|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Disassembly of the fruit cell wall by the ripening-associated polygalacturonase and expansin influences tomato cracking显示文摘Fruit cracking is an important problem in horticultural crop production.Polygalacturonase(SlPG)and expansin(SlEXP1)proteins cooperatively disassemble the polysaccharide network of tomato fruit cell walls during ripening and thereby,enable softening.A Golden 2-like(GLK2)transcription factor,SlGLK2 regulates unripe fruit chloroplast development and results in elevated soluble solids and carotenoids in ripe fruit.To determine whether SlPG,SlEXP1,or SlGLK2 influence the rate of tomato fruit cracking,the incidence of fruit epidermal cracking was compared between wild-type,Ailsa Craig(WT)and fruit with suppressed SlPG and SlEXP1 expression(pg/exp)or expressing a truncated nonfunctional Slglk2(glk2).Treating plants with exogenous ABA increases xylemic flow into fruit.Our results showed that ABA treatment of tomato plants greatly increased cracking of fruit from WT and glk2 mutant,but not from pg/exp genotypes.The pg/exp fruit were firmer,had higher total soluble solids,denser cell walls and thicker cuticles than fruit of the other genotypes.Fruit from the ABA treated pg/exp fruit had cell walls with less water-soluble and more ionically and covalently-bound pectins than fruit from the other lines,demonstrating that ripening-related disassembly of the fruit cell wall,but not elimination of SlGLK2,influences cracking.Cracking incidence was significantly correlated with cell wall and wax thickness,and the content of cell wall protopectin and cellulose,but not with Ca^(2+)content. | Fangling Jiang Alfonso Lopez Shinjae Jeon Sergio Tonetto de Freitas Qinghui Yu Zhen Wu John M.Labavitch Shengke Tian Ann L.T.Powell Elizabeth Mitcham | 2019 | Horticulture Research2019，6，1： | 13 |
| 2 | Expansion of China's free antiretroviral treatment program显示文摘 | ZHAO De-cai WEN Yi MA Ye ZHAO Yan ZHANG Yao WU Ya-song LIU Xia Elizabeth Au LIU Zhong-fu ZHANG Fu-jie | 2012 | Chinese Medical Journal2012，，19： | 7 |
| 3 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 4 | Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder:a three-month observational study显示文摘背景痛苦的物理症状( PPS )可以作为专业的一个部件介绍在中国病人的 .Their 效果一直不是的压抑的混乱( MDD ) investigated.This 分析在疾病严厉报导变化,治疗模式,在一个中国队的生活和结果的质量根据存在(PPS+)或痛苦的物理 symptoms.Methods 的缺席(PPS-),从来自中国的亚洲国家和区域的病人的大观察3月的研究的中国病人的亚群是 classi 49.56 (26.49 ) 为 PPS- 的 vs.16.60 (20.99 ) , P 0.01 ) ,更多被压抑(HAMD17,平均数(SD ) :25.32 (5.47 ) 为 PPS- 的 vs.23.33 (5.24 ) , P=0.002 ) 并且生活的有的更差的质量(EQ-5D 健康状态,平均数(SD ) :38.48 (22.38 ) 为 PPS- 的 vs.49.57 (18.54 ) , P 0.001 ).PPS+ 病人在压抑的症状严厉显示出更少的全面改进(HAMD17,从基线(95% CI ) 的变化:-17.38(-18.65,-16.12) vs.-19.20 (为 PPS- 的 -20.05,-18.35) , P=-0.032;CGI-S,从基线(95% CI ) 变化:-2.85(-3.11,-2.58) vs.-3.20 (为 PPS- 的 -3.38,-3.02) , P=0.044 ).Conclusions PPS 比与当抗抑郁剂被给时,比 PPS- 与更大的 MDD 严厉和更少的改进联系的亚洲 populations.PPS+were 的以前的研究相比期望是不太经常的。 | LI Hui-chun ZHANG Ming-yuan WANG Gang ZHANG Hong-geng ZHANG Hong-yan LIU Ying LI Ming ZHANG Cong-pei TANG Ji-sheng WU Wen-yuan Pritibha Singh Renee Elizabeth Granger Joel Raskin ANG Qiu-qing | 2010 | Chinese Medical Journal2010，，15： | 5 |
| 5 | The Genomes of the Allohexaploid Echinochloa crus-galli and Its Progenitors Provide Insights into Polyploidization-Driven Adaptation显示文摘The hexaploid species Echinochloa crus-galli is one of the most detrimental weeds in crop fields,especially in rice paddies.Its evolutionary history is similar to that of bread wheat,arising through polyploidization after hybridization between a tetraploid and a diploid species.In this study,we generated and analyzed high-quality genome sequences of diploid(E.haploclada),tetraploid(E.oryzicola),and hexaploid(E.crus-galli)Echinochloa species.Gene family analysis showed a significant loss of disease-resistance genes such as those encoding NB-ARC domain-containing proteins during Echinochloa polyploidization,contrary to their significant expansionduring wheat polyploidization,suggesting that natural selection might favor reduced investment in resistance in this weed to maximize its growth and reproduction.In contrast to the asymmetric patterns of genome evolution observed in wheat and other crops,no significant differences in selection pressure were detected between the subgenomes in E.oryzicola and E.crus-galli.In addition,distinctive differences in subgenome transcriptome dynamics during hexaploidization were observed between E.crus-galli and bread wheat.Collectively,our study documents genomic mechanisms underlying the adaptation of a major agricultural weed during polyploidization.The genomic and transcriptomic resources of three Echinochloa species and new insights into the polyploidization-driven adaptive evolution would be useful for future breeding cereal crops. | Chu-Yu Ye Dongya Wu Lingfeng Mao Lei Jia Jie Qiu Sangting Lao Meihong Chen Bowen Jiang Wei Tang Qiong Peng Lang Pan Lifeng Wang Xiaoxiao Feng Longbiao Guo Chulong Zhang Elizabeth A.Kellogg Kenneth M.Olsen Lianyang Bai Longjiang Fan | 2020 | Molecular Plant2020，13，9： | 4 |
