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| 1 | Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA显示文摘Objective:MicroRNA-21(miR-21)has been shown to be a key regulator of carcinogenesis.There were few reports about the comparison of serum miR-21 with conventional tumor markers.This study aimed to explore the diagnostic value of circulating miR-21 as a tumor marker in breast cancer(BC)and compare it with CA153 and carcinoembryonic antigen(CEA).Methods:Circulating miR-16 and miR-21 were amplified and quantitatively detected by real-time PCR in 89 BC patients and 55 healthy controls.The levels of CA153 and CEA were measured through electrochemiluminescence assays.Then the sensitivity in diagnosis of BC was compared among miR-21,CA153 and CEA.Results:The level of serum miR-21 was significantly higher in BC patients than controls(P<0.001).The sensitivity and specificity of miR-21 were 87.6%and 87.3%,respectively,whereas the sensitivities of CEA and CA153 were only 22.47%and 15.73%.Conclusions:Compared with CEA and CA153,serum miR-21 has a higher sensitivity in diagnosis of BC.Although not correlated with the status of ER,PR and clinical stages,serum miR-21 may be a potential diagnostic indicator for BC,especially for the early stage. | Jianjian Gao Qingyun Zhang Jianjun Xu Lijuan Guo Xuefeng Li | 2013 | Chinese Journal of Cancer Research2013，25，6： | 36 |
| 2 | Metal-organic framework derived CoSe2 nanoparticles anchored on carbon fibers as bifunctional electrocatalysts for efficient overall water splitting显示文摘发展有效,便宜,稳定,为切开的水的 non-noble-metal electrocatalysts,特别地能两个都催化氢进化反应的那些(她的) 在在阳极的阴极和氧进化反应(OER ) ,是挑战。我们开发了一个灵巧的方法因为综合从从容容宽敞 2 nanoparticles 一致地在碳纤维纸上抛锚了(经由热分解和 selenization 的从从容容宽敞 2/CF) 在 situ 成年 zeolitic imidazolate framework-67 (ZIF-67 ) 。从从容容宽敞 2/CF 在碱的答案在 HER 和 OER 显示出高、稳定的催化活动。在一个低房间潜力,即, 1.63 V,与二个从从容容宽敞 2/CF 电极装备的水 electrolyzer 给了 10 mAen 的切开水的水流 2007 并且 2014 年 10 月 21 日。我们然后与一个低级术语并且通过临床的描述的一篇详细摘要识别了 PAOD 的盒子。结果我们识别了 POAD 的 25 个盒子。大多数病人比 60 老 ? 年(84 ?%) 或有象血胆脂醇过多那样的另一个心血管的风险因素,钰 ? 钰吗?? | Chencheng Sun Qiuchun Dong Jun Yang Ziyang Dai Jianjian Lin Peng Chen Wei Huang Xiaochen Dong | 2016 | Nano Research2016，9，8： | 16 |
| 3 | Rare SNP Identified a TCP Transcription Factor Essential for Tendril Development in Cucumber显示文摘稀罕基因变体充满染色体,但是少些在染色体宽的协会学习易控制。这里,我们利用稀罕变化印射在黄瓜(Cucumis sativus L.) 为卷须开发发现基因必需品的策略。在里面许多 > 3000 根线,我们发现形成的一根唯一的卷须更少线分叉而不是卷须并且因此,失去它的爬的能力。我们假设了那这不平常的显型被一个稀罕变化引起并且随后识别了原因的单个核苷酸多型性。影响基因十编码一个 TCP 抄写因素在葫芦以内保存了并且在卷须明确地被表示,代表新机关身份基因。变化在对葫芦唯一的一个蛋白质主题以内发生并且作为 transcriptional 使活跃之物损害它的功能。从 near-isogenic 线的 transcriptomes 的分析识别了要求让卷须的能力察觉到并且爬支持的下游的基因。这研究提供一个例子在植物染色体探索稀罕功能的变体。 | Shenhao Wang Xueyong Yang Mengnan Xu Xingzhong Lin Tao Lin Jianjian Qi Guangjin Shao Nana Tian QingYang Zhonghua Zhang Sanwen Huang | 2015 | Molecular Plant2015，8，12： | 12 |
| 4 | 17β-estradiol contributes to the accumulationof myeloid-derived suppressor cells in bloodby promoting TNF-αsecretion显示文摘雌激素被影响有免疫力的房间的发展和激活强烈在有免疫力的回答处于性差别含有。最近的研究显示出那导出 myeloid 的 suppressor 房间(MDSC ) ,源于 CD11b + 在病理学的条件下面的 Gr-1 + myeloid 房间,在 modulating 免疫者回答起重要作用。然而,它仍然是未知的 MDSC 上的雌激素的效果。在现在的学习,我们在调整 MDSC 的累积上调查了雌激素的效果和机制。与有全身的豺狼座 erythematosus (SLE ) 的男病人相比,有 SLE 的女病人在浆液在外部血 mononuclear 房间和肿瘤坏死因素(TNF-) 的高水平显示出 MDSC 的更高的频率,这被发现。尤其是,在有 SLE 的女病人的浆液的 estradiol 水平断然与 MDSC 的频率被相关。而且, 17-estradiol 能支持 TNF -- 在由增加 CD11b + Gr-1 + 房间。而且, 17-estradiol 在 vivo 支持了 TNF- 的分泌物,它贡献了 CD11b + Gr-1 + 房间。另外,雌老鼠显示出 CD11b + Gr-1 + 房间和更高的 TNF- 比匹配年龄的雄的老鼠在血铺平。这些数据显示 17-estradiol 由支持 TNF- 分泌物在血贡献 MDSC 的累积,它增加 CD11b + Gr-1 + 房间。我们的调查结果在发炎和自体免疫的疾病的流行提供新卓见进性差别的机制。 | Guanjun Dong Ming You Hongye Fan Jianjian Ji Liang Ding Pengfei Li Yayi Hou | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 11 |
