5篇
您的检索式：作者名="Emily Lynch"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 2 | The insect-killing bacterium Photorhabdus luminescens has the lowest mutation rate among bacteria显示文摘Mutation is a primary source of genetic variation that is used to power evolution.Many studies,however,have shown that most mutations are deleterious and,as a result,extremely low mutation rates might be benefcial for survival.Using a mutation accumulation experiment,an unbiased method for mutation study,we found an extremely low base-substitution mutation rate of 5.94×10^(-11) per nucleotide site per cell division(95%Poisson confdence intervals:4.65×10^(-11),7.48×10^(-11))and indel mutation rate of 8.25×10^(-12) per site per cell division(95%confdence intervals:3.96×10^(-12),1.52×10^(-11))in the bacterium Photorhabdus luminescens ATCC29999.The mutations are strongly A/T-biased with a mutation bias of 10.28 in the A/T direction.It has been hypothesized that the ability for selection to lower mutation rates is inversely proportional to the efective population size(drift-barrier hypothesis)and we found that the efective population size of this bacterium is signifcantly greater than most other bacteria.This fnding further decreases the lower-bounds of bacterial mutation rates and provides evidence that extreme levels of replication fdelity can evolve within organisms that maintain large efective population sizes. | Jiao Pan Emily Williams Way Sung Michael Lynch Hongan Long | 2021 | Marine Life Science & Technology2021，3，1： | 2 |
| 3 | Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)显示文摘 | Dominique S. Michaud Alina Vrieling Li Jiao Julie B. Mendelsohn Emily Steplowski Shannon M. Lynch Jean Wactawski-Wende Alan A. Arslan H. Bas Bueno-de-Mesquita Charles S. Fuchs Myron Gross Kathy Helzlsouer Eric J. Jacobs Andrea LaCroix Gloria Petersen Wei | 2010 | Cancer Causes & Control2010，，8： | 1 |
| 4 | The Arabidopsis thaliana ABSCISIC ACID - INSENSITIVE8 Locus Encodes a Novel Protein Mediating Abscisic Acid and Sugar Responses Essential for Growth显示文摘 | Ines Brocard - Gifford Tim J Lynch M Emily Garcia | 2004 | The Plant Cell2004，16，： | 1 |
| 5 | A small plant-specific protein family of ABI five binding proteins (AFPs) regulates stress response in germinating Arabidopsis seeds and seedlings显示文摘 | Mary Emily Garcia Tim Lynch Julian Peeters Chris Snowden Ruth Finkelstein | 2008 | Plant Molecular Biology2008，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员