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| 1 | Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells显示文摘Enzymes 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 and-4(PFKFB-3 and PFKFB-4)play a significant role in the regulation of glycolysis in cancer cells as well as its proliferation and survival.The expression of these mRNAs is increased in malignant tumors and strongly induced in different cancer cell lines by hypoxia inducible factor(HIF)through active HIF binding sites in promoter region of PFKFB-4 and PFKFB-3 genes.Moreover,the expression and hypoxia responsibility of PFKFB-4 and PFKFB-3 was also shown for pancreatic(Panc1,PSN-1,and MIA PaCa-2)as well as gastric(MKN45 and NUGC3)cancer cells.At the same time,their basal expression level and hypoxia responsiveness vary in the different cells studied:the highest level of PFKFB-4 protein expression was found in NUGC3 gastric cancer cell line and lowest in Panc1 cells,with a stronger response to hypoxia in the pancreatic cancer cell line.Overexpression of different PFKFB in pancreatic and gastric cancer cells under hypoxic condition is correlated with enhanced expression of vascular endothelial growth factor(VEGF)and Glut1 mRNA as well as with increased level of HIF-1αprotein.Increased expression of different PFKFB genes was also demonstrated in gastric,lung,breast,and colon cancers as compared to corresponding nonmalignant tissue counterparts from the same patients,being more robust in the breast and lung tumors.Moreover,induction of PFKFB-4 mRNA expression in the breast and lung cancers is stronger than PFKFB-3mRNA.The levels of both PFKFB-4 and PFKFB-3 proteins in non-malignant gastric and colon tissues were more pronounced than in the non-malignant breast and lung tissues.It is interesting to note that Panc1and PSN-1 cells transfected with dominant/negative PFKFB-3(dnPFKFB-3)showed a lower level of endogenous PFKFB-3,PFKFB-4,and VEGF mRNA expressions as well as a decreased proliferation rate of these cells.Moreover,a similar effect had dnPFKFB-4.In conclusion,there is strong evidence that PFKFB-4 and PFKFB-3 isoenzymes are induced under hypoxia in pancreatic and other cancer cell lines,are overexpressed in gastric,colon,lung,and breast malignant tumors and undergo changes in their metabolism that contribute to the proliferation and survival of cancer cells.Thus,targeting these PFKFB may therefore present new therapeutic opportunities. | Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi | 2014 | World Journal of Gastroenterology2014，20，38： | 17 |
| 2 | Surface Activities of Calix [4]resorcinarenes Bearing Four Hydrophobic Chains and Its Solubilization for Organic Compounds显示文摘Calix resorcinarenes bearing four hydrophobic side chains ( Ar-Rn, Ar-Ph, and Ar-N) orient stably on water oil interface and show high solubilization capacities for organic compounds, such as long chain alcohols, benzene, toluene and dyes. The capacities are high even near the cmc of polyalkylated calix resorcinarenes, but the solubilities of organic compounds(solubilizates) decrease with the increase of the size of the solubilizates. Ar-R 6, with a chain length of six carbons, is the most effective among Ar-R n , Ar-Ph, and Ar-N; 11 fold mol of hexanol is dissolved in 2×10 -3 mol/L Ar-R 6. Moreover, Ar-R n bearing four alkyl side chains solubilizes the chain alcohols of the same chain length mostly. The solubilization capacities are presumably brought by inclusion in a large cavity of the polyalkylated calix resorcinarenes and by an efficient orientation of the solubilizates. | LI Bo *1 , Yoshifumi KOIDE 1 and Kunio ESUMI 21. Toyota Central R & D Labs., Inc., 41 1, Yokomichi, Nagakute, Aichi 480 1192, Japan 2. Departemnt of Applied Chemistry and Institute of Colloid and Interface Science, Science University of Tokyo | 2002 | Chemical Research in Chinese Universities2002，18，2： | 3 |
