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| 1 | Does the root to shoot ratio show a hormetic response to stress? An ecological and environmental perspective显示文摘Root/shoot(R/S)ratio is an important index for assessing plant health,and has received increased attention in the last decades as a sensitive indicator of plant stress induced by chemical or physical agents.The R/S ratio has been discussed in the context of ecological theory and its potential importance in ecological succession,where species follow different strategies for above-ground growth for light or below-ground competition for water and nutrients.We present evidence showing the R/S ratio follows a biphasic dose–response relationship under stress,typical of hormesis.The R/S ratio in response to stress has been widely compared among species and ecological succession classes.It is constrained by a variety of factors such as ontogeny.Furthermore,the current literature lacks dose-response studies incorporating the full dose–response continuum,hence limiting scientific understanding and possible valuable application.The data presented provide an important perspective for new-generation studies that can advance current ecological understanding and improve carbon storage estimates by R/S ratio considerations.Hormetic response of the R/S ratio can have an important role in forestry for producing seedlings with desired characteristics to achieve maximum health/productivity and resilience under plantation conditions. | Evgenios Agathokleous Regina G.Belz Mitsutoshi Kitao Takayoshi Koike Edward J.Calabrese | 2019 | Journal of Forestry Research2019，30，5： | 5 |
| 2 | Forest management required for consistent carbon sink in China’s forest plantations显示文摘Background:Forest is the largest biomass carbon(C)pool in China,taking up a substantial amount of atmospheric carbon dioxide.Although it is well understood that planted forests(PFs)act as a large C sink,the contribution of human management to C storage enhancement remains obscure.Moreover,existing projections of forest C dynamics suffer from spatially inconsistent age and type information or neglected human management impacts.In this study,using developed PF age and type maps and data collected from 1371 forest plantation sites in China,we simulated biomass C stock change and quantified management impacts for the time period 2010-2050.Results:Results show that future forest biomass C increment might have been overestimated by 32.5%-107.5% in former studies.We also found that age-related growth will be by far the largest contributor to PF biomass C increment from 2010 to 2050(1.23±0.002 Pg C,1 Pg=10^(15) g=1 billion metric tons),followed by the impact of human management(0.57±0.02 Pg C),while the contribution of climate is slight(0.087±0.04 Pg C).Besides,an additional 0.24±0.07 Pg C can be stored if current PFs are all managed by 2050,resulting in a total increase of 2.13±0.05 Pg C.Conclusions:Forest management and age-related growth dominate the biomass C change in PFs,while the effect of climatic factors on the accumulation is minor.To achieve the ambitious goal of forest C stock enhancement by 3.5 Pg from 2020 to 2050,we advocate to improve the management of existing forests and reduce the requests for more lands for forest expansion,which helps mitigate potential conflicts with agricultural sectors.Our results highlight that appropriate planning and management are required for sustaining and enhancing biomass C sequestration in China’s PF. | Zhen Yu Weibin You Evgenios Agathokleous Guoyi Zhou Shirong Liu | 2021 | Forest Ecosystems2021，8，4： | 3 |
| 3 | Cytokine gene polymorphisms and graft-versus-host disease in children after matched sibling hematopoietic stem cell transplantation:a single-center experience显示文摘Various polymorphisms in cytokine genes have recently been investigated as candidate risk factors in allogeneic hematopoetic stem cell transplantation(allo-HSCT).We retrospectively analyzed specific polymorphisms in genes for interleukin(IL)-10,IL-6,tumor-necrosis factor alpha(TNF-α)and interferon gamma(IFN-c)in a pediatric cohort of 57 histocompatibility leucocyte antigen(HLA)-identical sibling myeloablative transplants.Both recipient and donor genotypes were tested for association with graft-versus-host disease(GVHD)by statistical methods including Cox regression analysis.We found a significant association between the IL-10 promoter haplotype polymorphisms at positions-1082,-819 and-592 with the occurrence of