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| 1 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 3 | 血管紧张素受体阻断剂预防男性人群痴呆发生风险研究:前瞻性队列分析(摘要)显示文摘目的探讨血管紧张素受体拮抗剂能否预防阿尔茨海默病和老年痴呆症,或同时减少两种疾病的进展。
设计前瞻性队列分析。
资料来源2002—2006年美国退伍军人数据库。 | Nien-Chen Li Austin Lee Rachel A Whitmer Miia Kivipelto Elizabeth Lawler Lewis E Kazis Benjamin Wolozin 夏曙(译) 于世英(校) | 2010 | 英国医学杂志中文版2010，13，2： | 5 |
| 4 | 东南亚地区五加科植物进化关系的初步研究(英文)显示文摘东南亚五加科包含14个属约500种,本文应用ITS片段对该区五加科植物的进化关系作了初步研究。研究显示该地区五加科植物具有复杂的起源,很多属属于亚洲掌状复叶类群或Hedereae族的一支中。该区特有类群Harmsiopanax形态上非常特殊,但其系统位置尚未不明朗。在Brassaiopsis属中,有几种形态差异较大的种,但它们属同一单系,加之各种间ITS序列差异较小,故应是新近起源于马来亚半岛和苏门达腊岛的种类。Wardenia simplex聚类在Brassaiopsis一支中,故不支持将Wardenia作为独立的属。东南亚地区对于Schefflera属的发育非常重要,已有的证据显示该区的Schefflera属植物属于该属的Heptapleurum类群。马来亚与泰国南部的Dendropanax lancifolius并没有与Dendropanax属的核心类群聚在一起,其系统地位需进一步研究。Macropanax maingayi是非常特殊的一个种,曾被独立分出,成立了单种属Hederopsis。本文的分析清楚表明它属于Macropanax属。Aralia merrillii因为其不同寻常的攀缘特性而被独立出来,建立了单种属Acanthophora,但ITS序列分析支持将它置于Aralia属中。新增的取样继续支持Arthrophyllum的单系性。Os-moxylon的原初分布范围在东南亚,它是五加科系统进化树上孤立的类群。 | 文军 朱昱苹 Chunghee LEE Elizabeth WIDJAJA LENG Guan Saw | 2008 | 云南植物研究2008，30，4： | 5 |
| 5 | Maintenance Peginterferon Therapy and Other Factors Associated With Hepatocellular Carcinoma in Patients With Advanced Hepatitis C显示文摘 | Anna S. Lok James E. Everhart Elizabeth C. Wright Adrian M. Di Bisceglie Hae–Young Kim Richard K. Sterling Gregory T. Everson Karen L. Lindsay William M. Lee Herbert L. Bonkovsky Jules L. Dienstag Marc G. Ghany Chihiro Morishima Timothy R. Morgan | 2011 | Gastroenterology2011，，3： | 4 |
| 6 | Cardiorenal biomarkers in acute heart failure显示文摘与心失败(HF ) 管理病人是在肾的功能能极大地增加的变得更坏联系的本身,而是存在以内的一项挑战性的任务死亡和病态。早诊断和治疗是钥匙阻止再进医院和还原剂保健费用。Biomarkers 长在与 HF 诊断和预言的病人作为高度敏感、特定的工具被建立了。思考不同 pathophysiological 事件和进行中的细胞的侮辱, biomarkers 被证明优异到常规实验室测试。更好的试金和快速的分析的可获得性作为紧急情况部门并且在病人的床边的 point-of-care 测试允许 biomarkers 的使用。尖锐 HF 病人经常继续发展变得更坏肾的功能,称为的同样尖锐的 cardiorenal 症候群。研究的成长宽度显示出联合多重 biomarkers 更好制定结果并且在如此的病人生产理想的结果的含意。 | Rajiv Choudhary Dipika Gopal Ben A. Kipper Alejandro De La Parra Landa Hermineh Aramin Elizabeth Lee Saloni Shah Alan S. Maisel | 2012 | Journal of Geriatric Cardiology2012，9，3： | 4 |
| 7 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 8 | Molecular Characterization of the Calvin Cycle Enzyme Phosphoribulokinase in the Stramenopile Alga Vaucheria litorea and the Plastid Hosting Mollusc Elysia chlorotica显示文摘Phosphoribulokinase (PRK ) ,一个原子编码对光合的碳减小(加尔文) 唯一的质体局部性的酶周期,从 stramenopile 水藻 Vaucheria litorea 被克隆并且描绘。这水藻是为软体动物(海蛞蝓) 的质体的来源使动物能完全由 photoautotrophic CO2 幸存月的 Elysia chlorotica 固定。1633-bp V。litorea prk 基因被克隆并且编码区域,发现被四 introns 打断,编码 405-amino 酸蛋白质。这蛋白质包含被指导到建筑群的原子编码蛋白质期望的典型由两部组成的目标顺序(即四膜界限) 海藻的质体。PRK 和酶活动的 De novo 合成在 E 被检测。尽管有 V 被饿了的 chlorotica。为几个月的 litorea。不同于海藻的酶,在海蛞蝓的 PRK 没展出氧化还原作用规定。部分编码 PRK 基因的二个拷贝用 PCR 从两海蛞蝓和 aposymbiotic 海蛞蝓鸡蛋 DNA 被孤立。每个拷贝包含跨越 exon 的核苷酸区域 1 并且 exon 的部分 2 V。litorea prk,包括由两部组成的指向肽。然而,更大的 prk 碎片也包括 intron 1。在 E 的 prk 的 exon 和 intron 序列。chlorotica 和 V。litorea 是将近相同的。这些数据建议 PRK 是在 V 调整的差别。litorea 和 E。chlorotica 和 V 的至少部分。litorea 原子 PRK 基因在被饿几个月了的海蛞蝓是在场的。 | Mary E. Rumpho Sirisha Pochareddy Jared M. Worful Elizabeth J. Summer Debashish Bhattacharya Karen N. Pelletreau Mary S. Tyler Jungho Lee James R. Manhart Kara M. Soule | 2009 | Molecular Plant2009，2，6： | 3 |
