|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Positive outlook for China textile and apparel industry显示文摘In recent years, Haian, Jiangsu Province, has guided the upgrading of traditional textile industry and encouraged Haian textile industry to gradually develop from traditional industry and characteristic industry to dominant industry and strong industry. | People’s Daily Overseas Edition | 2019 | China Textile2019，，5： | 1 |
| 2 | Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure显示文摘 | Ana Margarida Teixeira Patrícia Garrido Paulo Santos Rui Alves Belmiro Parada Elísio Costa Anabela Almeida Edite Teixeira-Lemos José Sereno Rui Pinto Luís Belo Alice Santos-Silva Frederico Teixeira Flávio Reis | 2010 | Renal Failure2010，，9： | 1 |
| 3 | Citrullination under physiological and pathological conditions显示文摘 | Zsuzsanna Baka Bence Gy?rgy Pál Géher Edit I. Buzás András Falus Gy?rgy Nagy | 2012 | Joint Bone Spine2012，，5： | 1 |
| 4 | p53 expression in gastric cancer: Clinicopathological correlation and prognostic significance显示文摘 | Monig SP Edit S Zirbes TK | 1997 | Dig Dis Sci1997，42，12： | 1 |
| 5 | Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma显示文摘 | Marta Hegyi ágnes Gulácsi Edit Cságoly Katalin Csordás Olivér Eipel Dániel Erdélyi Judit Müller Karolina Nemes Orsolya Lautner-Csorba Gábor Kovács | 2012 | Journal of Cancer Research and Clinical Oncology2012，，10： | 1 |
| 6 | Determination of ethyl carbarnate in palinka spirits by liquid chromatography-electrospray tandem mass spectrometry after derivatization显示文摘 | EDIT D ATTILA G EVA S B | 2010 | Food Research International2010，43，10： | 1 |
| 7 | Dendrimers as building block for multilayer construction 显示文摘 | Edition Watanabe S Regen S L | 1994 | Journal of the American Chemical Society1994，116，5： | 1 |
| 8 | Copper plating on and elec trical investigation of a lowpermittivity cycloolefin-copolymer显示文摘 | Andrea Edit Pap Krisztia'n Korda's Heli Jantunen Esa Haapaniemi Seppo Leppa'vuori | 2003 | Polymer Testing2003，，22： | 1 |
| 9 | Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio显示文摘We present new quantitative model describing the pressure dependence of acoustic P-and S-wave velocities.Assuming that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure function.We estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity data.As is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are assumed.Increasing the number of exponential terms leads to highly nonlinear ill-posed inverse problem.Due to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as unknowns.The characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity data.The characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical cracks.This gives the possibility to estimate the aspect ratios in terms of the characteristic pressures. | Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 10 | Oligoclonal IgG bands in the cerebrospinal fluid of Portuguese patients with multiple sclerosis显示文摘 | Maria José S Lucinda Sequeira Maria Edite Rio | 2005 | Arq Neuropsiquiatr2005，63，2： | 1 |
| 11 | Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors显示文摘Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods.Digital drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted agents.DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial.The aim of this study was to evaluate the utility of DDA in pediatric oncology.Methods Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further analysis.Tissue or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support.Finally,a molecular tumor board(MTB)evaluated the results to provide therapy recommendations.Results Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing results.DDA identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug resistance.Actionability reached 88%(29/33)by 2020 due to the continuous updates of the evidence database.MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed therapies.Filtering of WES results for targeted panels missed important mutations affecting therapy selection.Conclusions DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers.Knowledgebase updates enable automatic interpretation of a continuously expanding gene set,a“virtual”panel,filtered out from genome-wide analysis to always maximize the performance of precision treatment planning. | Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták | 2023 | World Journal of Pediatrics2023，19，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员