severe(grades Ⅲ–Ⅳ)acute GVHD(aGVHD).Recipients with the haplotype GCC had a statistically significant decreased risk of severe aGVHD(hazard risk(HR)50.20,95% confidence interval(CI):0.06–0.67)in comparison with patients with other IL-10 haplotypes(P50.008).Transplant-related mortality at 1 year was significantly lower in recipients with this haplotype(HR50.17,95% CI:0.012–0.320)versus other IL-10 haplotypes(P=0.03),whereas overall survival was not influenced by IL-10 haplotype polymorphisms.In multivariate analysis,the presence of the IL-10 GCC haplotype was found as the only variable associated with a statistically significant decreased hazard of severe aGVHD development(P=0.02,HR50.21,95% CI:0.05–0.78).These results suggest that pediatric patients possessing the IL-10 GCC haplotype may be protected from the occurrence of severe aGVHD in the setting of matched sibling HSCT. | Evgenios Goussetis Ioanna Varela Ioulia Peristeri Vasiliki Kitra Kleopatra Spanou Olga Moraloglou Anna Paisiou Sofia Karatasaki Alexandra Soldatou Nikki Constantinidou Stelios Graphakos | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 4 | Ozone disrupts the communication between plants and insects in urban and suburban areas:an updated insight on plant volatiles显示文摘Plant-insect interactions are basic components of biodiversity conservation.To attain the international Sustainable Development Goals(SDGs),the interactions in urban and in suburban systems should be better understood to maintain the health of green infrastructure.The role of ground-level ozone(0_(3)) as an environmental stress disrupting interaction webs is presented.Ozone mixing ratios in suburbs are usually higher than in the center of cities and may reduce photosynthetic productivity at a relatively higher degree.Consequently,carbon-based defense capacities of plants may be suppressed by elevated 0_(3) more in the suburbs.However,contrary to this expectation,grazing damages by leaf beetles have been severe in some urban centers in comparison with the suburbs.To explain differences in grazing damages between urban areas and suburbs,the disruption of atmospheric communication signals by elevated 0_(3) via changes in plant-regulated biogenic volatile organic compounds and long-chain fatty acids are considered.The ecological roles of plant volatiles and the effects of 0_(3) from both a chemical and a biological perspective are presented.Ozone-disrupted plant volatiles should be considered to explain herbivory phenomena in urban and suburban systems. | Noboru Masui Evgenios Agathokleous Tomoki Mochizuki Akira Tani Hideyuki Matsuura Takayoshi Koike | 2021 | Journal of Forestry Research2021，32，4： | 2 |
| 5 | Regularization networks and support vector machines显示文摘 | Evgenio T Pontil M Poggio T | 2000 | Advances in Computational Mathematics2000，，13： | 1 |
| 6 | thylenediurea(EDU)effects on Japanese larch:an one growing season experiment with simulated regenerating communities and a four growing season application to individual saplings显示文摘Japanese larch(Larix kaempferi(Lamb.)Carr.)and its hybrid are economically important coniferous trees widely grown in the Northern Hemisphere.Ground-level ozone(O_(3))concentrations have increased since the preindustrial era,and research projects showed that Japanese larch is susceptible to elevated O_(3)exposures.Therefore,methodologies are needed to(1)protect Japanese larch against O_(3)damage and(2)conduct biomonitoring of O_(3)in Japanese larch forests and,thus,monitor O_(3)risks to Japanese larch.For the first time,this study evaluates whether the synthetic chemical ethylenediurea(EDU)can protect Japanese larch against O_(3)damage,in two independent experiments.In the first experiment,seedling communities,simulating natural regeneration,were treated with EDU(0,100,200,and 400 mg L^(-1))and exposed to either ambient or elevated O_(3)in a growing season.In the second experiment,individually-grown saplings were treated with EDU(0,200 and 400 mg L-1)and exposed to ambient O_(3)in two growing seasons and to elevated O_(3)in the succeeding two growing seasons.The two experiments revealed that EDU concentrations of 200-400 mg L^(-1)could protect Japanese larch seedling communities and individual saplings against O_(3)-induced inhibition of growth and productivity.However,EDU concentrations≤200 mg L^(-1)did offer only partial protection when seedling communities were coping with higher level of O_(3)-induced stress,and only 400 mg EDU L^(-1)fully protected communities under higher stress.Therefore,we conclude that among the concentrations tested the concentration offering maximum protection to Japanese larch plants under high competition and O_(3)-induced stress is that of 400 mg EDU L^(-1).The results of this study can provide a valuable resource of information for applied forestry in an O_(3)-polluted world. | Evgenios Agathokleous Mitsutoshi Kitao Xiaona Wang Qiaozhi Mao Hisanori Harayama William JManning Takayoshi Koike | 2021 | Journal of Forestry Research2021，32，5： | 1 |
