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| 1 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 2 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008，18，10： | 17 |
| 3 | Robotic distal pancreatectomy versus conventional laparoscopic distal pancreatectomy: a comparative study for short-term outcomes显示文摘机器的系统逐渐地在 pancreatectomy 被使用了。然而,这个方法的有效性仍然保持不明确。这研究比较了在帮助机器人的 laparoscopic 之间的外科的结果远侧的 pancreatectomy 和常规 laparoscopic 远侧的 pancreatectomy。在一个 15 年的时期期间, 35 个病人在我们的中心经历了远侧的 pancreatectomy 的最低限度地侵略的途径。十七个这些病人有帮助机器人的 laparoscopic 途径,并且留下 18 有的常规 laparoscopic 途径。他们的起作用的参数和 perioperative 结果在一个未来的数据库回顾地被分析。在机器的组(221.4 min ) 的吝啬的操作时间在 laparoscopic 组(173.6 min ) 比那显著地长(P = 0.026 ) 。机器、常规的 laparoscopic 组没处于脾保藏率(52.9%对38.9%)介绍重要差别( P = 0.505 ),起作用的血损失( 100.3 ml 对 268.3 ml )( P = 0.29 ),全面病态率(47.1%对38.9%)( P = 0.73 ),并且手术后的医院停留( 11.4 天对 14.2 天)( P = 0.46 )。两个组也没显示出 perioperative 死亡。类似的结果在机器的远侧的 pancreatectomy 和常规 laparoscopic 途径被观察。然而,机器的途径趋于有更少的血损失和更短的医院停留的优点。进一步的研究是必要的决定机器的远侧的 pancreatectomy 的临床的位置。 | Eric C. H. Lai Chung Ngai Tang | 2015 | Frontiers of Medicine2015，9，3： | 8 |
| 4 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 5 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 6 | STABILITY FOR IMPOSING ABSORBING BOUNDARY CONDITIONS IN THE FINITE ELEMENT SIMULATION OF ACOUSTIC WAVE PROPAGATION*显示文摘人工的边界条件为无界的领域上的 wavefields 的有效、精确的计算是关键的,是著名的。在这份报纸,我们调查稳定性分析因为波浪方程结合了吸收边界条件的第一和第二份订单。计算计划也被开发。途径允许吸收边界条件自然地被强加,它使让我们为吸收边界条件构造高顺序计划更容易。一第三 -- 有集体 lumping 的顺序 Lagrange 有限元素方法被使用获得波浪方程的空间 discretization。产生计划是稳定的并且自从没有矩阵倒置被需要在,是很有效的每次走。而且,我们为充分分离的计划显示出抽象、明确的有条件的稳定性结果。结果对在计算设计计算参数有用。数字计算被说明显示出我们的方法的效率和精确性。特别地,实质上,没有边界思考在人工的边界被看见。[从作者抽象] | Wensheng Zhang Eric T. Chung Chaowei Wang | 2014 | Journal of Computational Mathematics2014，32，1： | 4 |
| 7 | Laparoscopic approach of surgical treatment for primary hepatolithiasis: a cohort study显示文摘 | Eric C.H. Lai Tang Chung Ngai George P.C. Yang Michael K.W. Li | 2010 | The American Journal of Surgery2010，，5： | 4 |
| 8 | Robot-assisted laparoscopic liver resection for hepatocellular carcinoma: short-term outcome显示文摘 | Eric C.H. Lai George P.C. Yang Chung Ngai Tang | 2013 | The American Journal of Surgery2013，，6： | 3 |
| 9 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 10 | Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants显示文摘Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy. | Byung Min Chung Eric Tom Neha Zutshi Timothy Alan Bielecki Vimla Band Hamid Band | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 11 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 12 | 一种考虑物理过程信息的油气渗流深度学习新模型显示文摘目前机器学习仍属于纯数据驱动下的单一数据学习,其结果和学习过程的物理可解释性有待提高。在油气田开发中,井网密度较小,井点数据属于稀疏训练样本数据,即使采用深度学习,其预测效果仍欠佳。油气流动物理过程一般较为明确,即满足渗流方程,将渗流方程作为约束条件加入深度学习损失函数项,建立一种考虑物理过程信息的油气渗流深度学习新模型。通过单相和两相流算例验证模型的正确性和高效性。结果表明:在数据样本充足情况下,无论是传统模型还是新建模型均能获得良好的学习和预测效果;随着数据样本的减少,传统模型的学习和预测结果误差也随之增大,但新建模型仍能保持较高精度,即使在强非均质和注采关系反转条件下也能保证预测精度。 | 黄朝琴 年凯 王斌 巩亮 胡慧芳 张世明 CHUNG Eric | 2020 | 中国石油大学学报(自然科学版)2020，44，4： | 3 |
| 13 | Robot-assisted laparoscopic pancreaticoduodenectomy versus open pancreaticoduodenectomy – A comparative study显示文摘 | Eric C.H. Lai George P.C. Yang Chung Ngai Tang | 2012 | International Journal of Surgery2012，，9： | 2 |
| 14 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 2 |
| 15 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 16 | Bladder paraganglioma: A report of case series and critical review of current literature显示文摘Extra-adrenal chromaffin cell-related tumours or paragangliomas are rare, especially in the bladder. In this article, we reported three different clinical cases of bladder paraganglioma, followed by a review of current literature on the pathophysiology and management of bladder paraganglioma. Case 1 involved a 23 years old female patient who complained of a 10-year history of micturition-related headaches, palpitations and diaphoresis; while in case 2, a 58 years old female patient presented with history of painless haematuria and an incidentally diagnosis of a functioning paraganglioma during endoscopic transurethral resection of bladder tumour; and lastly in case 3, a 54 years old male renal transplant recipient was referred to the urology outpatient with a suspicious bladder mass found incidentally on routine transplant workshop. | Matheesha Ranaweera Eric Chung | 2014 | World Journal of Clinical Cases2014，2，10： | 2 |
| 17 | The new 6^(th) edition of the WHO Laboratory Manualfor the Examination and Processing of HumanSemen: is it a step toward better standard operatingprocedure?显示文摘Semen analysis(SA)remains the cornerstone of male infertility evaluation and should ideally be performed by an accredited andrology laboratory or in vitro fertilization(IVF)clinics based on the standards defined by the World Health Organization(WHO)for the Examination and Processing of Human Semen and in accordance with the International Organization for Standardization’s Basic Semen Examination on Specification and Test Methods. | Eric Chung Mohamed Arafa Florence Boitrelle Hussein Kandil Ralf Henkel Ramadan Saleh Rupin Shah Paraskevi Vogiatzi Armand Zini Ashok Agarwal | 2022 | Asian Journal of Andrology2022，24，2： | 2 |
| 18 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | 2010 (9742)2010，，9742： | 2 |
| 19 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 1 |
| 20 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 1 |
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