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| 1 | Cellular and molecular aspects of gastric cancer显示文摘胃的癌症与变的负担仍然是一个全球杀手从发展了到发展中的世界。癌症沿着被定义由的一个多级式的过程发展不同组织学并且 pathophysiological 阶段。几基因、渐成说的改变调停从一个的转变上演到另外一个,这些在 oncogenes 包括变化,瘤压制或基因和房间骑车并且错配修理基因。在对胃的癌症的战斗的最重要的进展为这癌症作为最重要的获得的病因论的代理人与 Helicobacter pylori (H pylori ) 的角色的识别来了。最近的工作在阐明上集中了位于肿瘤的过程下面的复杂 host/microbial 相互作用。现在进这癌症的致病和阻止并且根除的前景有可观的卓见疾病成为了现实。也许更重要地, H 导致 pylori 的胃的致癌作用的学习为理解更复杂的人的癌症提供一个范例。在这评论,我们检验位于 H 下面的分子、细胞的事件导致 pylori 的胃的癌症。 | Malcolm G Smith Georgina L Hold Eiichi Tahara Emad M El-Omar | 2006 | World Journal of Gastroenterology2006，12，19： | 29 |
| 2 | Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years. | Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya | 2014 | World Journal of Gastroenterology2014，20，5： | 21 |
| 3 | Advances in the management of infertility in men with spinal cord injury显示文摘结合一根针的绳索受伤男搭挡要求帮助射精技术收集当时能进一步的精液在各种各样的帮助繁殖技术方法使用完成怀孕。不管原因或损害的水平支撑针的绳索损害的人的多数不能在性交期间射精。仅仅一个小少数能由手淫射精。阴茎振动刺激和 electroejaculation 是过去常检索精子的二个很普通的方法。象 prostatic 按摩和另外的药的附属物申请那样的另外的技术能被使用,但是结果是不一致的。如果所有另外的方法失败,外科的精子检索应该被看作最终手段。特殊注意必须由于在损害的水平下面源于刺激的自治 dysreflexia 的风险与 T6 和损害的喙的层次对病人被给予。如果,膀胱准备应该在刺激前被执行后退射精被期望。可勃起的机能障碍在针的绳索是无所不在的伤害了人口,但是容易通常被管理并且不在这些人提出一个障碍到精液检索。有针的绳索损害的人的精液分析参数不管检索的方法为这张人口是唯一的,通常作为正常精子集中,但是反常地介绍低精子活动性和生存能力。当精子检索在这张人口被需要时,强调应该被放在开始在诉诸更多的先进、侵略的外科的过程前试试阴茎振动刺激或 electroejaculation 的简单方法上。 | Emad Ibrahim Nancy L Brackett Charles M Lynne | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 4 | Systemic Naloxone Infusion May Trigger Spasticity in Patients With Spinal Cord Injury: Case Series显示文摘 | Nancy L Brackett Emad Ibrahim Andrei Krassioukov | 2007 | J Spinal Cord Med2007，30，： | 1 |
| 5 | Nonlinear total variation based noise removal algorithms显示文摘 | RUDIN L OSHER S EMAD F | 1992 | Physica D: Nonlinear Phenomena1992，60，14： | 1 |
| 6 | Mechanical and tribological properties of self-lubricating metal matrix nano- composites reinforced by carbon nanotubes (CNTs) and gra- phene-a review 显示文摘 | AFSANEH D M EMAD O PRADEEP L M | 2015 | Composites: Part B2015，77，： | 1 |
| 7 | A simple displacement- based model for predicting seimically induced overturning显示文摘 | Haider A A Nelson L Emad G | 2006 | Journal of Earthquake Engineering2006，10，6： | 1 |
| 8 | Nonlinear total variation based noise removal algorithms 显示文摘 | Rudin L Osher Stanley Fatemi Emad | 1992 | Physica D1992，60，14： | 1 |
| 9 | Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms显示文摘 | Emad M El-Omar Charles S Rabkin Marilie D Gammon Thomas L Vaughan Harvey A Risch Janet B Schoenberg Janet L Stanford Susan T Mayne James Goedert William J Blot Joseph F Fraumeni Wong-ho Chow | 2003 | Gastroenterology2003，，5： | 1 |
| 10 | Systemic Naloxone Infusi on May Trigger Spasticityin Patient s With Spinal Cord Injury: Case Series显示文摘 | Nancy L Emad l Andrei K | 2007 | J Spinal Cord Med2007，30，： | 1 |
| 11 | Congenital malaria显示文摘 | Emad S Saira L Seema H | 2008 | Pak J Med Sci2008，24，5： | 1 |
| 12 | Electro-tuning of surface state in two-dimensional-photonic crystals显示文摘 | Ali Soltani Vala Emad Rezaei Naser Hoseini l | 2011 | Phys Status Solidi A2011，208，18： | 1 |
| 13 | Surgical excision and immediate postoperative radiotherapy versus cryotherapy and intralesional steroids in the management of keloids: a prospective clinical trial 显示文摘 | Emad M Omidvari S Dastgheib L | 2010 | Med Princ Pract2010，19，5： | 1 |
| 14 | Advances in endoscopic retrograde cholangiopancreatography cannulation显示文摘Endoscopic retrograde cholangiopancreatography is an important tool in the diagnosis and treatment of pancreatobiliary diseases.A critical step in this procedure is deep cannulation of the bile duct as failure of cannulation generally results in an aborted procedure and failed intervention.Expert endoscopists usually achieve a high rate of successful cannulation while those less experienced typically have a much lower rate and a greater incidence of complications.Prolonged attempts at cannulation can result in significant morbidity to patients,anxiety for endoscopists,unnecessary radiation exposure and inefficient patient care.Here we review the most common endoscopic techniques used to achieve selective biliary cannulation.Pharmacologic aids to cannulation are also discussed briefly in this review. | Emad Qayed Ashley L Reid Field F Willingham Steve Keilin | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，4： | 1 |
| 15 | Forensic and homeland security applica- tions of modern portable Raman spectroscopy 显示文摘 | Emad L Izake | 2010 | Fo- rensic Sci Int2010，202，： | 1 |
