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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 3 | Continuous quality improvement methodology: a case study on multidisciplinary collaboration to improve chlamydia screening显示文摘This article illustrates quality improvement(QI)methodology using an example intended to improve chlamydia screening in women.QI projects in healthcare provide great opportunities to improve patient quality and safety in a real-world healthcare setting,yet many academic centres lack training programmes on how to conduct QI projects.The choice of chlamydia screening was based on the significant health burden chlamydia poses despite simple ways to screen and treat.At the University of Michigan,we implemented a multidepartment process to improve the chlamydia screening rates using the plan-do-check-act model.Steps to guide QI projects include the following:(1)assemble a motivated team of stakeholders and leaders;(2)identify the problem that is considered a high priority;(3)prepare for the project including support and resources;(4)set a goal and ways to evaluate outcomes;(5)identify the root cause(s)of the problem and prioritise based on impact and effort to address;(6)develop a countermeasure that addresses the selected root cause effectively;(7)pilot a small-scale project to assess for possible modifications;(8)large-scale roll-out including education on how to implement the project;and(9)assess and modify the process with a feedback mechanism.Using this nine-step process,chlamydia screening rates increased from 29%to 60%.QI projects differ from most clinical research projects by allowing clinicians to directly improve patients’health while contributing to the medical science body.This may interest clinicians wishing to conduct relevant research that can be disseminated through academic channels. | Allison Ursu Grant Greenberg Michael McKee | 2019 | Family Medicine and Community Health2019，7，2： | 7 |
| 4 | Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema显示文摘 | Michael J. Elman Lloyd Paul Aiello Roy W. Beck Neil M. Bressler Susan B. Bressler Allison R. Edwards Frederick L. Ferris Scott M. Friedman Adam R. Glassman Kellee M. Miller Ingrid U. Scott Cynthia R. Stockdale Jennifer K. Sun | 2010 | Ophthalmology2010，，6： | 5 |
| 5 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 6 | Immune Modulation in Cancer with Antibodies显示文摘 | David B. Page Michael A. Postow Margaret K. Callahan James P. Allison Jedd D. Wolchok | 2014 | Annual Review of Medicine2014，，： | 2 |
| 7 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 8 | Atherosclerosis and interferon-γ: New insights and therapeutic targets显示文摘 | Voloshyna Iryna Michael J. Littlefield Allison B. Reiss | 2013 | Trends in Cardiovascular Medicine2013，，： | 2 |
| 9 | Electrical Stimulation Therapy for Dysphagia: Descriptive Results of Two Surveys显示文摘 | Michael A. Crary PhD Giselle D. Carnaby-Mann MPH PhD Allison Faunce BA | 2007 | Dysphagia2007，，3： | 1 |
| 10 | Predominance of Ehrlichia ewingii in Missouri Dogs显示文摘 | Allison M Steben LS Michael AS | 2003 | J Clin Microbiol2003，41，： | 1 |
| 11 | Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update显示文摘 | Antonio C. Wolff M. Elizabeth H. Hammond David G. Hicks Mitch Dowsett Lisa M. McShane Kimberly H. Allison Donald C. Allred John M.S. Bartlett Michael Bilous Patrick Fitzgibbons Wedad Hanna Robert B. Jenkins Pamela B. Mangu Soonmyung Paik Edith A. Perez Mi | 2013 | Journal of Clinical Oncology2013，，： | 1 |
| 12 | Metformin Improves Vascular Function in Insulin-Resistant Rats显示文摘 | Prasad V. G. Katakam Michael R. Ujhelyi Margarethe Hoenig Allison W. Miller | 2000 | Hypertension: Journal of the American Heart Association ( Part )2000，，1： | 1 |
| 13 | 持续质量改进方法学:一项关于改善衣原体筛查的多学科合作的案例研究显示文摘本文旨在通过一个改善女性衣原体筛查的示例来解读质量改进方法学。医疗保健中的质量改进项目为在现实世界的医疗环境中提高患者照护质量和安全性提供了很好的机遇,但很多学术中心缺乏如何开展质量改进项目的培训计划。选择进行衣原体筛查,是因为尽管有简单的筛查和治疗方法,衣原体仍造成了沉重的健康负担。密歇根大学实施了一个多部门流程,使用计划-执行-检查-处理模型来提高衣原体筛查率。指导质量改进项目的步骤包括以下部分:(1)组建一个具有主动性的利益相关者和领导者团队;(2)确定被认为具有较高优先级的问题;(3)为项目做好支持和资源方面的准备;(4)设定评估结果的目标和方法;(5)根据问题的影响和解决问题的努力,确定产生问题的根本原因和确定优先事项;(6)制定有效解决所选定的根本原因的对策;(7)在小型项目进行试点,以评估可能的修订;(8)大规模推广,包括如何实施项目的教育工作;(9)利用反馈机制评估和修改过程。使用这个九步法,衣原体筛查率从29%增加到了60%。质量改进项目与大多数临床研究项目不同,其允许临床医生在为医学科学本身做出贡献的同时,也直接改善患者的健康状况。这可能会吸引希望进行这种可以通过学术渠道传播的研究的临床医生的兴趣。 | Allison Ursu Grant Greenberg Michael McKee(著) 汪洋(译) 韩建军 许岩丽 杨辉(审校) | 2019 | 中国全科医学2019，22，25： | 1 |
