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| 1 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | The 10 Traits of Top Salespeople显示文摘 | Erika P | | 0，，01： | 1 |
| 4 | Opening the doors of the intensive care unit to cancer patients: A current perspective显示文摘The introduction of new treatments for cancer and advances in the intensive care of critically ill cancer patients has improved the prognosis and survival. In recent years, the classical intensive care unit(ICU) admission comorbidity criteria used for this group of patients have been discouraged since the risk factors for death that have been studied, mainly the number and severity of organic failures, allow us to understand the determinants of the prognosis inside the ICU. However, the availability of intensive care resources is dissimilar by country, and these differences are known to alter the indications for admission to critical care setting. Three to five days of ICU management is warranted before making a final decision(ICU trial) to consider keep down intensive management of critically ill cancer patients. Nowadays, taking into account only the diagnosis of cancer to consider ICU admission of patients who need full-supporting management is no longer justified. | Silvio A ?amendys-Silva Erika P Plata-Menchaca Eduardo Rivero-Sigarroa Angel Herrera-Gómez | 2015 | World Journal of Critical Care Medicine2015，4，3： | 1 |
| 5 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 6 | Effects of orexins on energy balance and thermoregulation显示文摘 | Miklós S Erika P Márta B | 2002 | Regul Pept2002，104，： | 1 |
| 7 | Selective packet dropping for VolP and TCP flows显示文摘 | Erika P Alvarez-Flores Juan J | 2011 | Telecommun Syst2011，46，： | 1 |
| 8 | Determination of the surface characteristics of particulate fillers by inverse gas chromatography at infinite dilution:a critical approach显示文摘 | ERIKA F J(A)NOS M B(E)LA P | 2004 | J Colloid Interface Sci2004，269，1： | 1 |
| 9 | Prospective, Randomized, Multicenter, Double-Blind Placebo-Controlled Trial Comparing Adjuvant Interferon Alfa and Isotretinoin With Interferon Alfa Alone in Stage IIA and IIB Melanoma: European Cooperative Adjuvant Melanoma Treatment Study Group显示文摘 | Erika R Soyer H P | 2005 | J Clin Oncol2005，12，23： | 1 |
| 10 | Azithromycinand ciprofloxacin resistance in Salmonella bloodstream infectionsin cambodian adults 显示文摘 | ERIKA R V THONG P BIRGIT D S | 2012 | Salmonella Resistance inCambodia2012，6，12： | 1 |
| 11 | Hepcidin,a urinary antimierobial peptide synthesized in the liver显示文摘 | CHRISTINA H P ERIKA V V ALAN J W | 2001 | Biologieal Chemistry2001，276，11： | 1 |
| 12 | Anti-Ids in Allergy : timeliness of a classic concept显示文摘 | JULIA W ISABELLA P S ERIKA J J | 2010 | The World Allergy Organization Journal2010，3，： | 1 |
| 13 | Chemical study of tritm'penoid resinous malerials in archaeological findings by means of direct ex- posure electron ionisation mass spectrometry and gas chromatogra- phy/mass spectrometry显示文摘 | Francesca M Erika R Maria P C | 2006 | Rapid Comm Mass SP2006，20，11： | 1 |
| 14 | Kinetics of interme- tallic phase formation at tile interface of Sn-Ag-Cu-X(X =Bi, ln) solders with Cu substrate显示文摘 | Erika H Maridn P Emil L | 2011 | Journal of Al- loys and Compounds2011，509，： | 1 |
| 15 | Passing to India: a critique of American football's expansion显示文摘 | ERIKA P ERIN W | 2014 | Media Culture Society July2014，36，5： | 1 |
| 16 | Influence ofthe chemical composition of silica - alumina adsorbents in sulfurand nitrogen compounds removal from hydrotreated diesel 显示文摘 | Erika B Silveira Andre L H Costa Joana M P F Silva | 2014 | Industrial & Engineering Chemistry Research2014，53，41： | 1 |
| 17 | Studies on the stability of turmeric constituents显示文摘 | Erika P Simone H Aniko M S | 2003 | J Food Eng2003，56，： | 1 |
| 18 | Aging of the elastic and collagen fibers in the human cervical interspinous ligaments显示文摘 | Erika M.K.P Barros Consuelo J Rodrigues Nilson R Rodrigues Reginaldo P Oliveira Tarcisio E.P Barros Aldo J Rodrigues | 2002 | The Spine Journal2002，，： | 1 |
| 19 | Response of the Had- GEM2 earth system model to future greenhouse gas e- missions pathways to the year 2300显示文摘 | Caesar J Erika P Spencer L | 2013 | Journal of Cli- mate2013，26，10： | 1 |
| 20 | Prospective, randomized, multi- center, double 2 blind placebo 2 controlled trial comparing ad- juvant interferon alfa and isotretinoin with interferon alfa alone in stage IIA and liB melanoma: European cooperative adjuvant melanoma treatment study group显示文摘 | Erika R Soyer H P | 2005 | J Clin Oncol2005，12，23： | 1 |
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