| 7 | Regularization networks and support vector machines显示文摘 | T Evgenio M Pontil T Poggio | 2000 | Advances in Computational Mathematics2000，，13： | 1 |
| 8 | Th1-and Th2-type lymphokine-assisted induction and release of chemokine receptors from primary human trophoblast cells显示文摘 | Irene A Lina P Evgenios K | 2000 | J Human Immunology2000，61，： | 1 |
| 9 | Extracorporeal photopheresis in the treatment of chronic graft-versus-host disease. The Hellenic experience: A study by the Hellenic association of hematology显示文摘 | Panagiotis Tsirigotis Panayotis Kaloyannidis Apostolia Papalexandri Ioannis Baltadakis Dimitrios Karakasis Ioannis Batsis Ioanna Sakellari Vassiliki Kitra Evgenios Goussetis Sotirios Papageorgiou Alexandros Spyridonidis Stelios Graphakos Nikolaos Harhalak | 2011 | Transfusion and Apheresis Science2011，，2： | 1 |
| 10 | Demographic changes in China’s forests from 1998 to 2018显示文摘Background: Tree demography is an essential indicator of various forest ecosystem services, and understanding its changes is critical for the sustainable management of forests. During the past four decades, China implemented unprecedented forest restoration projects, which altered tree demography by increasing the number of trees and introducing new species. However, it remains unclear how species composition has changed in China in response to the past forest restoration and demographical processes.Methods: We applied Forest Stability Index(FSI) and the relative change of FSI(%FSI) to describe the population dynamics of tree species and structure in China since 1998, using field-survey data collected from over 200,000plot-records from the 6th to 9th National Forest Inventories(NFIs).Results: The overall populations of both natural and planted forests have grown rapidly from 1998 to 2018, while the range of changes in the relative tree density was more variable for natural forests(ranging from-8.53% to42.46%) than for planted forests(ranging from-1.01% to 13.31%). The populations declined only in some of the tree species, including Betula platyphylla, Ulmus pumila, and Robinia pseudoacacia. In contrast, the populations of trees in the largest size-class either remained stable or expanded.Conclusions: Tree density of China?s forests(both natural and planted forests) generally expanded and the overall populations increased in most size classes, with greater increases occurred in planted forests. In contrasting to the global decline trends of large diameter trees, here we found no apparent decline for trees in the largest size-class in China, highlighting China?s success in improving forest health and forest adaptations to climate change. We advocate for more studies to reveal the mechanisms of the changes in tree demography, which will help to improve forest ecosystem services such as the carbon sequestration capacity. | Yanli Dong Evgenios Agathokleous Shirong Liu Zhen Yu | 2023 | Forest Ecosystems2023，10，1： | 1 |
| 11 | Temperature-induced hormesis in plants显示文摘Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress. To investigate these, dose–response relationships should be clarified. It was previously assumed that the fundamental nature of biological dose–responses follows a linear model, either with no threshold or with a threshold below which no effects are expected to occur in biological endpoints. However, substantial literature, including widespread documentation in plants, has revealed that hormesis commonly occurs. Hormesis is highly generalized and can be utilized as a quantitative measure of biological plasticity. Conditioning induced by adaptive responses also occurs in the framework of hormesis and is of particular importance to environmental change biology with regards to evolutionary adaptations.This paper presents additional evidence for hormetic dose responses induced by temperature in plants. The current understanding on hormesis provides a perspective for next generation environmental change research. Hormesis should have a central role in environmental change biology of vegetation. | Evgenios Agathokleous Mitsutoshi Kitao Hisanori Harayama Edward J.Calabrese | 2019 | Journal of Forestry Research2019，30，1： | 1 |