| 14 | Breath Biopsy^(®) to Identify Exhaled Volatile Organic Compounds Biomarkers for Liver Cirrhosis Detection显示文摘Background and Aims:The prevalence of chronic liver dis-ease in adults exceeds 30%in some countries and there is significant interest in developing tests and treatments to help control disease progression and reduce healthcare burden.Breath is a rich sampling matrix that offers non-invasive so-lutions suitable for early-stage detection and disease moni-toring.Having previously investigated targeted analysis of a single biomarker,here we investigated a multiparametric approach to breath testing that would provide more robust and reliable results for clinical use.Methods:To identify can-didate biomarkers we compared 46 breath samples from cir-rhosis patients and 42 from controls.Collection and analysis used Breath Biopsy OMNI™,maximizing signal and contrast to background to provide high confidence biomarker detec-tion based upon gas chromatography mass spectrometry(GC-MS).Blank samples were also analyzed to provide de-tailed information on background volatile organic compounds(VOCs)levels.Results:A set of 29 breath VOCs differed significantly between cirrhosis and controls.A classification model based on these VOCs had an area under the curve(AUC)of 0.95±0.04 in cross-validated test sets.The seven best performing VOCs were sufficient to maximize classifica-tion performance.A subset of 11 VOCs was correlated with blood metrics of liver function(bilirubin,albumin,prothrom-bin time)and separated patients by cirrhosis severity using principal component analysis.Conclusions:A set of seven VOCs consisting of previously reported and novel candidates show promise as a panel for liver disease detection and mon-itoring,showing correlation to disease severity and serum biomarkers at late stage. | Giuseppe Ferrandino Giovanna De Palo Antonio Murgia Owen Birch Ahmed Tawfike Rob Smith Irene Debiram-Beecham Olga Gandelman Graham Kibble Anne Marie Lydon Alice Groves Agnieszka Smolinska Max Allsworth Billy Boyle Marc P.van der Schee Michael Allison Rebecca C.Fitzgerald Matthew Hoare Victoria K.Snowdon | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 15 | C3d of complement as a molecular adjuvant:bridging innate acquired immunity显示文摘 | Paul W D Michael D A Allison S A | 1996 | Science1996，271，5247： | 1 |
| 16 | Association Between Annual Visit-to-Visit Blood Pressure Variability and Stroke in Postmenopausal Women: Data From the Women?s Health Initiative显示文摘 | Daichi Shimbo Jonathan D. Newman Aaron K. Aragaki Michael J. LaMonte Anthony A. Bavry Matthew Allison JoAnn E. Manson Sylvia Wassertheil-Smoller | 2012 | Hypertension2012，，3： | 1 |
| 17 | Utilization of Interventional Radiology in the Postoperative Management of Patients after Surgery for Locally Advanced and Recurrent Rectal Cancer显示文摘 | Llaguna Omar H Calvo Benjamin F Stitzenberg Karyn B Deal Allison M Burke Charles T Dixon Robert G Stavas Joseph M Meyers Michael O | 2011 | The American Surgeon2011，，8： | 1 |
| 18 | Novel Risk Factors for Peripheral Arterial Disease in the Multiethnic Study of Atherosclerosis is (MESA) 显示文摘 | Matthew A Allison Michael Criqui Univ of California | 2005 | Circulation2005，111，14： | 1 |
| 19 | Ethnicity and Peripheral Arterial Disease: The San Diego Population Study显示文摘 | Michael H. Criqui Veronica Vargas Julie O. Denenberg Elena Ho Matthew Allison Robert D. Langer Anthony Gamst Warner P. Bundens Arnost Fronek | 2005 | Circulation2005，，17： | 1 |
| 20 | A novel de novo mutation of SCN8A (Na v 1.6) with enhanced channel activation in a child with epileptic encephalopathy显示文摘 | Mark Estacion Janelle E. O’Brien Allison Conravey Michael F. Hammer Stephen G. Waxman Sulayman D. Dib-Hajj Miriam H. Meisler | 2014 | Neurobiology of Disease2014，，： | 1 |
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