| 6 | Paving the Way to Open Data显示文摘It is easy to argue that open data are critical to enabling faster and more effective research discovery.In this article,we describe the approach we have taken at Wiley to support open data and to start enabling more data to be FAIR data(Findable,Accessible,Interoperable and Reusable)with the implementation of four data policies:“Encourages”,“Expects”,“Mandates”and“Mandates and Peer Reviews Data”.We describe the rationale for these policies and levels of adoption so far.In the coming months we plan to measure and monitor the implementation of these policies via the publication of data availability statements and data citations.With this information,we’ll be able to celebrate adoption of data-sharing practices by the research communities we work with and serve,and we hope to showcase researchers from those communities leading in open research. | Yan Wu Elizabeth Moylan Hope Inman Chris Graf | 2019 | Data Intelligence2019，1，4： | 3 |
| 7 | Patient Education Improves Patient Knowledge and Acceptance on Antiviral Therapy of Hepatitis C in Rural China显示文摘 | Ming Yang Hui-Ying Rao Bo Feng Elizabeth WU Lai Wei Anna S Lok | 2017 | Chinese Medical Journal2017，，22： | 2 |
| 8 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 9 | Reactive astrocytes promote the metastatic growth of breast cancer stem‐like cells by activating Notch signalling in brain显示文摘 | Fei Xing Aya Kobayashi Hiroshi Okuda Misako Watabe Sudha K. Pai Puspa R. Pandey Shigeru Hirota Andrew Wilber Yin‐Yuan Mo Brian E. Moore Wen Liu Koji Fukuda Megumi Iiizumi Sambad Sharma Yin Liu Kerui Wu Elizabeth Peralta Kounosuke Watabe | 2013 | EMBO Mol Med2013，，3： | 1 |
| 10 | Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels显示文摘 | Masato Kato Tina W. Han Shanhai Xie Kevin Shi Xinlin Du Leeju C. Wu Hamid Mirzaei Elizabeth J. Goldsmith Jamie Longgood Jimin Pei Nick V. Grishin Douglas E. Frantz Jay W. Schneider She Chen Lin Li Michael R. Sawaya David Eisenberg Robert Tycko Steven L. M | 2012 | Cell2012，，： | 1 |
| 11 | Disclosing Medical Errors to Patients: Attitudes and Practices of Physicians and Trainees显示文摘 | Lauris C. Kaldjian Elizabeth W. Jones Barry J. Wu Valerie L. Forman-Hoffman Benjamin H. Levi Gary E. Rosenthal | 2007 | Journal of General Internal Medicine2007，，7： | 1 |
| 12 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 13 | The formation and growth of intermetallics in composite solder显示文摘 | Yujing Wu Jennifer A. Sees Cyrus Pouraghabagher L. Ann Foster James L. Marshall Elizabeth G. Jacobs Russell F. Pinizzotto | 1993 | Journal of Electronic Materials1993，，7： | 1 |
| 14 | Early decision and college performance显示文摘 | Elizabeth J. Jensen Stephen Wu | 2010 | Economics of Education Review2010，，4： | 1 |
| 15 | Quality by design: Impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody显示文摘 | David Awotwe-Otoo Cyrus Agarabi Geoffrey K. Wu Elizabeth Casey Erik Read Scott Lute Kurt A. Brorson Mansoor A. Khan Rakhi B. Shah | 2012 | International Journal of Pharmaceutics (-)2012，，1： | 1 |
| 16 | Computer-supported team-based learning: The impact of motivation, enjoyment and team contributions on learning outcomes显示文摘 | Elizabeth Avery Gomez Dezhi Wu Katia Passerini | 2010 | Computers & Education2010，，： | 1 |
| 17 | Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes显示文摘 | Shu Wu Wena Chen Elizabeth Murphy | 1997 | J Biol Chem1997，272，12： | 1 |
| 18 | Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma显示文摘 | Xiang Chen Elizabeth Stewart Anang A. Shelat Chunxu Qu Armita Bahrami Mark Hatley Gang Wu Cori Bradley Justina McEvoy Alberto Pappo Sheri Spunt Marcus B. Valentine Virginia Valentine Fred Krafcik Walter H. Lang Monika Wierdl Lyudmila Tsurkan Viktor Tollem | 2013 | Cancer Cell2013，，6： | 1 |
| 19 | Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial显示文摘 | David Neal Franz Elena Belousova Steven Sparagana E Martina Bebin Michael Frost Rachel Kuperman Olaf Witt Michael H Kohrman J Robert Flamini Joyce Y Wu Paolo Curatolo Petrus J de Vries Vicky H Whittemore Elizabeth A Thiele James P Ford Gaurav Shah Helene | 2012 | The Lancet2012，，： | 1 |
| 20 | Multilevel Magnetic Resonance Imaging Analysis of Multifidus-Longissimus Cleavage Planes in the Lumbar Spine and Potential Clinical Applications to Wiltse?s Paraspinal Approach显示文摘 | Daniel Kyle Palmer Jonathan L. Allen Paul A. Williams Ashley Elizabeth Voss Vikram Jadhav David S. Wu Wayne K. Cheng | 2011 | Spine2011，，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员