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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Risk of incomplete pyloromyotomy and mucosal perforation in open and laparoscopic pyloromyotomy显示文摘 | Nigel Hall Simon Eaton Aaron Seims | 2014 | Pediatr Surg2014，，49： | 1 |
| 3 | Intestinal ischemia reperfusion injury and multisystem organ failure显示文摘 | Agostino Pierro Simon Eaton | 2004 | Seminars in Pediatric Surgery2004，，1： | 1 |
| 4 | Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene显示文摘 | Khalid Hussain Peter T. Clayton Steve Krywawych Ilenia Chatziandreou Phillipa Mills D.W. Ginbey Ans J.J.M. Geboers Ruud Berger Inge E.T. van den Berg Simon Eaton | 2005 | The Journal of Pediatrics2005，，5： | 1 |
| 5 | Neonatal endotoxemia affects heart but not kidney bioenergetics显示文摘 | Koji Fukumoto Agostino Pierro Lewis Spitz Simon Eaton | 2003 | Journal of Pediatric Surgery2003，，5： | 1 |
| 6 | Association of sterol-and glycosyl phosphatidy linositol-linked proteins with drosophila raft lipid microdomains显示文摘 | Rietveld A Neutz S Simons K Eaton S | 1999 | Biol Chem1999，274，12： | 1 |
| 7 | Intestinal ischemia reperfusion injury and multisystem organ failure显示文摘 | Agostino P Simon Eaton | 2004 | Seminars Pediat Surg2004，13，1： | 1 |
| 8 | Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: Effects of glutamine 显示文摘 | Markley Miehele A Pierro Agostino Eaton Simon | 2002 | Clinical Science (London)2002，102，3： | 1 |
| 9 | International Survey on the Management of Esophageal Atresia显示文摘 | Augusto Zani Simon Eaton Michael Hoellwarth Prem Puri Juan Tovar Guenter Fasching Pietro Bagolan Marija Lukac Rene Wijnen Joachim Kuebler Giovanni Cecchetto Risto Rintala Agostino Pierro | 2013 | Eur J Pediatr Surg2013，，： | 1 |
| 10 | Control of mitochondrial β-oxidation flux显示文摘 | Simon Eaton | 2002 | Progress in Lipid Research2002，，3： | 1 |
| 11 | Inflammatory response in children after laparoscopic vs open Nissen fundoplication: randomized con- trolled trlal显示文摘 | Merrill McHoneya Simon Eaton | 2005 | Journal of Pediatric Surgery2005，40，： | 1 |
| 12 | Vascular Risk Factors and Diabetic Neuropathy显示文摘 | Nish Chaturvedi Simon EM Eaton | 2005 | N Engl J Med2005，352，： | 1 |
| 13 | Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2显示文摘 | Demetra Mavri-Damelin Simon Eaton Leonard H. Damelin Myrddin Rees Humphrey J.F. Hodgson Clare Selden | 2006 | International Journal of Biochemistry and Cell Biology2006，，3： | 1 |
| 14 | 开腹与腹腔镜幽门肌切开术治疗幽门狭窄的疗效比较:一项多中心、双盲、随机对照试验显示文摘背景:腹腔镜幽门肌切开术治疗婴儿幽门狭窄已被广泛采用,但其疗效尚有待证实。本研究旨在比较开腹与腹腔镜幽门肌切开术治疗幽门狭窄的疗效。方法:2004年6月至2007年5月间,作者在6个三级儿童外科中心进行了一项国际多中心、双盲、随机对照试验。180例患儿被随机分配接受开腹幽门肌切开术(n=93)或腹腔镜幽门肌切开术(n=87)治疗,使两组之间年龄、体重、小生时胎龄、最初就诊时的碳酸氢盐水平、喂养类型、术前症状持续时间以及所属中心的差别最小化。纳入标准为确诊幽门狭窄的婴儿。主要终点指标为达到全胃肠喂养的时间和术后恢复时间。 | Nigel J Hall Maurizio Pacilli Simon Eaton | 2009 | 世界临床医学2009，，8： | 0 |
| 15 | 基于前馈人工神经网络的核反应堆反应性估算显示文摘运用前馈人工神经网络(ANN)方法对有效增殖系数keff进行了估算,keff是具有一定装料方式(LP)的核反应堆反应性的重要参数。在核工程领域里,keff通常通过计算机数学模型来计算,例如蒙特卡罗模型和有限元模型,这些模型可能消耗大量的计算机资源。在某些需要进行大量反应堆仿真的情况下(例如,在10^10-10^100的求解空间中寻找一个使丘孵最大的最优LP),需要的计算时间非常长且不切实际。为此,本文通过使用已知的LP和相应的keff训练了一种前馈ANN,以进行快速和准确的keff估算。实验结果表明,所提出的ANN能够提供快速、准确和实用的keff估算。 | Shan Jiang Christopher C Pain Jonathan N Carter Ahmet K Ziver Matthew D Eaton Anthony J H Goddard Simon J Franklin Heather J Phillips 蔡志云(译) | 2009 | 国外核动力2009，30，6： | 0 |
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