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| 1 | Hepatic schwannoma:Imaging findings on CT,MRI and contrast-enhanced ultrasonography显示文摘A primary benign schwannoma of the liver is extremely rare and is difficult to preoperatively discriminate from a malignant tumor.We compared the imaging and pathological findings,and examined the possibility of preoperatively diagnosing a benign liver schwannoma.A 72-year-old woman was admitted to our hospital because of a 4.6-cm mass in the liver.A malignant tumor was suspected,and a right hepatectomy was performed.After this,the diagnosis of a primary benign schwannoma of the liver was made through pathological examination.Contrast-enhanced ultrasonography(CEUS) with Sonazoid showed minute blood flows into the septum and solid areas of the tumor in the vascular phase;most likely due to increased arterial flow associated with infiltration of chronic inflammatory cells.In the postvascular phase,CEUS showed contrast defect of cystic areas and delayed enhancement of solid areas;most likely due to aggregation of siderophores.Because discriminating between a benign and malignant schwannoma of the liver is difficult,surgery is generally recommended.However,the two key findings from CEUS may be useful in discriminating ancient schwannoma by recognizing the hemorrhage involved in the secondary degeneration and aggregation of siderophores. | Yu Ota Kazunobu Aso Kenji Watanabe Takahiro Einama Koji Imai Hidenori Karasaki Ryuji Sudo Yosui Tamaki Mituyoshi Okada Yosihiko Tokusashi Toru Kono Naoyuki Miyokawa Masakazu Haneda Masahiko Taniguchi Hiroyuki Furukawa | 2012 | World Journal of Gastroenterology2012，18，35： | 11 |
| 2 | Hepatic clearance measured with ^(99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis显示文摘AIM: To evaluate the clinical utility of hepatic clearance(HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin(99mTc-GSA) single-photon emission computed tomography(SPECT) to estimate the degree of liver fibrosis.METHODS:Seventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this study.Indocyanine green clearance(ICG R15),quantitative indices estimated by 99mTc-GSA[the receptor index(LHL15 and HH15)and HC via SPECT analysis],and conventional liver function tests were performed before hepatectomy.Correlations among the quantitative indices for liver functional reserve,conventional liver function tests,andthe degree of liver fibrosis were evaluated.RESULTS:The degree of liver fibrosis was correlated with ICG R15,HH15,LHL15,and HC.HC showed the best correlation with conventional liver function tests.According to multivariate analysis,HC and LHL15 were significant independent predictors of severe fibrosis.HC was the most valuable index for predicting severe fibrosis.CONCLUSION:HC measured with 99mTc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy. | Masahiko Taniguchi Atsutaka Okizaki Kenji Watanabe Koji Imai Koichiro Uchida Takahiro Einama Noriyuki Shuke Naoyuki Miyokawa Hiroyuki Furukawa | 2014 | World Journal of Gastroenterology2014，20，44： | 11 |
| 3 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 4 | PDGFRβ expression in tumor stroma of pancreatic adenocarelnoma as a reliable prognostic marker 显示文摘 | Yuzawa S Kano MR Einama T | 2012 | Med Oncol2012，29，4： | 1 |
| 5 | PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker显示文摘 | Sayaka Yuzawa Mitsunobu R. Kano Takahiro Einama Hiroshi Nishihara | 2012 | Medical Oncology2012，，4： | 1 |
| 6 | High-level Skp2 Expression in Pancreatic Ductal Adenocarcinoma:Correlation with the Extent of Lymph Node Metastasis,Higher Histological Grade,and Poorer Patient Outcome显示文摘 | Einama T Kagata Y Tsuda H | | 0，，04： | 1 |
| 7 | High-level Skp2 expression in pancreatic ductal adenocarcinoma:correlation with the extent of lymph node metastasis,higher histological grade,and poorer patient outcome显示文摘 | EINAMA T KAGATA Y TSUDA H | 2006 | Pancreas2006，32，4： | 1 |
| 8 | Successful curative re- section of gallbladder cancer following S-1 chemotherapy: A case report and review of the literature 显示文摘 | Einama T Uchida K Taniguchi M | 2014 | Oncol Lett2014，8，6： | 1 |
| 9 | Intracellular localization of mesothelin predicts patient prognosisof extrahepatic bile duct cancer显示文摘 | Futoshi Kawamata Hirofumi Kamachi Takahiro Einama Shigenori Homma Munenori Tahara Masaya Miyazaki Shinya Tanaka Toshiya Kamiyama Hiroshi Nishihara Akinobu Taketomi Satoru Todo | 2012 | International Journal of Oncology2012，，： | 1 |
| 10 | C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma显示文摘 | Futoshi Kawamata Shigenori Homma Hirofumi Kamachi Takahiro Einama Yasutaka Kato Masumi Tsuda Shinya Tanaka Masahiro Maeda Kazunori Kajino Okio Hino Norihiko Takahashi Toshiya Kamiyama Hiroshi Nishihara Akinobu Taketomi Satoru Todo | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 11 | Importance of luminal membrane mesothelin expression in intraductalpapillary mucinous neoplasms显示文摘 | Takahiro Einama Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Hiromi Kanno Marin Ishikawa Futoshi Kawamata Yuji Konishi Masanori Sato Munenori Tahara Kuniaki Okada Shunji Muraoka Toshiya Kamiyama Akinobu Taketomi Yoshihiro Matsuno Hiroyuki Furukawa S | 2015 | Oncology Letters2015，，： | 1 |
| 12 | Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma显示文摘 | Einama T Kamachi H Nishihara H | 2011 | Pancreas2011，40，： | 1 |
| 13 | High-level Skp2 expression in pancreatic duetal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome显示文摘 | EINAMA T KAGATA Y TSUDA H | 2006 | Pancreas2006，32，4： | 1 |
| 14 | High-level Skp2 expression in pancreatic ductal adenocarcinoma:correlation with the extent of lymph node metastasis,higher histological grade,and poorer patient outcome显示文摘 | EINAMA T KAGATA Y TSUDA H | 2006 | Pancreas2006，32，4： | 1 |
| 15 | Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma显示文摘 | Einama T Kamachi H Nishihara H | | 0，，： | 1 |
| 16 | High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade and poorer patient outcome 显示文摘 | Einama T Kagata Y Tsuda H | 2006 | 32(4) :376-3812006，32，4： | 1 |
| 17 | Co-expressionof mesothelin and CA125 correlates with unfavorable patientoutcome in pancreatic ductal adenocarcinoma显示文摘 | Einama T Kamachi H Nishihara H | 2011 | Pancreas2011，40，8： | 1 |
| 18 | High-level SKP2expression in pancreatic ductal adenocarcinoma:correlation with the extent of lymph node metastasis,higher histaloglcal grade,and poorer patient outcome显示文摘 | EINAMA T KAGATA Y TSUDA H | 2006 | Pancreas2006，32，4： | 1 |
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