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| 1 | Serum bicarbonate may independently predict acute kidney injury in critically ill patients:An observational study显示文摘AIM: To explore whether serum bicarbonate at admission to intensive care unit(ICU) predicted development of acute kidney injury(AKI).METHODS:We studied all patients admitted to our ICU over a 2 year period(February 2010 to 2012).The ICU has a case mix of medical and surgical patients excluding cardiac surgical,trauma and neurosurgical patients.We analysed 2035 consecutive patients admitted to ICU during the study period.Data were collected by two investigators independently and in duplicate using a standardised spread sheet to ensure accuracy.Ambiguous data were checked for accuracy where indicated.AKI was defined using the Kidney Disease Improving Global Outcomes criteria.Patients were divided into two groups;patients who developed AKI or those who did not,in order to compare the baseline characteristics,and laboratory and physiologic data of the two cohorts.Regression analysis was used to identify if serum bicarbonate on admission predicted the development of AKI.RESULTS:Of 2036 patients 152(7.5%)were excluded due to missing data.AKI developed in 43.1%of the patients.The AKI group,compared to the nonAKI group,was sicker based on their lower systolic,diastolic and mean arterial pressures and a higher acutephysiology and chronic health evaluation(APACHE)Ⅲand SAPSⅡscores.Moreover,patients who developed AKI had more co-morbidities and a higher proportion of patients who developed AKI required mechanical ventilation.The multi-regression analysis of independent variables showed that serum bicarbonate on admission(OR=0.821;95%CI:0.796-0.846;P<0.0001),APACHEⅢ(OR=1.011;95%CI:1.007-1.015;P<0.0001),age(OR=1.016;95%CI:1.008-1.024;P<0.0001)and presence of sepsis at ICU admission(OR=2.819;95%CI:2.122-23.744;P=0.004)were each significant independent predictors of AKI.The area under the ROC curve was 0.8(95%CI:0.78-0.83),thereby demonstrating that the predictive model has relatively good discriminating power for predicting AKI.CONCLUSION:Serum bicarbonate on admission may independently be used to make a diagnosis of AKI. | Anuksha Gujadhur Ravindranath Tiruvoipati Elizabeth Cole Saada Malouf Erum Sahid Ansari Kim Wong | 2015 | World Journal of Critical Care Medicine2015，4，1： | 3 |
| 2 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 3 | Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast显示文摘 | Dmitry K. Pokholok Christopher T. Harbison Stuart Levine Megan Cole Nancy M. Hannett Tong Ihn Lee George W. Bell Kimberly Walker P. Alex Rolfe Elizabeth Herbolsheimer Julia Zeitlinger Fran Lewitter David K. Gifford Richard A. Young | 2005 | Cell2005，，4： | 1 |
| 4 | Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials显示文摘 | Tomasz Zaremba Huw Thomas Michael Cole Elizabeth R. Plummer Nicola J. Curtin | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 5 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology Immunotherapy2009，，1： | 1 |
| 6 | Comparison of Quality-of-Life Instruments in Adults with Strabismus显示文摘 | Sarah R. Hatt David A. Leske Elizabeth A. Bradley Stephen R. Cole Jonathan M. Holmes | 2009 | American Journal of Ophthalmology2009，，4： | 1 |
| 7 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology, Immunotherapy2009，，1： | 1 |
| 8 | Antimicrobial susceptibility and multi-drug resistance of Salmonella enterica subspecies enterica serovars in Sudan显示文摘 | Mayha Mohammed Ali Nor Elmadiena Adil Ali Hussein Catherine Anne Muckle Linda Cole Elizabeth Wilkie Ketna Mistry Ann Perets | 2013 | Tropical Animal Health and Production2013，，5： | 1 |
| 9 | Frequency sensitivity and directional hearing in the gleaning bat,Plecotus auritus (Linnaeus 1758)显示文摘 | Roger B. Coles Anna Guppy M. Elizabeth Anderson P. Schlegel | 1989 | Journal of Comparative Physiology A1989，，2： | 1 |
| 10 | Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast显示文摘 | Dmitry K. Pokholok Christopher T. Harbison Stuart Levine Megan Cole Nancy M. Hannett Tong Ihn Lee George W. Bell Kimberly Walker P. Alex Rolfe Elizabeth Herbolsheimer Julia Zeitlinger Fran Lewitter David K. Gifford Richard A. Young | 2005 | Cell2005，，4： | 1 |
| 11 | Mindfulness-Based Stress Reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial显示文摘 | J. David Creswell Michael R. Irwin Lisa J. Burklund Matthew D. Lieberman Jesusa M.G. Arevalo Jeffrey Ma Elizabeth Crabb Breen Steven W. Cole | 2012 | Brain Behavior and Immunity2012，，7： | 1 |
| 12 | Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy显示文摘 | C. Marcela Diaz-Montero Mohamed Labib Salem Michael I. Nishimura Elizabeth Garrett-Mayer David J. Cole Alberto J. Montero | 2009 | Cancer Immunology Immunotherapy2009，，1： | 1 |
| 13 | Blood Gases and Retinopathy of Prematurity: The ELGAN Study显示文摘 | Hauspurg Alisse K Allred Elizabeth N Vanderveen Deborah K Chen Minghua Bednarek Francis J Cole Cynthia Ehrenkranz Richard A Leviton Alan Dammann Olaf | 2011 | Neonatology2011，，： | 1 |
| 14 | 比萨为人民显示文摘迈克尔 拉斯托里亚(Michael Lastoria)是总部位于华盛顿哥伦比亚特区(以下简称华盛顿)的连锁快餐品牌&Pizza的首席执行官,该品牌在东海岸沿线开设了36家连锁店。拉斯托里亚又高又瘦,看起来很安静,留着络腮胡和一头棕色的过肩长发。一个温暖的春日,我在曼哈顿诺马德区的一家&Pizza餐厅里见到了他,当时,他上身穿着一件黑色丝绸衬衫,披着一条黑色披风,下身穿着黑色短裤,搭配一双黑色长袜,脚蹬黑色Wu Wear牌袋鼠靴:如果他穿着这一身走在山本耀司(Yohji Yamamoto)的时装秀上,看起来可能就是耶稣的样子吧。 | Elizabeth Dunn Cole Wilson(摄影) 杨飞(译) | 2019 | 商业周刊(中文版)2019，0，21： | 0 |
| 15 | 提交后更改预先制订的统计分析计划 这些计划是研究完整性的基础,但不是不可改变的显示文摘透明度和可重复性是证据生成和研究知识传播的两个基本原则1-2。研究人员提出问题,挑战结论,复制结果并仔细审查结果——这就是我们积累知识并帮助制订循证政策的方式。如果科学研究要作为能够对人类福祉产生重大影响的政策基础,科学的完整性、可靠性、可重复性和透明度至关重要3。 | Islam Nazrul Cole Tim J Ross Joseph S Feeney Timothy Loder Elizabeth 吴俣(译) 刘民(校) | 2022 | 英国医学杂志中文版2022，25，12： | 0 |
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