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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | 2012 (9851)2012，，9851： | 3 |
| 3 | The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial显示文摘 | Scott D Solomon Michael Zile Burkert Pieske Adriaan Voors Amil Shah Elisabeth Kraigher-Krainer Victor Shi Toni Bransford Madoka Takeuchi Jianjian Gong Martin Lefkowitz Milton Packer John JV McMurray | 2012 | The Lancet2012，，9851： | 2 |
| 4 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 5 | Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas 显示文摘 | Elisabeth Z Nancy W A Mark D W | 2002 | Cancer Res2002，62，： | 1 |
| 6 | Reproducibility of blood tests of liver fibrosis in clinical practice显示文摘 | Paul Calès Pascal Veillon Anselme Konaté Elisabeth Mathieu Catherine Ternisien Alain Chevailler Alban Godon Yves Gallois Fran?oise Joubaud Isabelle Hubert-Fouchard Frédéric Oberti Stéphane Réaud Gilles Hunault Fran?oise Mauriat Fran?oise Lunel-Fabiani | 2007 | Clinical Biochemistry2007，，1： | 1 |
| 7 | Isolation of mierasatellite loci in Sceloporus grammicus ( Squamata, Phrynosomatidae) 显示文摘 | Patrick H D Elisabeth A | 2004 | American J of Undergraduate Research2004，2，4： | 1 |
| 8 | A MYB Transcription Factor Regulates Very-Long-Chain Fatty Acid Biosynthesis for Activation of the Hypersensitive Cell Death Response in Arabidopsis(W)(OA)显示文摘 | Raffaele Sylvain Vailleau Fabienne Léger Amandine Joubès Jér?me Miersch Otto Huard Carine Blée Elisabeth Mongrand Sébastien Domergue Frédéric Roby Dominique | 2008 | Plant Cell2008，，3： | 1 |
| 9 | p rognostic factors in COPD patients receiving long2term oxygen therapy 显示文摘 | Monique M D Emnianuel M D Elisabeth Q | 1995 | Chest1995，107，5： | 1 |
| 10 | Gene expression after short periods of coronary occlusion显示文摘 | Elisabeth D Wolfgang S | 1998 | Mol Cell Bioch1998，186，1： | 1 |
| 11 | Typologies of crop-drought vulnerability: an empirical analysis of the socio-economic factors that influence the sensitivity and resilience to drought of three major food crops in China (1961-2001)显示文摘 | Simelton Elisabeth Fraser Evan D G Termansen MeRe | 2009 | Environmental Science and Policy2009，12，4： | 1 |
| 12 | Advanced sludge treatment affects extracellular polymeric substance to improve activated sludge dewatering显示文摘 | Elisabeth N Jan B Raf D H | 2004 | Hazardous Materials2004，106，： | 1 |
| 13 | IASLC/ATS/ERS INTERNATIONAL multidiscipli nary classification of lung adenocarcinoma 显示文摘 | William D Travis Elisabeth Brambilla Masayuki Noguchi | 2011 | Thorac On col2011，6，2： | 1 |
| 14 | Does origin of mycorrhizal fungus or mycorrhizal plant influence effectiveness of the mycorrhizal symbiosis显示文摘 | ELISABETH W M G A HERJDE V D KUYPER T W | 2001 | Plant and Soil2001，，230： | 1 |
| 15 | Mechanisms for pollutant transport between the boundary layer and the free troposphere 显示文摘 | Elisabeth A D Fish D J Dicks E M | 2001 | Journal of Geophysical Research2001，106，： | 1 |
| 16 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013，，9867： | 1 |
| 17 | Antinocicep-tive and anti-allodynic effects of oral PL37,a complete inhibitorof enkephalin-catabolizing enzymes,in a rat model of peripheralneuropathic pain induced by vincristine显示文摘 | THIBAULT K ELISABETH B SOPHIE D | 2008 | Eur J Pharmacol2008，600，13： | 1 |
| 18 | Biotransformation of vinclozolin in rat precision-cut liver slices: comparison with in vivo metabolic pattern 显示文摘 | Julian B Laurent D Elisabeth P | 2008 | J Agric Food Chem2008，56，： | 1 |
| 19 | Pvognostic factors in COPD patients receiving long term oxygen therapy显示文摘 | Monique M D Enmianue M D Elisabeth Q | 1995 | Chest1995，107，5： | 1 |
| 20 | Investigation of the corrosion behavior of carbon steel coated with fluoropolymer thin films 显示文摘 | Amel D Elisabeth G Yannick C | 2011 | Surface & Coatings Technology2011，205，： | 1 |
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