| 12 | Ethylenediurea(EDU)effects on hybrid larch saplings exposed to ambient or elevated ozone over three growing seasons显示文摘Ground-level ozone(O_(3))pollution is a persistent environmental issue that can lead to adverse effects on trees and wood production,thus indicating a need for forestry interventions to mediate O_(3) effects.We treated hybrid larch(Larix gmelinii var.japonica×L.kaempferi)saplings grown in nutrient-poor soils with 0 or 400 mg L^(-1) water solutions of the antiozonant ethylenediurea(EDU0,EDU400)and exposed them to ambient O_(3)(AOZ;08:00-18:00≈30 nmol mol^(-1)) or elevated O_(3)(EOZ;08:00-18:00≈60 nmol mol^(-1))over three growing seasons.We found that EDU400 protected saplings against most effects of EOZ,which included extensive visible foliar injury,premature senescence,decreased photosynthetic pigment contents and altered balance between pigments,suppressed gas exchange and biomass production,and impaired leaf litter decay.While EOZ had limited effects on plant growth(suppressed stem diameter),it decreased the total number of buds per plant,an effect that was not observed in the first growing season.These results indicate that responses to EOZ might have implications to plant competitiveness,in the long term,as a result of decreased potential for vegetative growth.However,when buds were standardized per unit of branches biomass,EOZ significantly increased the number of buds per unit of biomass,suggesting a potentially increased investment to bud development,in an effort to enhance growth potential and competitiveness in the next growing season.EDU400 minimized most of these effects of EOZ,significantly enhancing plant health under O_(3)-induced stress.The effect of EDU was attributed mainly to a biochemical mode of action.Therefore,hybrid larch,which is superior to its parents,can be significantly improved by EDU under long-term elevated O_(3) exposure,providing a perspective for enhancing afforestation practices. | Evgenios Agathokleous Mitsutoshi Kitao Takayoshi Koike | 2022 | Journal of Forestry Research2022，33，1： | 1 |
| 13 | Emerging challenges of ozone impacts on asian plants:actions are needed to protect ecosystem health显示文摘Context:Ozone concentrations near the land surface are rising in Asia while they are declining or stagnating in Europe and North America.Ozone is the most widespread air pollutant negatively affecting vegetation,and its increased concentrations pose a major threat to food quality and production and other ecosystem services in Asia.Method:In this review,we provide an overview of scientific challenges in the impacts of ozone pollution on Asian vegetation,and synthesize the challenges toward mitigation of the impacts.Result:We argue that new policy initiatives need to seek both reduction of ozone levels and enhancement of plant tolerance to ozone to maintain food quality and ensure food supplies.Conclusion:The scientific advancements must be transferred to actions by two types of institutions:a)environmental agencies for reducing ozone levels and b)agricultural research institutions for enhancing plant tolerance to ozone.In connecting the scientific advancements with the institutional actions,scientists in Asian countries should play the key role taking advantages of interdisciplinary and international collaborations. | Zhaozhong Feng Evgenios Agathokleous Xu Yue Elina Oksanen Elena Paoletti Hiroyuki Sase Anthony Gandin Takayoshi Koike Vicent Calatayud Xiangyang Yuan Xuejun Liu Alessandra De Marco Yves Jolivet Sari Kontunen-Soppela Yasutomo Hoshika Hikaru Saji Pin Li Zhengzhen Li Makoto Watanabe Kazuhiko Kobayashi | 2021 | Ecosystem Health and Sustainability2021，7，1： | 1 |
| 14 | 新丝路、新视野、新机遇——中国房地产和物业管理投资发展论坛互动交流显示文摘改革开放40年,我国房地产和物业管理为发展经济、改善人居、创造美好生活作出了突出的贡献。当前,房地产企业处在转型升级中。十九大报告提出,我国对外开放正面向新时代、踏上新征程,而 一带一路'是我国企业走出国门迈向新市场,扩大投资并深化与世界各国合作的历史契机。为落实十九大精神,致敬改革开放40周年,本次中国房地产和物业管理投资发展论坛举办了以'新丝路、新视野、新机遇'为主题的互动论坛,探寻新时代企业商业模式和发展路径。 | 陈朝晖 Vassilis Xiros Evgenios Tassopoulos Grant King Richard Barrett 杜昊益 | 2018 | 城市开发2018，0，7： | 0 |