| 9 | Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC显示文摘 | Diego F. Calvisi Sara Ladu Alexis Gorden Miriam Farina Elizabeth A. Conner Ju–Seog Lee Valentina M. Factor Snorri S. Thorgeirsson | 2006 | Gastroenterology2006，，4： | 3 |
| 10 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 11 | 以美国交通为例分析高速铁路二氧化碳减排潜力(译文)显示文摘美国已着手对一项新项目进行投资,即城际高速铁路系统,联邦基金投入80亿美元的头期款。高速铁路项目旨在提供就业机会,支援经济发展,为经济竞争力奠定基础,支持互联宜居社区,提高能源效率,改善环境质量。在本论文中,我们研究了高速铁路预期能源和环境效益的一个具体方面:对比持续依赖汽车和航空模式的城际旅行,分析二氧化碳减排潜力。通过预测2050年的美国旅行,以及从欧洲(基于美国的预测)获得的向高铁转变的经验,我们为美国高速铁路提出方案,解释旅行中交通工具,燃料,二氧化碳排放的改变,并基于对未来旅行条件和水平的两种预测,对2050年有竞争的汽车和航空模式需求水平做出解释。一种方案假设趋势会扩展,另一种方案假设为绿色革命,其为相当低水平的旅行及排放量。我们可以得出结论,即在任何一种方案下,与无高速铁路的原方案对比,高速铁路将在交通方面少量(约1%)减少二氧化碳排放。二氧化碳排放量只能少量降低的主要原因是在由高速铁路连接的主要地铁区域和转向高速铁路的范围内旅行所占的份额很少。 | 涂海 Andrew Kosinski Lee Schipper Elizabeth Deakin | 2012 | 科技视界2012，，9： | 2 |
| 12 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 13 | Des-γ-Carboxy Prothrombin and α-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma显示文摘 | Anna S. Lok Richard K. Sterling James E. Everhart Elizabeth C. Wright John C. Hoefs Adrian M. Di Bisceglie Timothy R. Morgan Hae–Young Kim William M. Lee Herbert L. Bonkovsky Jules L. Dienstag | 2010 | Gastroenterology2010，，2： | 2 |
| 14 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 15 | Lessonplanning guidelines for student teachers: Ascaffold for the development of pedagogicalcontent knowledge 显示文摘 | Lee Rusznyak & Elizabeth Woalton | 2011 | education aschange2011，15，2： | 1 |
| 16 | The death effector domain protein family显示文摘 | Bryan C Barnhart Justine C Lee Elizabeth C Alappat | 2003 | Oncogene2003，22，53： | 1 |
| 17 | Circulating Resistin Levels Are Not Associated with Obesity or Insulin Resistance in Humans and Are Not Regulated by Fasting or Leptin Administration: Cross-Sectional and Interventional Studies in Normal, Insulin-Resistant, and Diabetic Subjects显示文摘 | Jennifer H. Lee Jean L. Chan Nikos Yiannakouris Meropi Kontogianni Elizabeth Estrada Richard Seip Christine Orlova Christos S. Mantzoros | 2003 | The Journal of Clinical Endocrinology & Metabolism2003，，10： | 1 |
| 18 | Seizures induced by intracerebral injection of thrombin: a model of intracerebral hemorrhage显示文摘 | Kevin R Lee Ivo Drury Elizabeth Vitarbo | | 0，，： | 1 |
| 19 | Scalability study of the ad hoc on - demand distance vector routing protocol 显示文摘 | Sung Ju Lee Elizabeth M R Charles E P | 2003 | Wiley International Journal of Network Management2003，13，2： | 1 |
| 20 | Serum alpha-fetoprotein levels in patients with advanced hepatitis C: Results from the HALT-C Trial显示文摘 | Adrian M. Di Bisceglie Richard K. Sterling Raymond T. Chung James E. Everhart Jules L. Dienstag Herbert L. Bonkovsky Elizabeth C. Wright Gregory T. Everson Karen L. Lindsay Anna S.F. Lok William M. Lee Timothy R. Morgan Marc G. Ghany David R. Gretch the H | 2005 | Journal of Hepatology2005，，3： | 1 |
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