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| 1 | Purification and Characterization of a New Ribosome Inactivating Protein from Cinchonaglycoside C-treated Tobacco Leaves显示文摘A new ribosome-inactivating protein(RIP)with a molecular weight of 31 kDa induced by Cinchonaglycoside C(1)designatedCLP31,was isolated from tobacco leaves.Analysis of this protein sequence indicated that it belongs to the RIP family and itwas distinct from the other plant RIPs reported previously at its N-terminal amino acid sequence.CIP31 can directly impairsynthesis of coat protein(CP)of tobacco mosaic virus(TMV),which resulted in inhibition of TMV long distance movementand multiplication in tobacco plants at concentrations of ng/mL.Furthermore,no toxicity was shown to the growth andfertility of the plants.CIP31 was synthesized only in the presence of Cinchonaglycoside C(1)and was independent of thesalicylic acid(SA)signal pathway.We provided evidence for the SA-independent biological induction of resistance. | Yanmei Li Yantao Jia Zhongkai Zhang Xiaoying Chen Hongping He Rongxiang Fang Xiaojiang Hao | 2007 | Journal of Integrative Plant Biology2007，49，9： | 8 |
| 2 | SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2显示文摘小核仁的 RNA (snoRNA ) 机能障碍与癌症开发被联系了。SNORD126 是在它的主机基因的 introns 5-6 以内被编码的孤儿 C/D 框 snoRNA, cyclin 交往 B1 蛋白质 1 (CCNB1IP1 ) 。SNORD126 触发的联系癌症的分子的机制充分没被理解。这里,我们证明 SNORD126 高度在 hepatocellular 癌(HCC ) 被表示, colorectal 癌症(CRC ) 病人取样。SNORD126 在裸体老鼠增加了 Huh-7 和 SW480 细胞生长和 tumorigenicity。SNORD126 击倒禁止的 HepG2 和 LS174T 房间生长。我们证实 SNORD126 没与 miRNA 活动被处理成小 RNA。而且, SNORD126 没在 HCC 样品与 CCNB1IP1 显示出重要表示关联或调整 CCNB1IP1 表示。我们的基因表示侧面分析显示了基因经常印射到 PI3K-AKT 小径的那 SNORD126-upregulated。SNORD126 overexpression 增加了 phosphorylated AKT, GSK-3,和 p70S6K 的层次并且提高了成纤维细胞生长因素受体 2 (FGFR2 ) 表示。在 SNORD126-overexpressing Huh-7 细胞的 FGFR2 的调停 siRNA 的击倒或调停 AZD4547 的 inactivation 禁止了 AKT phosphorylation 并且压制了细胞生长。这些调查结果在癌症为 SNORD126 显示一个 oncogenic 角色并且作为一个治疗学的目标建议它的潜力。 | Xianlong Fang Dongmei Yang Hongping Luo Shuai Wu Wenjie Dong Jing Xiao Sujing Yuan Aimin Ni Kang-Jian Zhang Xin-Yuan Liu Liang Chu | 2017 | Journal of Molecular Cell Biology2017，9，3： | 5 |
| 3 | Performance study on T-stub connected semi-rigid joint between rectangular tubular columns and H-shaped steel beams显示文摘This paper investigates the performance of T-stub connected semi-rigid joint of rectangular tubular columns and H-shaped steel beams.The finite element analysis software ABAQUS is used to analyze the nonlinear performance of the joint under monotonic loading.Meanwhile,the dimensions of T-stub,column and beam are considered as analytic parameters to discuss the performance of the joint.The analysis shows that the thickness and the length of T-stub webs,the height of beam section,bolt diameter,shear connector and the preloaded force affect the performance of the joint largely,and the thickness of the steel tube,the thickness and length of T-stub flange,bolt spacing have relatively little influences on the performance of the joint.The research results indicate that this joint is semi-rigid joint. | Guochang LI Hongping YU Chen FANG | 2013 | Frontiers of Structural and Civil Engineering2013，7，3： | 2 |
| 4 | Tm^3+/ Er^3+/Yb^3+-codoped Oxyhalide Tellurite Glasses as Materials for Ghree-dimensional display显示文摘 | Shiqing Xu Hongping Ma Daiwei Fang | 2005 | Materials letters2005，59，2425： | 1 |
