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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Combustion synthesis of metallic foams from nanocomposite reactants 显示文摘 | Emily M H Michelle L P Jouet R J | 2006 | Intermetallics2006，14，6： | 1 |
| 3 | Sequential interval motif search:unrestricted database surveys of global MS/MS data sets for detection of putative post-translational modifications显示文摘 | Liu J Erassov A Halina P Canete M Nguyen D V Chung C Cagney G Ignatchenko A Fong V Emili A | | 0，，20： | 1 |
| 4 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 5 | Predator vocalizations affcet foraging trade-offs of Northern cardinals显示文摘 | Stanback M T Emily M P | 2010 | The Wilson journal of Ornithology2010，122，1： | 1 |
| 6 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 7 | Influence of an Insertion Variant in the 5'UTR of the Endothelin- 1 Gene on Orthostatie Intolerance 显示文摘 | Robert Winker M D Emily M Garland P H D | 2005 | The American Journal of The Medical Science2005，330，： | 1 |
| 8 | Validity of Physical activity Intensity Predic- tions by Actigraph, Actical, and RT3 Accelerometers显示文摘 | MEGAN P ROTHNEY EMILY V SCHAEFER MEGAN M LEENA | 2008 | Obesity (Silver Spring)2008，16，8： | 1 |
| 9 | Splenic Injury Due to Colonoscopy: Analysis of the World Literature, a New Case Report, and Recommendations for Management显示文摘 | Michetti Christopher P Smeltzer Emily Fakhry Samir M | 2010 | The American Surgeon2010，，11： | 1 |
| 10 | Differences in skeletal microarchitecture and strength in African‐American and white women显示文摘 | Melissa S Putman Elaine W Yu Hang Lee Robert M Neer Elizabeth Schindler Alexander P Taylor Emily Cheston Mary L Bouxsein Joel S Finkelstein | 2013 | J Bone Miner Res2013，，10： | 1 |
| 11 | Bisphenol A is Re- leased from Polycarbonate Drinking Bottles and Mimics the Neurotoxic Actions of Estrogen in Developing Cerebellar Neu- rons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 12 | Validity of physical activity intensity prediction by acti graph, actical, and RT3 acceleromete显示文摘 | MEGAN P ROTHNEY EMILY V SCHAEFER MEGAN M NEUMANN | 2008 | Obesity2008，，： | 1 |
| 13 | Meta-analysis of the effects of educational and psychosocial interventions on management of diabetes mellitus显示文摘 | Deborah P Emily M Margaret H | 1998 | J Clin Epidemi- ol1998，41，10： | 1 |
| 14 | Nutrient retention and the problem of hydrologic disconnection in streams and wetlands 显示文摘 | Stephen M P Robert A J Emily H S | 2012 | Ecosystems2012，15，3： | 1 |
| 15 | Molecular and isotopic compositions of lipids in bivalve shells: a new prospect for molecular paleontology显示文摘 | Emily A Cobabe M P | 1995 | Geochimica et Cosmoehimica Acta1995，59，： | 1 |
| 16 | Influence of seasonality and vegetation type on suburban microclimates 显示文摘 | EMILY B P JOSEPH P M | 2010 | Urban Ecosyst2010，13，4： | 1 |
| 17 | Hepatitis C Infection Among Pregnant Women in British Columbia: Reported Prevalence and Critical Appraisal of Current Prenatal Screening Methods显示文摘 | Blasig Audrey Wagner Emily C Pi David Bigham Mark Remple Valencia P Craib Kevin J P Doyle Patrick Dobson Simon Yoshida Eric M Patrick David Krajden Mel Money Deborah M | 2011 | Canadian Journal of Public Health2011，，2： | 1 |
| 18 | The ionothermal synthesis of SIZ-6-a layerd aluminophosphate 显示文摘 | Emily R P Paul S W Russell E M | 2006 | Chem Common2006，，： | 1 |
| 19 | Infulence of seasonality and vegetation type on suburban microclimates显示文摘 | Emily B P Joseph P M | 2010 | Urban Ecosyst2010，13，4： | 1 |
| 20 | Bis- phenol A is Released from Polycarbonate Drinking Bottles and Mimics the Neurotoxic Actions of Estro- gen in Developing Cerebellar Neurons 显示文摘 | HOA H L EMILY M C JASON P C etal | 2008 | Toxicol Lett2008，176，： | 1 |
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