| 5 | Acquisition of deleterious mutations duringpotato polyploidization显示文摘Potatoes(Solanum tuberosum L.) represent an important tuber crop, worldwide. During its prolonged clonal propagation, numerous deleterious mutations have accumulated in the potato genome,leading to severe inbreeding depression; however,the shaping of this mutation burden during polyploidization and improvement is largely unknown.Here, we sequenced 20 diploid landraces of the Stenotomum group, eight tetraploid landraces, and 20 tetraploid modern cultivars, to analyze variations in their deleterious mutations. We show that deleterious mutations accumulated rapidly during the polyploidization of tetraploid potatoes. This study provides a foundation for future potato improvement. | Qun Lian Die Tang Zhiyan Bai Jianjian Qi Fei Lu Sanwen Huang Chunzhi Zhang | 2019 | Journal of Integrative Plant Biology2019，61，1： | 8 |
| 6 | Effect of shrub-grass vegetation coverage and slope gradient on runoff and sediment yield under simulated rainfall显示文摘Evaluating the benefits of sediment and runoff reduction in different vegetation types is essential for studying the mechanisms of soil and water conservation on the Loess Plateau.The experiment was conducted in shrub-grass plots with nine levels of mixed vegetation coverage from 0%to 70%,three slopes(10,15,and 20)and two rainfall intensities(1.0 and 2.5 mm/min).The results showed that the vegetation coverage and slope gradient significantly affect runoff and sediment yield.Shrub-grass vegetation coverage had a significant effect on the runoff start-time,runoff flow velocity,runoff rate,and soil erosion rate on hillslopes.Mixed vegetation coverage could effectively delay the runoff starttime and decrease the runoff flow velocity.However,the effects of the slope gradient on runoff and sediment yield are opposite to those of vegetation coverage.Shrub-grass vegetation coverage could effectively increase runoff and sediment yield reduction benefits,while their benefits were affected by the rainfall intensity.At the 1.0 mm/min rainfall intensity,the reduction in the sediment production rate was greater than that under the 2.5 mm/min intensity.However,when the shrub-grass vegetation coverage exceeded 42%,the runoff reduction benefit was more obvious at higher rainfall intensities.The cumulative sediment yield increased with increasing cumulative runoff,and the rate of increase in the cumulative runoff was greater than that of the cumulative sediment yield with increasing of shrub-grass vegetation coverage.Moreover,there was a power function relationship between cumulative sediment yield and cumulative runoff yield(P<0.05).Our paper is expected to provide a good reference on the ecological environment and vegetation construction on the Loess Plateau. | Dandan Han Jingcheng Deng Chaojun Gu Xingmin Mu Peng Gao Jianjian Gao | 2021 | International Journal of Sediment Research2021，36，1： | 8 |
| 7 | 校近期发表IF≥4.0的SCI论文摘要--Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population显示文摘 | Jin Guangfu Shu Yongqian Tian Tian Liang Jie Xu Yan Wang Furu Chen Jianjian Dai Juncheng Hu Zhibin Shen Hongbing Xu Lin | 2009 | 南京医科大学学报(自然科学版)2009，29，10： | 7 |
| 8 | Application of in vitro and in vivo models in the study of food allergy显示文摘Food allergy is one of the most important food safety problems that has attracted increasing attention.The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations.In this paper,we reviewed the common food allergy cell models including mast cell,basophil granulocyte and basophil,as well as the animal models of BALB/c mouse,C3H/HeJ mouse,and BN rat.We also introduced zebrafish,a promising model organism for investigating immunity though lacking direct applications in food allergy to date,and focused on traumatic inflammation,bacterial infection and viral infection models.In addition,we also summarized the clinical diagnostic research methods for food allergy.The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study,so as to support further investigations of food allergy. | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu | 2018 | Food Science and Human Wellness2018，7，4： | 7 |
