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| 1 | Metalloproteinase expression after desflurane preconditioning in hepatectomies:A randomized clinical trial显示文摘BACKGROUND Hepatectomy with inflow occlusion results in ischemia-reperfusion injury;however,pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients.The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases,which may signal pathologic hepatic tissue reformation.AIM To investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.METHODS This is a single-center,prospective,randomized controlled trial conducted at the 4th Department of Surgery of the Medical School of Aristotle University of Thessaloniki,between August 2016 and December 2017.Forty-six patients were randomized to either the desflurane treatment group for pharmacological preconditioning(by replacement of propofol with desflurane,administered 30 min before induction of ischemia)or the control group for standard intravenous propofol.The primary endpoint of expression levels of matrix metalloproteinases and their inhibitors was determined preoperatively and at 30 min posthepatic reperfusion.The secondary endpoints of neutrophil infiltration,coagulation profile,activity of antithrombin III(AT III),protein C(PC),protein S and biochemical markers of liver function were determined for 5 d postoperatively and compared between the groups.RESULTS The desflurane treatment group showed significantly increased levels of tissue inhibitor of metalloproteinases 1 and 2,significantly decreased levels of matrix metalloproteinases 2 and 9,decreased neutrophil infiltration,and less profound changes in the coagulation profile.During the 5-d postoperative period,all patients showed significantly decreased activity of AT III,PC and protein S(vs baseline values,P<0.05).The activity of AT III and PC differed significantly between the two groups from postoperative day 1 to postoperative day 5(P<0.05),showing a moderate drop in activity of AT III and PC in the desflurane treatment group and a dramatic drop in the control group.Compared to the control group,the desflurane treatment group also had significantly lower international normalized ratio values on all postoperative days(P<0.005)and lower serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase values on postoperative days 2 and 3(P<0.05).Total length of stay was significantly less in the desflurane group(P=0.009).CONCLUSION Desflurane preconditioning can lessen the inflammatory response related to ischemia-reperfusion injury and may shorten length of hospitalization. | Eleni Koraki Ioannis Mantzoros Christos Chatzakis Anna Gkiouliava Angeliki Cheva Athina Lavrentieva Freideriki Sifaki Helena Argiriadou Isaak Kesisoglou Konstantinos Galanos-Demiris Stefanos Bitsianis Konstantinos Tsalis | 2020 | World Journal of Hepatology2020，12，11： | 4 |
| 2 | Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case–control study显示文摘 | Maria Dalamaga Ilias Migdalis Jessica L. Fargnoli Evangelia Papadavid Erica Bloom Nicholas Mitsiades Konstantinos Karmaniolas Nicolaos Pelecanos Sofia Tseleni-Balafouta Amalia Dionyssiou-Asteriou Christos S. Mantzoros | 2009 | Cancer Causes & Control2009，，5： | 3 |
| 3 | Midgut neuroendocrine tumor presenting with acute intestinal ischemia显示文摘Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment. | Ioannis Mantzoros Natalia Antigoni Savvala Orestis Ioannidis Styliani Parpoudi Lydia Loutzidou Despoina Kyriakidou Angeliki Cheva Vasileios Intzos Konstantinos Tsalis | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 4 | Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer显示文摘 | Spyros P. Gialamas Eleni Th. Petridou Sofia Tseleni-Balafouta Themistoklis N. Spyridopoulos Ioannis L. Matsoukis Agathi Kondi-Pafiti George Zografos Christos S. Mantzoros | 2011 | Metabolism2011，，11： | 2 |
| 5 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 6 | The Role of Adiponectin in Cancer: A Review of Current Evidence显示文摘 | Maria Dalamaga Kalliope N. Diakopoulos Christos S. Mantzoros | 2012 | Endocrine Reviews2012，，4： | 2 |
| 7 | Metformin and Sulfonylureas in Relation to Cancer Risk in Type II Diabetes Patients: A Meta-analysis using primary data of published studies显示文摘 | Bindiya Thakkar Konstantinos N. Aronis Maria T. Vamvini Kelsey Shields Christos S. Mantzoros | 2013 | Metabolism2013，，7： | 2 |
| 8 | Leptin in relation to growth and developmental processes in the fetus显示文摘 | Christou H Serdy S Mantzoros CS | 2002 | Sesmin Reprod Med2002，20，2： | 1 |
| 9 | Diabetes and risk of endometrial cancer:a population based prospective cohort study显示文摘 | Friberg E Mantzoros CS Wolk A | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，2： | 1 |
| 10 | Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines显示文摘 | Hyun-Seuk Moon Fadime Dincer Christos S. Mantzoros | 2013 | Metabolism2013，，8： | 1 |
| 11 | Plasma adiponectin coneentrations in relation to endometrial cancer: a ease-control study in Greece 显示文摘 | Petridou E Mantzoros C Dessypris N | 2003 | J Clin Endoerinol Metab2003，88，3： | 1 |
| 12 | Adiponectin in insulin resist- ance: lessons from translational research 显示文摘 | Ziemke F Mantzoros CS | 2010 | Am J Clin Nutr2010，91，1： | 1 |
| 13 | Diabetes mellitus and risk of endometrial cancer:a meta-analysis显示文摘 | Friberg E Orsini N Mantzoros CS | 2007 | Diabetologia2007，50，7： | 1 |
| 14 | The role of leptin in human obesity and disease; a review of current evidence显示文摘 | Mantzoros CS | 1999 | Ann Intern Med1999，130，8： | 1 |
| 15 | Circulating adipo-neetin levels are associated with better glyeernie control, more favorable liquid profile, and reduced inflammation in women with type 2 diabetes显示文摘 | Mantzoros CS Li T Mansn JE | 2005 | Clin Eedocrinol Metab2005，90，： | 1 |
| 16 | Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: A 5-year cohort study显示文摘 | Tsiodras S Mantzoros C Hammer S | 2000 | Arch Intern Med2000，160，： | 1 |
| 17 | From leptin to other adipokines inheahh and disease: facts and expectations at the beginning of the 21 st century 显示文摘 | Bluher M Mantzoros CS | 2015 | Metabolism2015，64，： | 1 |
| 18 | Cancer anorexia-cachexia syndrome:are neurpetides the keys显示文摘 | Mantzoros CS Bolhke K Inui A | 1999 | Cancer Res1999，59，18： | 1 |
| 19 | Circulating adiponectinlevels are associated with better glycemic control,more favorablelipid profile,and reduced inflammation in women with type 2 dia-betes显示文摘 | Mantzoros CS Li T Manson JE | 2005 | J Clin Endocrinol Metab2005，90，8： | 1 |
| 20 | Adiponectin in insulin resistance: lessons from translational research显示文摘 | Zielnke F Mantzoros CS | 2010 | Am J Clin Nutr2010，91，： | 1 |
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