomass and Bioenergy2004，26，： | 1 |
| 4 | Memory - based shallow parsing 显示文摘 | Erik F Sang Tjong Kim | 2002 | Machine Learning Research2002，2，3： | 1 |
| 5 | A high-throughput methodology for screening solution-based chelating agents for efficient palladium removal显示文摘 | ERIK F BRIGITTE E SHU Y | 2007 | QSAR & Combinatorial Science2007，26，5： | 1 |
| 6 | Development of an Effective Palladium Removal Process for VEGF Oncology Candidate AG13736 and a Simple,Efficient Screening Technique for Scavenger Reagent Identification显示文摘 | ERIK J F BRIGITTE L E NEAL W S | 2008 | Organic Process Research & Development2008，，12： | 1 |
| 7 | The reductive ring cleavage of 1,3 - disubstituted imidazolium idiodes by soditnn borohydride显示文摘 | Erik F Godefroi | 1967 | J Org Chem1967，32，： | 1 |
| 8 | Human herpes virus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phos phorylates zdovudine but not ganciclovir显示文摘 | ERIK A G RAYMOND F S JOYCE D F | 2000 | J Virol2000，74，2： | 1 |
| 9 | Sensor placement for fault diagno sis 显示文摘 | Krasander M Erik F | 2008 | IEEE Transactions on Systems Man and Cyber netics-Part A: Systems and Humans2008，38，6： | 1 |
| 10 | Information Technology,Workplace Organization and the Demand for Skilled Labor:Firm-Level Evidence显示文摘 | Bresnahan F Timothy B Erik M H Lorin | 2002 | Quarterly Journal of Economics2002，117，1： | 1 |
| 11 | Bionechcnics of locked plates and screws 显示文摘 | Kenreth A Erik N Eric F | 2004 | J Orthop Trauma2004，18，： | 1 |
| 12 | Assessing health consequences in an environmental impact assessment: The case of Amsterdam Airport Schiphol显示文摘 | ELLIS A M F BRIGIT A M S ERIK L | 2002 | Environmental Impact Assessment Review2002，，22： | 1 |
| 13 | Development and test of small scale batch fired straw boilers in denmark 显示文摘 | ERIK F K JENS K K | 2004 | Biomass and Bioen-ergy2004，26，： | 1 |
| 14 | Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: A European population- based multicenter study显示文摘 | Erik F Vedat T Jan-Jaap H | 2008 | JARO2008，9，： | 1 |
| 15 | A prospecitive comparative study between push-enterscopy and wirless video capsule in patients with obscure digestive bleeding显示文摘 | Andre VG Erik F Alain S | 2002 | Gastrointest Endose2002，55，： | 1 |
| 16 | Synthesis,Structures,and Reactivity of (R6-acen) ZrR2 and (R6-acen) Zr (R') + Complexes (R =H,F,R' =CH2 CMe3,CH2 Ph)显示文摘 | Erik B Tjaden Dale C Swenson Richard F Jordan | | 0，，01： | 1 |
| 17 | Antiviral prodrugs-the development of successful prodrug strategies for antiviral chemotherapy显示文摘 | ERIK D C HUGH J F | 2006 | Br J Pharmacol2006，147，1： | 1 |
| 18 | Bone mineral density and bone- markers in patients with a recent low - energy fracture : effect of 1 y of treatment with calcium and vitamin D 显示文摘 | Mette F Jens - Erik BJ Eskildsen PC | 2007 | Am J Clin Nutr2007，86，1： | 1 |
| 19 | Polyanion hydro-phobicity and protein basicity affect protein stabilityin protein-polyanion complexes显示文摘 | Erik S Diana F Vera V | 2009 | Biomacromole-cules2009，109，： | 1 |
| 20 | Energy saving by firms:decision-making,barriers and policies显示文摘 | HENRI L F DE GROOT ERIK T VERHOEF PETER NIJKAMP | 2001 | Energy Economics2001，23，6： | 1 |
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