|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model显示文摘Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors(SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. With 10% of Americans prescribed antidepressants, the potential of SSRIs to impair bone healing may adversely affect millions of patients' ability to heal after sustaining trauma. Here, we investigate the effect of the SSRI sertraline on bone healing through pre-treatment with(10 mg·kg^(-1) sertraline in drinking water, n = 26) or without(control, n = 30) SSRI followed by the creation of a 5-mm calvarial defect. Animals were randomized into three surgical groups:(a) empty/sham,(b) implanted with a DermaMatrix scaffold soak-loaded with sterile PBS or(c) DermaMatrix soak-loaded with542.5 ng BMP2. SSRI exposure continued until sacrifice in the exposed groups at 4 weeks after surgery. Sertraline exposure resulted in decreased bone healing with significant decreases in trabecular thickness, trabecular number and osteoclast dysfunction while significantly increasing mature collagen fiber formation. These findings indicate that sertraline exposure can impair bone wound healing through disruption of bone repair and regeneration while promoting or defaulting to scar formation within the defect site. | R.Nicole Howie Samuel Herberg Emily Durham Zachary Grey Grace Bennfors Mohammed Elsalanty Amanda C.LaRue William D.Hill James J.Cray | 2018 | International Journal of Oral Science2018，10，4： | 5 |
| 2 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 3 | “Sideways”: Results of Repair of Biliary Injuries Using a Policy of Side-To-Side Hepatico-Jejunostomy显示文摘 | Emily R. Winslow Elizabeth A. Fialkowski David C. Linehan William G. Hawkins Daniel D. Picus Steven M. Strasberg | 2009 | Annals of Surgery2009，，3： | 3 |
| 4 | Efficient Gene Targeting in Maize Using Inducible CRISPR-Cas9 and Marker-free Donor Template显示文摘CRISPR-Cas9 is a powerful tool for generating targeted mutations and genomic deletions.However,precise gene insertion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is fully realized in plant breeding.Here,we report high-frequency,selectable marker-free intra-genomic gene targeting(GT)in maize.Heat shock-inducible Cas9 was used for generating targeted double-strand breaks and simultaneous mobilization of the donor template from pre-integratad T-DNA.The construct was designed such that release of the donor template and subsequent DNA repair activated expression of the selectable marker gene within the donor locus.This approach generated up to 4.7%targeted insertion of the donor sequence into the target locus in TO plants,with up to 86%detected donor template release and 99%mutation rate being observed at the donor loci and the genomic target site,respectively.Unlike previous in planta or intra-genomic homologous recombination reports in which the original chimeric GT plants required extensive progeny screening in the next generation to identify non-chimeric GT individuals,our method provides non-chimeric heritable GT in one generation. | Pierluigi Barone Emily Wu Brian Lenderts Ajith Anand William Gordon-Kamm Sergei Svitashev Sandeep Kumar | 2020 | Molecular Plant2020，13，8： | 3 |
| 5 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 6 | The insect-killing bacterium Photorhabdus luminescens has the lowest mutation rate among bacteria显示文摘Mutation is a primary source of genetic variation that is used to power evolution.Many studies,however,have shown that most mutations are deleterious and,as a result,extremely low mutation rates might be benefcial for survival.Using a mutation accumulation experiment,an unbiased method for mutation study,we found an extremely low base-substitution mutation rate of 5.94×10^(-11) per nucleotide site per cell division(95%Poisson confdence intervals:4.65×10^(-11),7.48×10^(-11))and indel mutation rate of 8.25×10^(-12) per site per cell division(95%confdence intervals:3.96×10^(-12),1.52×10^(-11))in the bacterium Photorhabdus luminescens ATCC29999.The mutations are strongly A/T-biased with a mutation bias of 10.28 in the A/T direction.It has been hypothesized that the ability for selection to lower mutation rates is inversely proportional to the efective population size(drift-barrier hypothesis)and we found that the efective population size of this bacterium is signifcantly greater than most other bacteria.This fnding further decreases the lower-bounds of bacterial mutation rates and provides evidence that extreme levels of replication fdelity can evolve within organisms that maintain large efective population sizes. | Jiao Pan Emily Williams Way Sung Michael Lynch Hongan Long | 2021 | Marine Life Science & Technology2021，3，1： | 2 |