| 15 | Effect size in papers published by the Journal of Forestry Research:A missing treasure?显示文摘P values based on standard hypothesis testing are commonly reported in articles published by the Journal of Forestry Research(JFR).However,effect sizes are barely used and reported,even if they are of direct relevance to the primary questions of many of the published studies.The incorporation of effect sizes in studies published by JFR should be encouraged and promoted.Inclusion of effect sizes as a requirement in the journal guidelines will facilitate a major change in the way data are tested and interpreted,with the ultimate goal to exempt researchers from the custom of drawing conclusions merely based upon a dichotomous statistical result(P value).Such a policy can also lead to more informed decisions of whether identified effects are of practical relevance to the forestry. | Evgenios Agathokleous Lei Yu | 2023 | Journal of Forestry Research2023，34，2： | 0 |
| 16 | Sensitivity of forest phenology in China varies with proximity to forest edges显示文摘Background:Shifts in forest phenological events serve as strong indicators of climate change.However,the sensitivity of phenology events to climate change in relation to forest origins has received limited attention.Moreover,it is unknown whether forest phenology changes with the proximity to forest edge.Methods:This study examined the green-up dates,dormancy dates,time-integrated NDVI(LiNDVI,a measure of vegetation productivity in growing season),and their sensitivities to climatic factors along the gradients of distance(i.e.proximity)to forest edge(0–2 km)in China's natural forests(NF)and planted forests(PF).For the analysis,field-surveyed data were integrated with Moderate Resolution Imaging Spectroradiometer(MODIS)NDVI from 2000 to 2022.Results:Our results reveal that PF had earlier green-up dates,later dormancy dates,and higher LiNDVI than NF.However,green-up sensitivities to temperature were higher at the edges of NF,whereas no such pattern was observed in PF.Conversely,the sensitivity of dormancy dates remains relatively stable from the inner to the edge of both NF and PF,except for a quadratic change in dormancy date sensitivity to precipitation found in NF.Additionally,we found that the green-up sensitivity to temperature increased with decreasing proximity to edge in NF evergreen forests,while it showed the opposite trend in PF evergreen forests.Furthermore,we observed that the precipitation impact on green-up dates shifts from postponing to advancing from the inner to the edge of NF,whereas precipitation dominantly postpones PF's green-up dates regardless of the proximity to edge.The LiNDVI exhibits higher sensitivity to precipitation at the edge areas,a phenomenon observed in NF but not in PF.Conclusions:These results suggest that the responses of forests to climate change vary with the distance to the edge.With increasing edge forests,which results from fragmentation caused by global changes,we anticipate that desynchronized phenological events along the distance to the edge could alter biogeochemical cycles and reshape ecosystem services such as energy flows,pollination duration,and the tourism industry.Therefore,we advocate for further investigations of edge effects to improve ecosystem modelling,enhance forest stability,and promote sustainable tourism. | Weibin You Ziyi Xian Guoyi Zhou Evgenios Agathokleous Zhen Yu | 2023 | Forest Ecosystems2023，10，6： | 0 |
| 17 | Pseudoangiomatous squamous cell carcinoma:a challenge for pathologists and plastic surgeons显示文摘Pseudo-angiosarcomatous or pseudovascular squamous cell carcinoma(SCC)of the skin is an unusual variant form of acantholytic SCC that mimics the histopathological appearance of angiosarcoma.We describe a case of pseudovascular SCC in a 77-year-old lady to highlight the frequent recurrence and aggressiveness,as well as the clinicopathological features of this rare form of cutaneous SCC,and demonstrate the difficulties in establishing the correct diagnosis.Plastic surgeons involved in the care of patients with cutaneous malignancies should be aware of this variant of SCC and its aggressive nature in order to manage these patients appropriately. | Dimitrios Kanakopoulos Evgenios Evgeniou Panayiotis A.Dimitriadis Mahendra Kulkarni | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 18 | Ozone pollution threatens bird populations to collapse:an imminent ecological threat?显示文摘While bird populations are declining,the factors associated with this decline are unclear.Based on laboratory experiments,air pollution has long been recognized as a factor causing oxidative stress and adversely aff ecting bird health.Recently,studies employing an epidemiological approach have reported signifi cant declines in avian populations in Central Europe and the United States due to air pollution,and ozone in particular.We advocate that urgent actions are needed to mitigate these eff ects,which threaten biodiversity and environmental health,and propose a series of measures which can enlighten the path toward mitigating air pollution eff ects on avian populations. | Evgenios Agathokleous Pierre Sicard Zhaozhong Feng Elena Paoletti | 2023 | Journal of Forestry Research2023，34，6： | 0 |
