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| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 5 | Divalproex sodium vs placebo for the treatment of irritability in children and adolescents with autism spectrum disorders显示文摘 | Eric H William C Latha S | 2010 | Neuropsychopharmacology2010，35，： | 1 |
| 6 | Predictors of systolic and diastolic improvement in patients with dilated cardiomyopathy treated with metoprolol 显示文摘 | ERIC J E CHRISTIAN M H RICHARD C | 1995 | J Am coll cardiol1995，25，1： | 1 |
| 7 | Natural otolith microstructure patterns reveal precise homingto natal incubation sites by sockeye salmon(oncorhynchus Nerka)显示文摘 | Quinn T P Eric C V Andrew P H | 1999 | Can J Zool1999，77，： | 1 |
| 8 | Dy∶YAG phosphor coating using the solution precursor plasma spray process显示文摘 | DIAN Y C ERIC H J MICHAEL W R | 2009 | Journal of the American Ceramic Society2009，92，1： | 1 |
| 9 | Redox signaling loops in the unfolded protein response显示文摘 | Arisa H Eric C | 2012 | Cellul Signal2012，24，8： | 1 |
| 10 | Network phase in ABC triblock copolymers 显示文摘 | Thomes H E Eric W C Cordell M H | 2004 | Macromolecules2004，37，： | 1 |
| 11 | Proteomic analysis of the peritrophic matrix from the gut of the caterpillar, Helicov erpaarmigera显示文摘 | Peter M C Anh T C Eric R H | 2008 | Insect Biochem Mol Biol2008，38，： | 1 |
| 12 | Effect of Magnetic Hysteresis on Rotational Losses in Heteropolar Magnetic Bearings显示文摘 | David C Meeker Alexei V Filatov and Eric H | 2004 | IEEE Transactions on Magnetics2004，40，5： | 1 |
| 13 | Solid state reduction of a natural il- menite 显示文摘 | Kucukkaragoz C S Eric R H | 2006 | Minerals Engineering2006，19，： | 1 |
| 14 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 15 | Redox signaling loops in the unfolded protein response显示文摘 | Arisa H Eric C | 2012 | Cell Signal2012，24，8： | 1 |
| 16 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 17 | Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors 显示文摘 | Antoinette R Tan Eric H Rubin Diana C Walton | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 18 | A review of the safety of cold pasteurization 14 through irradiation显示文摘 | Lester M C Eric H R | 1996 | Food Control1996，7，2： | 1 |
| 19 | Dynamic modeling of a rigid-flexible manipulator for constrained motion task control显示文摘 | Shi Z X Eric H K Fung Y C | 1999 | Applied Mathematical Modeling1999，23，4： | 1 |
| 20 | Allelic losses at 1p36 and 19q13 in gliom as:corerlation with histologic classification,definition of a 150-kb minimal deleted region on 1p36,and evaluation of CAMTA1 as a candidate tumor suppressor gene显示文摘 | Violetta B Paulo S Eric C H | | 0，，03： | 1 |
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