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| 1 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 2 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 3 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 4 | Inhibition by iota-carrageenan of the spread of murine cytomegalovirus from the peritoneal cavity to the blood plasma显示文摘 | Hamasuna R Eizuru Y Minamishima Y | 1994 | Journal of General Virology1994，75，： | 1 |
| 5 | Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir显示文摘 | Harada K Eizuru Y Isashiki Y | 1997 | Arch Virol1997，142，2： | 1 |
| 6 | Surgical Maneuvers Enhance Molecular Detection of Circulating Tumor Cells During Gastric Cancer Surgery显示文摘 | Futoshi Miyazono Shoji Natsugoe Sonshin Takao Koki Tokuda Fumio Kijima Kuniaki Aridome Shuichi Hokita Masamichi Baba Yoshito Eizuru Takashi Aikou | 2001 | Annals of Surgery2001，，： | 1 |
| 7 | Progressive retinitis encephalitis due to ganciclovir-resistant cytomegalovirus associated with aplastiv anemia显示文摘 | Sasaki T Okayama A Eizuru Y | 1997 | Intern Med1997，36，5： | 1 |
| 8 | Autocrine growth ofEpstein-Barr virus-positive gastric carcinoma cells mediated by anEpstein-Barr virus-encoded small RNA 显示文摘 | Iwakiri D Eizuru Y Tokunaga M | 2003 | Cancer Res2003，63，21： | 1 |
| 9 | Human papillomavirus in upper digestive tract tumors from three countries显示文摘AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HPV-positive and HPV-negative cases was also made. RESULTS: HPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16INK4a proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and-negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs. CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus. | Andres Castillo Chihaya Koriyama Michiyo Higashi Muhammad Anwar Mulazim Hussain Bukhari Edwin Carrascal Lida Mancilla Hiroshi Okumura Masataka Matsumoto Kazumasa Sugihara Shoji Natsugoe Yoshito Eizuru Suminori Akiba | 2011 | World Journal of Gastroenterology2011，17，48： | 1 |
| 10 | Nasal natural killer/T- cell lymphoma and its association with type 'i'/XhoI loss strain Epstein-Barr virus in Chile显示文摘 | Cabrera ME Eizuru Y hoh T | 2007 | J Clin Pathol2007，60，6： | 1 |
| 11 | Clinical significance of CEA-mRNA expression in peritoneal lavage fluidfrom patients with gastric cancer显示文摘 | Koki Tokuda Shoji Natsugoe Akihiro Nakajo Futoshi Miyazono Sumiya Ishigami Shuichi Hokita Sonshin Takao Yoshito Eizuru Takashi Aikou | 2003 | International Journal of Molecular Medicine2003，，： | 1 |
| 12 | Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription 显示文摘 | Kusano S Eizuru Y | 2010 | Biochem Biophys Res Commun2010，396，3： | 1 |
| 13 | Autocrine growth of Epstein-Barr virus-positive gastric carcinoma cells mediated by an Epstein-Barr virus-encoded small RNA显示文摘 | Iwakiri D Eizuru Y Tokunaga M | 2003 | Cancer Res2003，63，： | 1 |
| 14 | Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription显示文摘 | Kusano S Eizuru Y | 2010 | Biochem Biophys Res Commun2010，396，3： | 1 |
| 15 | Development of new antivlrals for herpeaviruaes 显示文摘 | Eizuru Y | 2003 | Antivir Chem Chemother2003，14，6： | 1 |
| 16 | Human I-mfa domain proteins specifi cally interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription显示文摘 | S Kusano Y Eizuru | 2010 | Biochem Biophys Res Commun2010，396，3： | 1 |
| 17 | Genetic analysis of a clinical isolate of human cytomegalovirus exhibiting resistance against both ganciclovir and cidofovir显示文摘 | HaradaK Eizuru Y Isashiki Y | | 0，，： | 1 |
| 18 | UL146 variability among clinical isolates of human cytomegalovirus from Japan 显示文摘 | Aguayo F Murayama T Eizuru Y | 2010 | Biol Res2010，43，4： | 1 |
| 19 | Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant显示文摘 | Khan FR Mori S Eizuru Y | 1998 | Antiviral Res1998，40，： | 1 |
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