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| 1 | Immune checkpoint inhibitors in cancer therapy显示文摘In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4(CTLA-4) and programmed cell death protein 1(PD-1) which have been shown to have potent immunomodulatory effects through their function as negative regulators of T cell activation. CTLA-4, through engagement with its ligands B7-1(CD80) and B7-2(CD86), plays a pivotal role in attenuating the activation of naive and memory T cells. In contrast, PD-1 is primarily involved in modulating T cell activity in peripheral tissues via its interaction with PD-L1 and PD-L2. The discovery of these negative regulators of the immune response was crucial in the development of checkpoint inhibitors. This shifted the focus from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses. | Eika S.Webb Peng Liu Renato Baleeiro Nicholas R.Lemoine Ming Yuan Yaohe Wang | 2018 | The Journal of Biomedical Research2018，32，5： | 8 |
| 2 | Ni-Mo基催化剂上卟啉加氢脱氮(英文)显示文摘The hydrodenitrogenation(HDN) of porphyrins was carried out over a series of phosphorus containing NiMo/Al 2 O 3 catalysts using a fixed‐bed flow reaction system.A method of quantitative analysis of the porphyrin and its derivatives produced by HDN was established.In HDN of porphyrin,four types of hydrocarbons:C8 alkanes,C 8 alkenes,C9 alkanes,and C10 alkanes,and two groups of nitrogen‐containing compounds:alkyl substituted bipyrrolidines(alkylbipyrrolidines) and alkyl substituted tripyrrolidines(alkyltripyrrolidines) were identified.The hydrogenolysis of porphyrins occurred rapidly at lower temperature but higher temperatures were required for the HDN of porphyrins.The NiMoP3 catalyst showed the highest catalytic activity for the HDN of porphyrins.Based on the characterization of the supports and catalysts,it is suggested that the dispersion of Mo is improved and the number of weak acidic sites on the NiMoP catalysts increases with the addition of phosphorus. | Eika W.QIAN Satoshi ABE Yusaku KAGAWA Hiroyuki IKEDA | 2013 | 催化学报2013，34，1： | 5 |
| 3 | Collagen and bladder function in streptozotocin-diabetic rats:effects of insulin and aminoguanidine 显示文摘 | Eika B Levin RM Longhurst PA | 1992 | J Urol1992，148，： | 1 |
| 4 | The CanMEDS, professional role is complexand needs redefinition in Denmark 显示文摘 | Mailing B Eika B | 2013 | Ugeskr Laeger2013，175，24： | 1 |
| 5 | Understanding Stream Geomorphic State in Relation to Ecological Integrity: Evidence Using Habitat Assessments and Macroinvertebrates显示文摘 | S. Ma?eika P. Sullivan Mary C. Watzin W. Cully Hession | 2004 | Environmental Management2004，，5： | 1 |
| 6 | Influence of the dispersion on measurement of phase and group velocities of Lamb waves显示文摘 | Ma?eika L Draudvilien? L ?ukauskas E | 2009 | Ultrasound2009，64，4： | 1 |
| 7 | Investigations of the inspection possibiities of the inner surface of the noz- zle using ultrasonic phased array 显示文摘 | Jasiunien~ E Ma~eika L Tum~ys O | 2010 | ISSN 1392-2114 Ultrasound2010，653，： | 1 |
| 8 | Analysis of the zero-crossing technique in relation to measurements of phase velocities of the Lamb waves显示文摘 | Ma?eika L Draudvilien? L | 2010 | Ultrasound2010，66，2： | 1 |
| 9 | A riverscape per- spective on habitat associations among riverine bird assemblages in the Lake Champlain Basin, USA显示文摘 | Maz v Eika S Sullivan P Watzin M C | 2007 | Landscape Ecology2007，22，： | 1 |
| 10 | Air-coupled ultrasonic investigation of multi-layered composite materials显示文摘 | R. Ka?ys A. Dem?enko E. ?ukauskas L. Ma?eika | 2006 | Ultrasonics2006，，： | 1 |
| 11 | Nursing staff interac- tions during the older residents' transition into long-termcare facility in a nursing home in rural Norway:an ethnographic study 显示文摘 | Eika M Dale B Espnes GA | 2015 | BMC Health Serv Res2015，15，1： | 1 |
| 12 | Oxidative desulfurization and denitrogenation of a light gas oil using an oxidation/adsorption continuous flow process显示文摘 | ISHIHARA A WANG D DUMEIGNIL F AMANO H EIKA W KABE T | 2005 | Appl Catal A2005，279，12： | 1 |
| 13 | Synthesis of poly-sulfide using diisobutylene, sulfur, and hydrogen sulfide oversolid base catalysts 显示文摘 | Eika W Q Shigeru Y Jeayoung L | 2003 | Applied Catalysis A : General2003，53，1： | 1 |
| 14 | Synthesis of di-t-butyl poly- sulfide from isobutene, hydrogen sulfide, and sulfur ( Part 2) catalytic behavior of MFI zeolites显示文摘 | Eika W Q Kazuo H Satoko H | 2009 | Journal of the Japan Petroleum Institute2009，52，3： | 1 |
| 15 | Antioxidative activity in the pericarp and seed of Japanese pepper(xanthoxylum piperitum) DC显示文摘 | Eika Hisatomi Mikiko Matsui Kikue Kubota Akio Kobayashi | | 0，，10： | 1 |
| 16 | Outcome (competency) based education: an exploration of its origins, theoretical basis, and empirical evidence显示文摘 | Morcke AM Doman T Eika B | 2013 | Adv Health Sci Educ Theory Pract2013，18，： | 1 |
| 17 | Heparin-induced thrombocytopenia显示文摘 | Eika C Godal HC Laake K | 1980 | Scandinavian Journal of Hematology1980，25，： | 1 |
| 18 | Outcome (competency) based education: an exploration of its origins, theoretical basis, and empirical evidence显示文摘 | Morcke AM Dornan T Eika B | 2013 | Adv Health Sci Educ Theory Pract2013，18，： | 1 |
| 19 | Epidermal growth factor attenuates the sclerotherapy-induced biomechanical properties of the oesophagus : An experimential study in minipigs显示文摘 | Vinter-Jenser L Eika B Gregersen H | 1995 | Stand Gastroenteral1995，30，7： | 1 |
| 20 | Calculation of Lamb wavesdispersion curves in multi-layered planar structures显示文摘 | Dem Enko A Ma Eika L | 2002 | Ultragarsas2002，44，3： | 1 |
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