| 9 | Challenges and Solutions of Information Security Issues in the Age of Big Data显示文摘Big data has been taken as a Chinese national strategy in order to satisfy the developments of the social and economic requirements and the development of new information technology. The prosperity of big data brings not only convenience to people's daily life and more opportunities to enterprises, but more challenges with information security as well. This paper has a research on new types and features of information security issues in the age of big data, and puts forward the solutions for the above issues: build up the big data security management platform, set up the establishment of information security system and implement relevant laws and regulations. | YANG Mengke ZHOU Xiaoguang ZENG Jianqiu XU Jianjian | 2016 | China Communications2016，13，3： | 6 |
| 10 | Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy显示文摘联合治疗是通常基于复杂 nanostructures 的利用,多重部件为 photothermal 作为相片热的精力变换器, photo-sensitizers,或剂量 intensifiers 工作的有希望的癌症治疗策略治疗(PTT ) ,光力学的治疗(太平洋夏季时间) ,或放射治疗(RT ) 。在这研究, ultrathin 钨氧化物 nanowires (W 18 O 49) 用一条 solvothermal 途径被综合并且作为多功能的 theranostic nanoplatform 检验了。在 vitro 并且在 vivo,分析证明这些 nanowires 能导致广泛的热 -- 并且汗衫在 980 nm 在附近下面的癌症房间的调停氧的损坏红外线(NIR ) 激光刺激。他们也被显示作为加强在放射治疗期间局部地并且有选择地提高放热精力免职的代理人的放射剂量工作。独自比作导致 NIR 的 PTT/PDT 和 RT, W 18 O 49-based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2???? ?? ?? 佦 ? 畳 ?? 猯扵￣?? | Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao Wenbo Bu | 2015 | Nano Research2015，8，11： | 5 |
| 11 | The Influence of Regional SSTs on the Interdecadal Shift of the East Asian Summer Monsoon显示文摘自从 1970 年代末,东亚经历了重要 interdecadal 气候移动。这移动被全球 SST 的一个十的变化伴随。以前的研究建议了全球 SST 背景地位的十的移动在如此的气候的移动起了一个实质的作用。然而,不同地区性的 SST 的单个角色仍然保持不清楚。在这研究,我们用一个大气的一般发行量模型,的整体实验调查了这些角色 GFDL (地球物理的液体动力学实验室) AM2。二种整体被执行。第一是模型与观察 climatological SST 在被驾驶的一个控制整体。第二是模型在分开的海洋区域与观察 climatological SST 正 interdecadal SST 背景移动在被驾驶的一个试验性的整体。结果建议在热带的 SST 移动在 extratropics 比那些施加了更重要的影响,尽管后者平常地贡献移动。夏天 monsoonal 发行量系统的变化包括南方亚洲人高度,向西和平的副热带的高度,和降低水平的空气流动,被分析。结果证明与热带以外的 SST 导致的那些比较,热带 SST 导致的移动忍受更多的类似到观察并且到模拟,全球 SST 规定了。特别地,在热带太平洋的观察 SST 移动,而非印度洋,自从 1970 年代,显著地作出贡献到东方亚洲夏天季风的移动。 | FU Jianjian LI Shuanglin | 2013 | Advances in Atmospheric Sciences2013，30，2： | 5 |
| 12 | The diffusive fluxes of inorganic nitrogen across the intertidal sediment-water interface of the Changjiang Estuary in China显示文摘Ammonium and nitrate concentrations were analyzed in near-bottom water and pore water collected from ten stations of the intertidal flat of the Changjiang Estuary during April, July, November and February. The magnitudes of the benthic exchange fluxes were determined on the basis of concentration gradients of ammonium and nitrate at the near-bottom water and interstitial water interface in combination with calculations of a modified Fick’s first law. Ammonium fluxes varied from-5.05 to 1.43 μg/(cm 2 ·d) and were greatly regulated by the production of ammonium in surface sediments, while nitrate fluxes ranged from-0.38 to 1.36 μg/(cm 2 ·d) and were dominated by nitrate concentrations in the tidal water. It was found that ammonium was mainly released from sediments into water columns at most of stations whereas nitrate was mostly diffused from overlying waters to intertidal sediments. In total, 823.75 t/a ammonium-N was passed from intertidal sediments to water while about 521.90 t/a nitrate-N was removed from overlying waters to intertidal sediments. This suggests that intertidal sediments had the significant influence on modulating inorganic nitrogen in the tidal water. | HOU Lijun LIU Min XU Shiyuan LU Jianjian OU Dongni YU Jie | 2006 | Acta Oceanologica Sinica2006，25，3： | 5 |