| 19 | Elevated CO2 offsets the alteration of foliar chemicals(n-icosane,geranyl acetate,and elixene)induced by elevated O3 in three taxa of O3-tolerant eucalypts显示文摘Eucalypts are important forest resources in southwestern China,and may be tolerant to elevated ground-level ozone(O3)concentrations that can negatively affect plant growth.High CO2 may offset O3-induced effects by providing excess carbon to produce secondary metabolites or by inducing stomatal closure.Here,the effects of elevated CO2 and O3 on leaf secondary metabolites and other defense chemicals were studied by exposing seedlings of Eucalyptus globulus,E.grandis,and E.camaldulensis×E.deglupta to a factorial combination of two levels of O3(<10 nmol mol^(−1)and 60 nmol mol^(−1))and CO2(ambient:370μmol mol^(−1)and 600μmol mol^(−1))in open-top field chambers.GC-profiles of leaf extracts illustrated the effect of elevated O3 and the countering effect of high CO2 on compounds in leaf epicuticular wax and essential oils,i.e.,n-icosane,geranyl acetate and elixene,compounds known as a first-line defense against insect herbivores.n-Icosane may be involved in tolerance mechanisms of E.grandis and the hybrid,while geranyl acetate and elixene in the tolerance of E.globulus.Elevated O3 and CO2,singly or in combination,affected only leaf physiology but not biomass of various organs.Elevated CO2 impacted several leaf traits,including stomatal conductance,leaf mass per area,carbon,lignin,n-icosane,geranyl acetate and elixene.Limited effects of elevated O3 on leaf physiology(nitrogen,n-icosane,geranyl acetate,elixene)were commonly offset by elevated CO2.We conclude that E.globulus,E.grandis and the hybrid were tolerant to these O3 and CO2 treatments,and n-icosane,geranyl acetate and elixene may be major players in tolerance mechanisms of the tested species. | Eka Novriyanti Qiaozhi Mao Evgenios Agathokleous Makoto Watanabe Yasuyuki Hashidoko Takayoshi Koike | 2021 | Journal of Forestry Research2021，32，2： | 0 |
| 20 | The rise and fall of photosynthesis:hormetic dose response in plants显示文摘The recent recognition that low doses of herbicides,human and veterinary antibiotics,metallic elements,micro/nano-plastics,and various other types of environmental pollutants widely enhance chlorophylls in the framework of hormesis created the need to further evaluate the response of photosynthetic pigments and gas exchange to low doses of stresses.An analysis of about 370 values of maximum stimulatory response(MAX;percentage of control response,%)of chlorophylls in higher plants,algae and duckweeds,and other photosynthesizing organisms,mined from published literatures,revealed a greater MAX for higher plants(median=139.2%)compared to algae and duckweeds(median=119.6%).However,an analysis of about 50 mined values of MAX of carotenoids revealed no signifi-cant difference in the median MAX between higher plants(median=133.0%)and algae-duckweeds(median=138.1%).About 70 mined values of MAX were also concentrated for photosynthetic rate(median MAX=129.2%)and stomatal conductance(median MAX=124.7%)in higher plants.Within higher plants,there was no significant difference in the median MAX among chlorophylls,carotenoids,photosynthetic rate,and stomatal conductance.Similarly,there was no significant difference in the median MAX between chlorophylls and carotenoids of pooled algae and duckweeds.The results suggest that the MAX is typically below 160%and as a rule below 200%of control response,and does not differ among chlorophylls,carotenoids,photosynthetic rate,and stomatal conductance.New research programs with improved experimental designs,in terms of number and spacing of doses within the“low-dose zone”of the hormetic dose–response relationship,are needed to study the molecular/genetic mechanisms underpinning the low-dose stimulation of photosynthesis and its ecological implications. | Evgenios Agathokleous | 2021 | Journal of Forestry Research2021，32，2： | 0 |
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