| 3 | Placental transfer, lacteal transfer and plasma protein binding of gemcitabine 显示文摘 | Mitsugi K Seki H | 1994 | Xenobiotica1994，24，10： | 1 |
| 4 | Chemical treatment of carbon nanotubes 显示文摘 | Esumi K Ishigami M Nakajima A | 1996 | Carbon1996，34，2： | 1 |
| 5 | Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF 显示文摘 | Esumi N Budarf M Ciccarelli L | 1998 | Mamm Genome1998，9，9： | 1 |
| 6 | Conserved gene structure and genomie linkage for D-dopaehrom tautomerase(DDT)and MIF显示文摘 | Esumi N Budarf M Ciccarelli L | 1998 | Mamm Genome1998，9，9： | 1 |
| 7 | Prevention of hepatitis C virus infection in a chimpanzee by vaccination and epitope mapping of antiserum directed against hypervariable region 1显示文摘 | Nishimura S Esumi M | 2001 | Hepatol Res2001，19，3： | 1 |
| 8 | Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis显示文摘 | Kimura H Esumi H | 2003 | Acta Biochimica Polonica2003，50，1： | 1 |
| 9 | Adsorption characteristics of cationic surfactants on titanium dioxide with quaternary ammonium groups and their adsolubilization 显示文摘 | Kunio Esumi Akihiro Toyoda | 1998 | Jourmal of Colloid and Interface Science1998，202，： | 1 |
| 10 | Antioxidant-potentiality of gold-chitosan nanoeomposites显示文摘 | Esumi K Takei N Yoshimura T | 2003 | Colloids and Surfaces B2003，32，2： | 1 |
| 11 | Preparation of PA-MAM-and PPI-Metal (silver,platinum,and palladium) ano-composites and their eatalytic activities for reduction of 4-Nitrophenol显示文摘 | ISONO R YOSHIMURA T | 2004 | Langmuir2004，，20： | 1 |
| 12 | Interactions between surfactants and particles : dispersion, surface modification,and adsolubilization显示文摘 | ESUMI K | 2001 | Journal of Colloid and Interface Science2001，241，1： | 1 |
| 13 | Isolation of LEAFY and TER- MINAL FLOWER 1 homologues from six fruit tree species in the subfamily Maloideae of the Rosaceae 显示文摘 | ESUMI T TAO R YONEMORI K | 2005 | Sexual Plant Reproduc- tion2005，17，6： | 1 |
| 14 | Synthesis and catalytic activity of gold-silver binary nanoparticles stabilized by PAMAM dendrimer显示文摘 | Endo T Yoshimura T Esumi K | 2005 | J Colloid Interf Sci2005，286，2： | 1 |
| 15 | Isolation of LEAFY and TERMINAL FLOWER 1 homologues from six fruit tree species in the subfamily Maloideae of the Rosaceae显示文摘 | ESUMI T TAO R YONEMORI K | 2005 | Sexual Plant Reproduction2005，17，6： | 1 |
| 16 | Preparation and catalytic activity of Au-Pd,Au-Pt,and PtPd binary metal dendrimer nanocomposites显示文摘 | Endo T Kuno T Yoshimura T Esumi K | 2005 | Journal of Nanoscience and Nanotechnology2005，5，： | 1 |
| 17 | Aqueous dispersion behavior of drug particles by addition of surfactant and polymer显示文摘 | Hideo Terayama Kumiko Okumura Kenichi Sakai Kanjiro Torigoe Kunio Esumi | 2001 | Colloids and Surfaces B: Biointerfaces2001，，1： | 1 |
| 18 | Temporal and spatial expression of LEAFY and TERMINAL FLOWER 1 homologues in floral bud of Japanese pear and quince显示文摘 | ESUMI T TAO R YONEMORI K | 2006 | HortScience2006，，41： | 1 |
| 19 | Efficientsynthesis of isoplagiochin D, a macrocyclic bis (bibenzyls), by utilizing an intramolecular Suzuki- Miyaura reaction 显示文摘 | ESUMI T WADA M MIZUSHIMA E | 2004 | Tetrahedron lett2004，45，37： | 1 |
| 20 | Preparation and characterization of bimetallic palladium-copper colloids bv thermal decomposition of their acetate compounds in organic solvents 显示文摘 | Esumi K Tano T Torigoe K | 1990 | Chem Mater1990，2，5： | 1 |
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