| 13 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 14 | MOF-derived molybdenum selenide on Ti_(3)C_(2)T_(x) with superior capacitive performance for lithium-ion capacitors显示文摘Two-dimensional Ti_(3)C_(2)T_(x) exhibits outstanding rate property and cycle performance in lithium-ion capacitors(LICs)due to its unique layered structure,excellent electronic conductivity,and high specific surface area.However,like graphene,Ti_(3)C_(2)T_(x) restacks during electrochemical cycling due to hydrogen bonding or van der Waals forces,leading to a decrease in the specific surface area and an increase in the diffusion distance of electrolyte ions between the interlayer of the material.Here,a transition metal selenide MoSe_(2) with a special three-stacked atomic layered structure,derived from metal-organic framework(MOF),is introduced into the Ti_(3)C_(2)T_(x) structure through a solvo-thermal method.The synergic effects of rapid Li+diffusion and pillaring effect from the MoSe_(2) and excellent conductivity from the Ti_(3)C_(2)T_(x) sheets endow the material with excellent electrochemical reaction kinetics and capacity.The composite Ti_(3)C_(2)T_(x)@MoSe_(2) material exhibits a high capacity over 300 mAh·g^(-1) at 150 mA·g^(-1) and excellent rate property with a specific capacity of 150 mAh·g^(-1) at 1500 mA·g^(-1).Addition-ally,the material shows a superior capacitive contribution of 86.0%at 2.0 mV·s^(-1) due to the fast electrochemical reactions.A Ti_(3)C_(2)T_(x)@MoSe_(2)//AC LIC device is also fabricated and exhibits stable cycle performance. | Jianjian Zhong Lu Qin Jianling Li Zhe Yang Kai Yang Mingjie Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，5： | 4 |
| 15 | Trans-regional transmission of large-scale hydropower: problems and solutions in receiving power grid显示文摘Large-capacity hydropower transmission from southwestern China to load centers via ultra-high voltage direct current(UHVDC) or ultra-high voltage alternating current(UHVAC) transmission lines is an important measure of the accommodation of large-scale hydropower in China. The East China Grid(ECG) is the main hydropower receiver of the west–east power transmission channel in China. Moreover, it has been subject to a rapidly increasing rate of hydropower integration over the past decade. Currently, large-scale outer hydropower is one of the primary ECG power sources. However, the integration of rapidly increasing outer hydropower into the power grid is subject to a series of severe drawbacks. Therefore, this study considered the load demands and hydropower transmission characteristics for the analysis of several major problems and the determination of appropriate solutions. The power supply-demand balance problem, hydropower transmission schedule problem, and peakshaving problem were considered in this study. Correspondingly, three solutions are suggested in this paper, which include coordination between the outer hydropower and local power sources, an inter-provincial power complementary operation, and the introduction of a market mechanism. The findings of this study can serve as a basis to ensure that the ECG effectively receives an increased amount of outer hydropower in the future. | Jianyu Lu Jianjian Shen Chengguo Su Qianqian Shen | 2019 | Global Energy Interconnection2019，2，4： | 4 |
| 16 | Seasonal dependency of controlling factors on the phytoplankton production in Taihu Lake, China显示文摘In this study, 44 profiles of gross primary productivity(GPP) and sunlight, along with water temperature, Chlorophyll-a(Chla) and nutrients, were observed in Meiliang Bay of Taihu Lake, China, in the spring, summer, and fall seasons. Effects of water temperature, light,and nutrient concentration were examined in relation to the GPP-unit-Chla(GPP of algae per Chla). The results showed that the optimum temperature for the GPP of phytoplankton was 27.9°C, the optimal PNA-unit-Chla(photon number absorbed by phytoplankton per Chla) was 0.25(mol), and the HSCN-unit-Chla and HSCP-unit-Chla(half-saturation constants of nitrogen and phosphorus of algae per Chla) were 0.005(mg/L) and 0.0004(mg/L), respectively. The seasonal dependency of the effect of different factors on the GPP was analyzed. Compared with temperature and nutrients, light was found to be the most