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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Phoenixin: uncovering its receptor, signaling and functions显示文摘Phoenixin (PNX ) 是被连接了到繁殖功能的最新发现的肽,两个在视下丘和垂体。这评论将集中于与这新奇 neuropeptide 有关的最近的发现。开始, PNX 增加了释放刺激的荷尔蒙(GnRH ) 的 gonadotropin,这被发现从垂体房间的 luteinizing 荷尔蒙(LH ) 版本。重要地,在扩大的雌老鼠的 PNX 击倒到 2.3 天的动情期的周期。用新奇 hypothalamic 房间线,我们发现 PNX 在 kisspeptin (吻) 和 GnRH 基因表示和分泌物上有一个 stimulatory 角色。PNX 受体用 GPR173 击倒的 siRNA 被揭开,孤儿受体要求了绑 PNX。我们发现了在 hypothalamic 神经原通过蛋白质 kinase A (PKA ) 发信号的 PNX-R。很多研究表明的 Althuogh 那 PNX 在繁殖功能起一个重要作用,也有证据,它可以有另外的功能,调整心,喂,记忆,和焦虑,两个在大脑和圆周。 | Emma K MCILWRAITH Denise D BELSHAM | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Advanced multimodality imaging of inflammatory bowel disease in 2015: An update显示文摘The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques. | Emma Stanley Heather K Moriarty Carmel G Cronin | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 5 | Cellular and molecular physiology of volume-sensitive anion channels显示文摘 | Strange K Emma F Jackson P S | 1996 | Am J Physiol1996，270，： | 1 |
| 6 | Ultrasonically assisted synthesis and degradation of poly ( dimethyl siloxane) 显示文摘 | Gareth J P Matthew P H Emma N K W | 1996 | Polymer1996，37，12： | 1 |
| 7 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 8 | Spatial analysis of human granulocytic ehrlichiosis near lyme,Connecticut显示文摘 | Emma K Chaput JIM Robert H | 2002 | Emerging Inf Dis2002，8，： | 1 |
| 9 | Procuring Service Innovations: Contractor Selection for Partnering Projects 显示文摘 | Anna K Emma B | 2007 | Project Management2007，，25： | 1 |
| 10 | Intracellular electrolytes regulate the volume set point of the organic osmolytel anion channel(VSOACs)显示文摘 | Emma F Mcmanns M Strange K | 1997 | Am J Physiol1997，272，： | 1 |
| 11 | Comparison of extraction methods for sampling of low molecular compounds in poly- mers degraded during recycling显示文摘 | Johanna M Emma S Sigbritt K | 2008 | European Polymer Journal2008，44，6： | 1 |
| 12 | Chemical and Physical characterization of emissions from birch wood combustion in a wood stove显示文摘 | Adam K Michael O | 2002 | Atmospheric Environment2002，36，5： | 1 |
| 13 | Aviation fuel and future oil production scenarios显示文摘 | EMMA NYGREN K JELL ALEKLETT MIKAEL HOOK | 2009 | En- ergy Policy2009，37，10： | 1 |
| 14 | Transverse-to- longitudinal emittance exchange to improve performance of high-gain free-electron lasers显示文摘 | Emma P Huang Z Kim K J | 2006 | Physical Review St Accelerators and Beams2006，9，10： | 1 |
| 15 | Spatial analysis of human granulocytic ehrlichiosis near Lyme, connectiuct显示文摘 | Emma K C James I M Robert H | 2002 | Emerg Infect Dis2002，8，9： | 1 |
| 16 | Enrichment of extruded snack products with coproducts from chestnut mushroom(Agrocybe aegerita)production:interactions between dietary fiber,physicochemical characteristics,and glycemic load显示文摘 | Brennan Margaret A Derbyshire Emma Tiwari Brijesh K | 2012 | Journal of Agricultural and Food Chemistry2012，60，43： | 1 |
| 17 | Redox Control in Heme Proteins:Electrostatic Substitution in the Active Site of Leghemoglobin显示文摘 | Deborah K Jones Neesha Patel Emma Lloyd Raven | 2002 | Archives of Biochemistry and Biophysics2002，400，： | 1 |
| 18 | Presence of terminal N-acetylgalactosamine,8-1, 4-N-acetylglucosamine residues on O-linked oligosaccharides from gastric MUC5AC: involvement in Helicobacter pylori colonization显示文摘 | DIARMUID T K EMMA C S SARA K L | 2012 | Glycobiology2012，22，8： | 1 |
| 19 | Dental age in Central Poland 显示文摘 | Ingrid R-K Emma K-R Pawel K | 2008 | Forensic Science International2008，，1： | 1 |
| 20 | Promoting microbial immobilization of soil nitrogen during restoration of abandoned agricultural fields by organic additions显示文摘 | Tibor Szili-Kovács Katalin T?r?k Emma L. Tilston David W. Hopkins | 2007 | Biology and Fertility of Soils2007，，6： | 1 |
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