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| 1 | 美国结直肠外科医师协会2019版藏毛窦诊治临床实践指南显示文摘美国结直肠外科医师协会(The American Society of Colon and Rectal Surgeons,ASCRS)于2019年2月公布了最新的藏毛窦诊治临床实践指南。指南是由国际知名结直肠外科专家组成的临床实践指南委员会修订,对藏毛窦的一些争议进行了汇总和分析。 | Eric K.Johnson,M.D. Jon D.Vogel,M.D. Michelle L.Cowan,M.D. Daniel L.Feingold,M.D. Scott R.Steele,M.D.,M.B.A. 杜涛 张振宇 冷株赟 傅传刚 | 2019 | 结直肠肛门外科2019，25，4： | 23 |
| 2 | Role of terpenes from aphid-infested potato on searching and oviposition behavior of Episyrphus balteatus显示文摘应付病原体和昆虫攻击,植物开发防卫的不同机制,在两个直接(物理、化学) 并且间接方法(到食虫的 beneficials 的吸引人的 volatiles ) 。植物当时能表示由吸引草食动物食肉动物便于害虫的“自顶向下”的控制的特点。这里,我们由分析不稳定的模式调查土豆植物的间接防卫机制健康并且 aphid-infestedplants。在由 Myzus persicae 的射出的萜烯模式的重要变化大批出没于寄植物被观察。用稳固的阶段 MicroExtraction (SPME ) 和 GCMS,(E)-beta-farnesene (EBF ) 看起来被大批出没于蚜虫的土豆并且不由健康植物射出。为了在蚜虫以后估计这些不稳定的版本的 theinfochemical 角色,在 aphidophagous predatorsEpisyrphus balteatus 上损坏, hover 苍蝇 foraging 行为用观察员 5.0 软件被估计(Noldus, Wageningen,荷兰) 。没有蚜虫的土豆植物也被用作控制在食肉动物的不稳定的来源行为的学习。当大批出没于蚜虫的植物导致了有效寻找并且公认字义行为导致时生蛋,健康土豆植物的 kairomonal 效果都没被观察,在网笼子导致更长的不动持续时间和更短的寻找时期。E 的 Highoviposition 率。当大批出没于蚜虫的土豆被使用时, balteatus 被观察(每放并且每 48.9eggs 意味着女性) 。在另一方面,没有鸡蛋被 hover 苍蝇在 healthyaphid 免费的植物上生产。E。balteatus foraging 和繁殖行为在综合蚜虫害虫管理在与 activeinfochemical 分子的潜在的使用的关系根据从大批出没于蚜虫的植物的不稳定的排放被讨论。 | NICOLAS HARMEL RAKI ALMOHAMAD MARIE-LAURE FAUCONNIER PATRICK DU JARDIN FRANCOIS VERHEGGEN MICHEL MARLIER ERIC HAUBRUGE FREDERIC FRANCIS | 2007 | Insect Science2007，14，1： | 11 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 5 | Impact of Metformin on the Prognosis of Cirrhosis Induced by Viral Hepatitis C in Diabetic Patients显示文摘 | Gisèle Nkontchou Emmanuel Cosson Mounir Aout Amel Mahmoudi Valérie Bourcier Iliass Charif Nathalie Ganne-Carrie Véronique Grando-Lemaire Eric Vicaut Jean-Claude Trinchet Michel Beaugrand | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，8： | 3 |
| 6 | Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon:impact of more than 13 years of ivermectin显示文摘Background:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon,including Bilomo and Kelleng.We sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin(CDTI).Methods:Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January 2018.Epilepsy was diagnosed using a 2-step approach:administration of a standardized 5-item questionnaire followed by confirmation by a neurologist.Previously published diagnostic criteria for onchocerciasis-associated epilepsy(OAE)were used.Ov16 serology was done for children aged 7-10 years to assess onchocerciasis transmission.Findings were compared with previous data from these two villages.Results:A total of 1525 individuals(1321 in Bilomo and 204 in