important factor affecting the GPP during the three seasons. The effect of temperature and nutrients on the GPP of phytoplankton has obvious seasonal change. In spring, temperature was the secondary factor affecting the GPP of phytoplankton, and the effect of nutrients may be negligible in the eutrophic lake on account of temperature limit, which showed that the GPP of algae was only affected by the physical process. In summer and fall, temperature didn't affect the GPP of algae, and the presence of nutrients was the secondary factor affecting the GPP of phytoplankton. From summer to fall, effect of phosphorus was weakened and effect of nitrogen was enhanced. | Qiaohua Zhao Jing Wang Jianjian Wang Julian X.L.Wang | 2019 | Journal of Environmental Sciences2019，31，2： | 4 |
| 17 | An Aware-Scheduling Security Architecture with Priority-Equal Multi-Controller for SDN显示文摘Current SDN controllers suffer from a series of potential attacks. For example, malicious flow rules may lead to system disorder by introducing unexpected flow entries. In this paper, we propose Mcad-SA, an aware decision-making security architecture with multiple controllers, which could coordinate heterogeneous controllers internally as a 'big' controller. This architecture includes an additional plane, the scheduling plane, which consists of transponder, sensor, decider and scheduler. Meanwhile it achieves the functions of communicating, supervising and scheduling between data and control plane. In this framework, we adopt the vote results from the majority of controllers to determine valid flow rules distributed to switches. Besides, an aware dynamic scheduling(ADS) mechanism is devised in scheduler to intensify security of Mcad-SA further. Combined with perception, ADS takes advantage of heterogeneity and redundancy of controllers to enable the control plane operate in a dynamic, reliable and unsteady state, which results in significant difficulty of probing systems and executing attacks. Simulation results demonstrate the proposed methods indicate better security resilience over traditional architectures as they have lower failure probability when facing attacks. | Chao Qi Jiangxing Wu Guozhen Cheng Jianjian Ai Shuo Zhao | 2017 | China Communications2017，14，9： | 4 |
| 18 | Identification and characterization of two human immunodeficiency virus type 1 unique recombinant forms from Yunnan, China显示文摘Dear Editor,Recombination contributes greatly to the diversity of human immunodeficiency virus type 1(HIV-1).A large number of recombinant strains have been found in China,particularly in Yunnan,which is considered the HIV-1 epicenter of China.Surveillance of unique recombinant forms is helpful for prediction of new circulating recombinant forms.In this study,we identified two | Jianjian Li Lin Li Shaomin Yang Jingyun Li Mi Zhang Cuixian Yang Jiafa Liu Huiqin Li | 2016 | Virologica Sinica2016，31，2： | 4 |
| 19 | Online Teaching for Elementary and Secondary Schools During COVID-19显示文摘This report draws on data from two articles published by the Center for Teacher Education Research of Beijing Normal University,namely,“Survey Report on the Status Quo of Online Teaching and Related Needs Among Elementary and Secondary Schools During COVID-19 Prevention and Control:Based on a Sample Survey on School Principals in China”and“Survey Report on the Status Quo of Online Teaching and Related Needs Among Elementary and Secondary School Teachers During COVID-19 Prevention and Control:Based on a Sample Survey on Teachers in China.” | Huan Song Jianjian Wu Tianyi Zhi | 2020 | ECNU Review of Education2020，3，4： | 3 |
| 20 | Novel benzenediamine derivative FC99 ameliorates zymosan-induced arthritis by inhibiting RORγt expression and Thl7 cell differentiation显示文摘 | Jianjian Ji Huan Dou Xiaoqin Li Yuxian Song Xiaojing Li Erguang Li Renxiang Tan Yayi Hou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 3 |
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