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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Role of STIM1 in neurodegeneration显示文摘STIM1 is an endoplasmic reticulum(ER) protein with a key role in Ca^(2+)mobilization. Due to its ability to act as an ER-intraluminal Ca^(2+) sensor, it regulates store-operated Ca^(2+) entry(SOCE), which is a Ca^(2+) influx pathway involved in a wide variety of signalling pathways in eukaryotic cells. Despite its important role in Ca^(2+) transport, current knowledge about the role of STIM1 in neurons is much more limited. Growing evidence supports a role for STIM1 and SOCE in the preservation of dendritic spines required for long-term potentiation and the formation of memory. In this regard, recent studies have demonstrated that the loss of STIM1, which impairs Ca^(2+) mobilization in neurons, risks cell viability and could be the cause of neurodegenerative diseases. The role of STIM1 in neurodegeneration and the molecular basis of cell death triggered by low levels of STIM1 are discussed in this review. | Carlos Pascual-Caro Noelia Espinosa-Bermejo Eulalia Pozo-Guisado Francisco Javier Martin-Romero | 2018 | World Journal of Biological Chemistry2018，9，2： | 3 |
| 3 | Entropy for intuitionistic fuzzy sets显示文摘 | Eulalia Szmidt Janusz Kacprzyk | 2001 | Fuzzy Sets and Systems2001，，3： | 2 |
| 4 | Distances between intuitionistic fuzzy sets显示文摘 | Eulalia Szmidt Janusz Kacprzyk | 2000 | Fuzzy Sets and Systems2000，，3： | 2 |
| 5 | Entropy for intuitionistic fuzzy sets显示文摘 | Eulalia Szm idt Janusz Kacprxyk | 2001 | Fuzzy Sets and Systems2001，35，4： | 1 |
| 6 | Entropy for intuitionistic fuzzy sets 显示文摘 | Eulalia Szmidt Janusz Kacprxyk | 2001 | Fuzzy Sets and Systems2001，35，4： | 1 |
| 7 | An Interview with Matthew Lipman显示文摘 | Eulalia Bosch | 1998 | Analytic Teaching1998，18，1： | 1 |
| 8 | Increased expression of the renin_angiotensin system and mast cell density but not of angiotensin_converting enzyme Ⅱ in late stages of human heart failure 显示文摘 | Montserrat BA Eulalia RO Felix PE | 2006 | J Heart and Lung Transplant2006，25，9： | 1 |
| 9 | Trans-Resveratrol,a Natural Antioxidant from Grapes,In-creases Sperm Output in Healthy Rats显示文摘 | Juan Emilia Gonzalez-Pons Eulalia Munuera | 2005 | Journal of Nu-trition2005，135，4： | 1 |
| 10 | Determination of flame emissivity in hydrocarbon pool fires using infrared thermograph显示文摘 | Eulalia Planas Cuchi Carlos Lopez Josep Amaldos | 2003 | Fire Technology2003，，26： | 1 |
| 11 | On Separability of Intuitionistic Fuzzy Sets显示文摘 | Atanassov Krassimir T Kacprzyk Janusz Szmidt Eulalia | 2003 | Lecture Notes in Artificial Intelligence2003，2715，： | 1 |
| 12 | On separability of intuitionistic fuzzy sets显示文摘 | Atanassov Krassimir T Kacprzyk Janusz Szmidt Eulalia | 2003 | Lecture Notes in Artificial Intelligence2003，2715，： | 1 |
| 13 | Mobili- zers Mobilized: Information, Expression, Mobilization and Par- ticipation in the Digital Age 显示文摘 | Hemando Rojas Eulalia Puig - i - Abril | 2009 | Computer - Mediated Com- munication2009，，14： | 1 |
| 14 | Origin of trisomy 21 in Down syndrome case from a Spanish population registry显示文摘 | David G Eulalia S Miriam G | 2000 | Annales de Genetique2000，43，： | 1 |
| 15 | Rejection after conversion to a proliferation signal inhibitor in chronic heart transplantation显示文摘 | Francisco González‐Vílchez José A. Vázquez de Prada María J. Paniagua Luis Almenar Sonia Mirabet Manuel Gómez‐Bueno Beatriz Díaz‐Molina Jose M. Arizón Juan Delgado Félix Pérez‐Villa María G. Crespo‐Leiro Luis Martínez‐Dolz Eulalia Roig Javier Segovia José | 2013 | Clin Transplant2013，，6： | 1 |
| 16 | How to Measure the Amount of Knowledge Conveyed by Atanassov's Intuitionistic Fuzzy Sets显示文摘 | Eulalia Szmidt Janusz Kacprzyk Pawel Bujnowski | | 0，，： | 1 |
| 17 | On Separability of Intuitionistic Fuzzy Sets 显示文摘 | Atanassov Krassimir T Janusz K Eulalia S | 2003 | Lecture Notes in Artificial Intelligence2003，2715，： | 1 |
| 18 | Entropy for intuitionistic fuzzy sets显示文摘 | Szmidt Eulalia Kacprzyk J | 2001 | Fuzzy Sets and Systems2001，118，3： | 1 |
| 19 | Fire and explosion hazards during filling/emptying of tanks 显示文摘 | EULALIA P C JUAN A V JOAQUIN C | 1999 | Journal of Loss Prevention in the Process Industries1999，12，： | 1 |
| 20 | Entropy for Intuitionistic Fuzzy Sets显示文摘 | Eulalia S Kacprzyk J | 2001 | Fuzzy Sets and Systems2001，118，： | 1 |
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