Kelleng)in 233 households were surveyed in both villages.The crude prevalence of epilepsy was 4.6%in Bilomo(2017)and 7.8%in Kelleng(2018),including 12(15.6%of cases)persons with epilepsy(PWE)with nodding seizures.The age and sex-standardized prevalence in Kelleng decreased from 13.5%in 2004 to 9.3%in 2018(P<0.001).The median age of PWE shifted from 17(IQR:12-22)years to 24(IQR:20-30)years in Bilomo(P<0.001);and slightly from 24(IQR:14-34)years to 28(IQR:21.25-36.75)years in Kelleng(P=0.112).Furthermore,47.6%of all tested children between 7 and 10 years had Ov16 antibodies.Conclusions:There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both villages.The age-shift observed in PWE suggests that ivermectin may prevent OAE in younger residents.Ov16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control measures.Our findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs. | Joseph Nelson Siewe Fodjo Godwin Tatah Earnest Njih Tabah Leonard Ngarka Leonard Njamnshi Nfor Samuel Eric Chokote Michel KMengnjo Fidele Dema Aurelien Tele Sitouok Grace Nkoro Felicien ENtone Anne-Cecile Zoung-Kanyi Bissek Cedric BChesnais Michel Boussinesq Robert Colebunders Alfred K.Njamnshi | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 7 | 手控与靶控输注瑞芬太尼用于自主呼吸患者的比较研究显示文摘背景丙泊酚和瑞芬太尼联合输注用于保留自主呼吸患者的深度镇静时常常会发生一些副反应,尤其是呼吸抑制。这些副反应的产生可能与药物的组合以及给药技术有关。靶控输注(TCI)可能会优化给药方法。因此,在这项对择期结肠镜检术患者进行的前瞻性随机双盲研究中,我们试图回答以下两个问题:第一,使用丙泊酚的同时加用瑞芬太尼是否利大于弊。第二,与手控输注相比,靶控输注瑞芬太尼是否可以减少副反应的发生。方法接受择期结肠镜检术的患者被随机分组:接爱手控持续输注瑞芬太尼细(MCI)(0.125μg·kg^-1·min^-1的速度持续输注2分钟后改为0.05μg·kg^-1·min^-1的速度持续输注),靶控输注瑞芬太尼组(TCI)(1ng/ml),或安慰剂组(生理盐水靶控输注或以相应的速度手控持续输注)。所有患者都接受丙泊酚靶控输注,调整靶浓度至相应水平使得患者处于深度镇静、对语言指令无反应的同时保留自主呼吸且不需要辅助通气。结果安慰剂组发生沐动、咳嗽和呃逆、暂时干扰检查操作的人数显著多于研究绍、各组间血流动力学和苏醒指标没有显著临床差异.靶控输注瑞芬太尼减少了丙泊酚的用量。使用瑞芬太尼时,靶控输注组(TCI)与手控输注组(MCI)相比,呼吸减弱和呼吸暂停的发生率明显减低(TCI:n=7,MCI:n=16,P〈0.05).结论瑞芬太尼和丙泊酚联合应用于保留自主呼吸的深度镇静时比单独丙泊酚能提供更好的结肠镜检术条件与手控输注瑞芩太尼相比,靶控输注瑞芬太昆可以减少丙泊酚的用量并减少呼吸暂停和呼吸抑制的发生率(TCI:n=7,MCI:n=16,P〈0.05). | Annelies T. Moerman Luc L. Herregods Martine M. De Vos Eric P. Mortier Michel M. R. F. Struys 蒋琦亮(译) 吴镜湘(校) 徐美英(校) | 2010 | 麻醉与镇痛2010，，1： | 3 |
| 8 | Argon Plasma Coagulation Therapy Versus Topical Formalin for Intractable Rectal Bleeding and Anorectal Dysfunction After Radiation Therapy for Prostate Carcinoma显示文摘 | Eric Yeoh William Tam Mark Schoeman James Moore Michelle Thomas Rochelle Botten Addolorata Di Matteo | 2013 | International Journal of Radiation Oncology, Biol2013，，： | 3 |