| 16 | Surgical excision and immediate post-operative radiotherapy versus cryotherapy and in- tralesional steroids in the management of keloids:a prospective clinical trial显示文摘 | Emad M Omidvari S Dastgheib L | 2010 | Med Princ Pract2010，19，5： | 1 |
| 17 | Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters显示文摘Escherichia coli uracil:proton symporter UraA 是 nucleobase/ascorbate transporter (NAT ) 或 nucleobase/cation symporter 的一个原型的成员 2 (NCS2 ) 家庭,它对应于人的溶质搬运人家庭 SLC23。UraA 由被组织成二个不同领域,核心领域和门领域的 14 个 transmembrane 片断(TM ) 组成,也是的结构的褶层由 SLC4 和 SLC26 transporters 分享了。这里我们在场 UraA 的水晶结构在 2.5 点处于一个堵塞状态跳了到 uracil?分辨率。有以前报导的里面打开 UraA 的结构的比较象门领域的 intra 域重新整理一样揭示在核心领域和门领域之间的显著相对运动。堵塞 UraA 形式一在门领域被二个核心领域夹的结构更暗淡。在 vitro 并且在生物化学的描述显示出的 vivo,那 UraA 在平衡在之间更暗淡并且在所有测试净化的微粒的单体,当更暗淡的形成为运输活动是必要的时。在二聚的 UraA 和最近报导的里面面对的二聚的 UapA 之间的结构的比较提供重要卓见进 SLC23 transporters 的运输机制。 | Xinzhe Yu Guanghui Yang Chuangye Yan Javier L Baylon Jing Jiang He Fan Guifeng Lu Kazuya Hasegawa Hideo Okumura Tingliang Wang Emad Tajkhorshid Shuo Li Nieng Yan | 2017 | Cell Research2017，27，8： | 1 |
| 18 | Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms显示文摘 | Emad M El-Omar Charles S Rabkin Marilie D Gammon Thomas L Vaughan Harvey A Risch Janet B Schoenberg Janet L Stanford Susan T Mayne James Goedert William J Blot Joseph F Fraumeni Wong-ho Chow | 2003 | Gastroenterology2003，，5： | 1 |
| 19 | Stochastic Framework for Solving the Prey-Predator Delay Differential Model of Holling Type-Ⅲ显示文摘The current research aims to implement the numerical resultsfor the Holling third kind of functional response delay differential modelutilizing a stochastic framework based on Levenberg-Marquardt backpropagationneural networks (LVMBPNNs). The nonlinear model depends uponthree dynamics, prey, predator, and the impact of the recent past. Threedifferent cases based on the delay differential system with the Holling 3^(rd) type of the functional response have been used to solve through the proposedLVMBPNNs solver. The statistic computing framework is provided byselecting 12%, 11%, and 77% for training, testing, and verification. Thirteennumbers of neurons have been used based on the input, hidden, and outputlayers structure for solving the delay differential model with the Holling 3rdtype of functional response. The correctness of the proposed stochastic schemeis observed by using the comparison performances of the proposed and referencedata-based Adam numerical results. The authentication and precision ofthe proposed solver are approved by analyzing the state transitions, regressionperformances, correlation actions, mean square error, and error histograms. | Naret Ruttanaprommarin Zulqurnain Sabir Rafaél Artidoro Sandoval Nez Emad Az-Zo’bi Wajaree Weera Thongchai Botmart Chantapish Zamart | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 20 | Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish Multicenter Registry显示文摘BACKGROUND The association between digoxin and mortality is an unclear issue.In older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is scarce.Our aim is to assess the safety of digoxin in nonagenarian patients with AF.METHODS We evaluated data from 795 nonagenarian patients with non-valvular AF from the Spanish Multicenter Registry.We analyzed the relationship between digoxin and all-cause mortality with the Cox proportional-hazards model.RESULTS Follow-up was 27.7±18.3 months.Mean age was 92.5±3.8 years,and 71%of nonagenarian patients were female.Digoxin was not associated with increased risk of mortality[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortality in the subgroup with estimated glomerular filtration rate(eGFR)<30 mL/min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 mL/min per 1.73 m^(2) and≥60 mL/min per 1.73 m^(2)).When exploring the risk of mortality according to sex,male subgroup was associated with an in-crease in mortality(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in females subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart failure,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 vs.aHR=1.15,95%CI:0.90−1.47,P=0.273,respectively).CONCLUSIONS In our large registry of nonagenarian patients with AF,we did not find an association between digoxin and mortality in the total sample.However,in the subgroup analyses,we found an increase in mortality with the use of digoxin in men and in patients with an eGFR<30 mL/min per 1.73 m^(2). | Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubelos-Fernández Álvaro López-Masjuán Ríos María Melendo-Viu AndrésÍñiguez-Romo | 2021 | Journal of Geriatric Cardiology2021，18，10： | 0 |
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