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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs显示文摘 | Solberg R Enot D Deigner HP | 2010 | PLoS One2010，5，3： | 1 |
| 3 | Hierarchicalmetabolomics demonstrates substantial compositional similaritybetween genetically modified and conventional potato crops 显示文摘 | Catchpole G S Beckmann M Enot D P | 2005 | Proceedings of the National Academy of Sciences of the UnitedStates of America2005，102，14： | 1 |
| 4 | Rice blast infection ofBrachypodium distachyon as a model system to study dynamic host/pathogen interactions显示文摘 | Parker D Beckmann M Enot D P | 2008 | Nature Protocols2008，3，3： | 1 |
| 5 | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs显示文摘 | Solberg R Enot D Deigner H P | 2010 | PLoS One2010，5，3： | 1 |
| 6 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops 显示文摘 | Catchpole G S Beckmann M Enot D P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 7 | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs 显示文摘 | Solberg R Enot D Deigner HP | 2010 | PLoS One2010，5，3： | 1 |
| 8 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops 显示文摘 | CATCHPOLE G S BECKMANN M ENOT D P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 9 | Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen in- teractions 显示文摘 | Parker D Beckmann M Enot D P | 2008 | Nature Protocols2008，3，： | 1 |
| 10 | Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivars显示文摘 | BECKMANN M ENOT D P OVERY D P | 2007 | J Agric Food Chem2007，55，9： | 1 |
| 11 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops显示文摘 | Catchpole G S Beckmamm M Enot D P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 12 | Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in popato cultivars 显示文摘 | Manfered B Enot D P Overy D P | 2007 | J Agrie Food Chem2007，55，9： | 1 |
| 13 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops显示文摘 | Catchpole G S Beckmann M Enot D P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 14 | Representation, compari- son, and interpretation of metabolome fingerprint data for total compo- sition analysis and quality trait investigation in potato cultivars 显示文摘 | Beckmann M Enot D P Overy D P | 2007 | Journal of Agricultural and Food Chemistry2007，55，9： | 1 |
| 15 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops 显示文摘 | CATCHPOLE G S BECKMANN M ENOT D P et a1 | 2005 | Proc Nat! Acad Sci2005，102，14： | 1 |
| 16 | Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops显示文摘 | CATCHPOLE G S BECKMANN M ENOT D P | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，14： | 1 |
| 17 | Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs显示文摘 | Solberg R Enot D Deigner H P | 2010 | PLo S One2010，5，3： | 1 |
| 18 | Hierarchical metabolomics demonstrates substantial compositional similarity be- tween genetically modified and conventional potato crops 显示文摘 | Catchpole G S Beckmann M Enot D P | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
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