| 9 | 国际子午圈计划的科学挑战和观测系统显示文摘随着科技发展,人类活动对地面基础设施、空间系统和太空飞行器等高科技设施的依赖性日益增强.然而,这些高科技设施却常常遭受着来自太阳活动、地震、大气和气候变化、地磁场变化,以及全球电场波动等多种危害的威胁.监测和了解这些危害,并减轻其影响,是21世纪重要的科学挑战之一.这些危害尽管形式不同,但是有一个共同之处是会在电离层和中高层大气这个地球空间环境的关键圈层留下自己的印记.国际子午圈计划是一项由中国科学院牵头的国际大科学计划,其目标是整合、部署和运行一个全球研究和监测网络,充分利用电离层和中高层大气的'显示屏'效果来追踪这些日地空间危害的踪迹.文章展示了国际子午圈计划全球观测系统所需的位置分布,即优先沿120°E~60°W大子午圈部署监测设备,实现对主要地理和地磁纬度变化的最佳覆盖,继而辅之以30°E~150°W的第二个子午圈来捕捉经度变化.而后简单地描述了中国子午工程,以及横跨中国、俄罗斯和美洲的一些国家在内的120°E~60°W大子午圈上的监测台站和设备. | 刘维宁 Michel BLANC 王赤 Eric DONAVAN John FOSTER Mark LESTER Hermann OPGENOORTH 任丽文 | 2021 | 中国科学:地球科学2021，51，12： | 3 |
| 10 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 11 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 12 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 13 | Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors显示文摘 | Alain Roche Baragur V. Girish Thierry de Baère Eric Baudin Valérie Boige Dominique Elias Philippe Lasser Martin Schlumberger Michel Ducreux | 2003 | European Radiology2003，，1： | 2 |
| 14 | A role for peroxisome proliferator‐activated receptor gamma in resveratrol‐induced colon cancer cell apoptosis显示文摘 | Virginie Aires Bertrand Brassart Annie Carlier Alessandra Scagliarini Stéphane Mandard Emeric Limagne Eric Solary Laurent Martiny Michel Tarpin Dominique Delmas | 2014 | Mol. Nutr. Food Res2014，，9： | 2 |
| 15 | Fungal antioxidant pathways promote survival against neutrophils during infection显示文摘 | Leal Sixto M Vareechon Chairut Cowden Susan Cobb Brian A Latgé Jean-Paul Momany Michelle Pearlman Eric | 2012 | EN2012，，7： | 2 |
| 16 | Phosphorus Fractionation and Short-term Mobility in the Surface Sediment of a Polymictic Shallow Lake Treated with a Low Dose of Alum (Courtille Lake, France)显示文摘 | Eric van Hullebusch Franck Auvray Véronique Deluchat Philippe M. Chazal Michel Baudu | 2003 | Water Air and Soil Pollution (-)2003，，1： | 1 |
| 17 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 18 | Wholeplant carbon relations and root respiration associated with root tolerance to high soil temperature for Agrostis grasses显示文摘 | Lyons Eric M Pore John DaCosta Michelle Huang Bingru | 2007 | Environmental and Experimental Botany2007，59，： | 1 |
| 19 | Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance显示文摘 | Jonathan W. Weinsaft Han W. Kim Dipan J. Shah Igor Klem Anna Lisa Crowley Rhoda Brosnan Olga G. James Manesh R. Patel John Heitner Michele Parker Eric J. Velazquez Charles Steenbergen Robert M. Judd Raymond J. Kim | 2008 | Journal of the American College of Cardiology2008，，2： | 1 |
| 20 | Predictors of Mitral Regurgitation Recurrence in Patients With Heart Failure Undergoing Mitral Valve Annuloplasty显示文摘 | Agnieszka Ciarka Jerry Braun Victoria Delgado Michel Versteegh Eric Boersma Robert Klautz Robert Dion Jeroen J. Bax Nico Van de Veire | 2010 | The American Journal of Cardiology2010，，： | 1 |
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