维普中文期刊产品整合服务
7篇 您的检索式:作者名="Eli Berman"
    题名 作者 年代 出处 被引量
1Environmental regulation and labor demand: evidence from the South Coast Air Basin显示文摘Eli Berman Linda T.M Bui 2001Journal of Public Economics2001,,2:1
2Implications of Skill-Biased Technological Change: International Evidence 显示文摘Eli Berman John Bound Stephen Machin 1998The Quarterly Journal of Economics1998,,4:1
3Im- plications of Skill--Biased Technological Change: International Evidence显示文摘Berman Eli John Bound and Stephen Machin 1998Quarterly Journal of E- conomics1998,,:1
4Changes in the demand for skilled labor within US manufactur- ing: evidence from the annual survey of manufactures 显示文摘Berman Eli John Bound and ZviGriliches 1994The Quarterly Journal of Economics1994,109,2:1
5Language-SkillCom- plementarity: Returns to hnmigrant Language Acquisition 显示文摘Berman Eli Kevin Lang Erez Siniver 2003Labour Economics2003,10,26:1
6Skill-Based Technology Transfer around the World显示文摘Eli Berman Stephen Machin 2000Oxford Review of Economic Policy2000,16,3:1
7Role of nestin in glioma invasion显示文摘AIM: To determine the role for the intermediate filament protein nestin in glioma invasion. METHODS: We examined the expression and function of nestin in gliomas(Grades Ⅱ-Ⅳ as defined by the World Health Organization). We determined nestin expression using Immunohistochemical methods. To elucidate nestin's biological function(s), we reduced m RNA levels by 61% and 87% in two glioblastomaderived neurosphere lines using short hairpin RNAs and determined the effect of reduced nestin expression on glioma cell proliferation and invasion using MTS and matrigel migration assays, respectively. We also utilized quantitative real time polymerase chain reaction assaysto determine the effect of reduced nestin expression on the expression of other markers associated with glioma stem cells and their differentiated progenies. RESULTS: We found a significant correlation between nestin immunoreactivity and astrocytoma tumor grade, with 36% of grade Ⅱ, 75% of grade Ⅲ, and 100% of grade Ⅳtumors expressing significant levels of the protein when assessed using immunohistochemistry. Reduction in nestin expression had no effect on cell growth in culture, but did retard the capacity of one line to migrate in-vitro on matrigel. Interestingly, in the line whose migration was not affected, m RNA levels of a second intermediate filament, synemin(also knowns as desmuslin), were elevated following introduction of sh RNA targeting nestin. As synemin was not induced in the line which required nestin for migration, it is a possibility that synemin may compensate for the loss of nestin in this process. CONCLUSION: Nestin expression is prominent in high-grade astrocytomas. Nestin is not required for cell growth but it may, however, be required for cell motility.Alex Lin Luigi Marchionni Jeffrey Sosnowski David Berman Charles G Eberhart Eli E Bar 2015World Journal of Translational Medicine2015,4,3:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费