| 7 | Importance of Low Preoperative Platelet Count in Selecting Patients for Resection of Hepatocellular Carcinoma: A Multi-Institutional Analysis显示文摘 | Shishir K. Maithel Peter J. Kneuertz David A. Kooby Charles R. Scoggins Sharon M. Weber Robert C.G. Martin Kelly M. McMasters Clifford S. Cho Emily R. Winslow William C. Wood Charles A. Staley | 2011 | Journal of the American College of Surgeons2011，，4： | 2 |
| 8 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 9 | Pancreatic Fistula Following Pancreaticoduodenectomy: Clinical Predictors and Patient Outcomes显示文摘 | C. Max Schmidt Jennifer Choi Emilie S. Powell Constantin T. Yiannoutsos Nicholas J. Zyromski Attila Nakeeb Henry A. Pitt Eric A. Wiebke James A. Madura Keith D. Lillemoe William Jarnagin | 2009 | HPB Surgery2009，，： | 2 |
| 10 | Prospective Breast Cancer Risk Predicition Model for Women Undergoing Screening Mammography显示文摘 | William EB Emily W Rachel BB | 2006 | J Natl Cancer Inst2006，98，17： | 1 |
| 11 | Pediatric Evaluation of the Bispectral Index (BIS) Monitor and Correlation of BIS with End-tidal Sevoflurane Concentration in Infants and Children 显示文摘 | William TD Emily LS David R | 2000 | Anesth Analg2000，90，4： | 1 |
| 12 | Long noncoding RNAs are rarely translated in two human cell lines显示文摘 | Balázs Bánfai Hui Jia Jainab Khatun Emily Wood Brian Risk William E. Gundling Anshul Kundaje Harsha P. Gunawardena Yanbao Yu Ling Xie Krzysztof Krajewski Brian D. Strahl Xian Chen Peter Bickel Morgan C. Giddings James B. Brown Leonard Lipovich | 2012 | Genome Research2012，，9： | 1 |
| 13 | Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Blood Pressure: A Systematic Review and Meta-Analysis显示文摘 | William L. Baker Lindsay R. Smyth Daniel M. Riche Emily M. Bourret Kevin W. Chamberlin William B. White | 2014 | Journal of the American Society of Hypertension2014，，： | 1 |
| 14 | Molecular and cellular analysis of embryonic avian tongue development显示文摘 | Ruijin Huang Emily R. Lang William R. Otto Bodo Christ K. Patel | 2001 | Anatomy and Embryology2001，，3： | 1 |
| 15 | Prospective breast cancer risk prediction model for women undergoing screening mammogra-phy显示文摘 | William EB Emily W Rachel BB | 2006 | J Natl Cancer Inst2006，98，17： | 1 |
| 16 | Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons显示文摘 | Anne P. Beigneux Brandon S.J. Davies Peter Gin Michael M. Weinstein Emily Farber Xin Qiao Franklin Peale Stuart Bunting Rosemary L. Walzem Jinny S. Wong William S. Blaner Zhi-Ming Ding Kristan Melford Nuttaporn Wongsiriroj Xiao Shu Fred de Sauvage Robert | 2007 | Cell Metabolism2007，，4： | 1 |
| 17 | Cost-effectiveness of Crohn's disease post-operative care显示文摘AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn's disease following intestinal resection.METHODS: In the 'POCER' study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care(6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin(FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 mo.RESULTS: Sixty patients(active care n = 43, standardcare n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those inremission [ $ 26347( IQR 25045-27485) vs $2729(IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence prevented. CONCLUSION: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated. | Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 18 | Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome显示文摘 | Rajvir Singh Emily Smith Mohsen Fathzadeh Wenzhong Liu Gwang‐Woong Go Lakshman Subrahmanyan Saeed Faramarzi William McKenna Arya Mani | 2013 | Human Mutation2013，，9： | 1 |
| 19 | Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome显示文摘 | Rajvir Singh Emily Smith Mohsen Fathzadeh Wenzhong Liu Gwang‐Woong Go Lakshman Subrahmanyan Saeed Faramarzi William McKenna Arya Mani | 2013 | Human Mutation2013，，： | 1 |
| 20 | Implanted adipose progenitor cells as physicochemical regulators of breast cancer显示文摘 | Emily M. Chandler Bo Ri Seo Joseph P. Califano Roberto C. Andresen Eguiluz Jason S. Lee Christine J. Yoon David T. Tims James X. Wang Le Cheng Sunish Mohanan Mark R. Buckley Itai Cohen Alexander Yu Nikitin Rebecca M. Williams Delphine Gourdon Cynthia A. R | 2012 | Proceedings of the National Academy of Sciences2012，，25： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员