| 5 | Performance of non-thermal DBD plasma reactor during the removal of hydrogen sulfide显示文摘 | LIANG Wenjun FANG Hongping LI Jian | 2011 | Journal of Electrostatics2011，69，： | 1 |
| 6 | Tm^3+/Er^3+/Yb^3+ -codoped oxyhalide tellurite glasses as materials for three-dimensional display显示文摘 | Shiqing Xu Hongping Ma Dawei Fang | 2005 | Mater Lett2005，59，： | 1 |
| 7 | Over‐expression of regulator of G protein signaling 5 promotes tumor metastasis by inducing epithelial–mesenchymal transition in hepatocellular carcinoma cells显示文摘 | Minghua Hu Xiaobing Chen Jianmin Zhang Dong Wang Xiaosan Fang Xiaoming Wang Guannan Wang Guoyong Chen Xiaochun Jiang Hongping Xia Yongsheng Wang | 2013 | J Surg Oncol2013，，3： | 1 |
| 8 | MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells显示文摘 | Hongping Xia Yanting Qi Samuel S. Ng Xiaona Chen Shen Chen Marong Fang Dan Li Yu Zhao Ruiguang Ge Guo Li Yangchao Chen Ming-Liang He Hsiang-fu Kung Lihui Lai Marie C. Lin | 2009 | Biochemical and Biophysical Research Communications2009，，2： | 1 |
| 9 | Study on Prestressed Transfer Efficiency and Moment Amplitude Modulation of Steel-Concrete Composite Bridge显示文摘 | Li Yong Fang Qinhan Zhu Hongping | 2011 | Journal of Harbin Institute of Technology2011，，2： | 1 |
| 10 | Energy and electron transfers in photosensitive chitosan 显示文摘 | Wu Shuizhu Zeng Fang Zhu Hongping | 2005 | J Am Chem Soc2005，127，： | 1 |
| 11 | Immunoregulatory and Anti-Tumor Effects of Polysaccharopeptide and Astragalus polysaccharides on Tumor-Bearing Mice显示文摘 | Li Jin Bao Yixi Lam Waikei Li Wenwen Lu Fang Zhu Xuan Liu Jing Wang Hongping | 2008 | Immunopharmacology and Immunotoxicology2008，，4： | 1 |
| 12 | The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models显示文摘Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species(ROS).PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors.The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation,western blotting and Immunohistochemistry.H2O2 was applied to affect the production of ROS and induced multi-resistant protein 1(MRP1)expression in NSCLC cells.The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress.We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues compared to adjacent tissues.The oxidative stress improved the combination of PRDX5 and Nrf2.We demonstrated that the synergy between PRDX5 and Nrf2 is positively related to the proliferation and drug resistance of NSCLC cells in the zebrafish models.In conclusion,our data indicated that PRDX5 could bind to Nrf2 and has a synergistic effect with Nrf2.Meanwhile,in the zebrafish models,PRDX5 and Nrf2 have significant regulatory impacts on lung cancer progression and drug resistance activities under oxidative stress. | SITONG QIAN YING FANG CHENGYUN YAO YONGSHENG WANG ZHI ZHANG XIAOHUA WANG JIN GAO YONG FENG LEI SUN RUNYUE ZOU GUOREN ZHOU JINJUN YE RUIXUE XIA HONGPING XIA | 2022 | Oncology Research2022，30，2： | 0 |
| 13 | A Study on the Underlying Mechanism of the Emergence of Gated Communities in Urban China显示文摘Modern gated communities have emerged in China against a background of socio-economic transition. They are different from the gated communities in western countries in many aspects. In particular, they bear obvious Chinese characteristics in the reasons for their popularity. In order to explore the underlying economic, social, political, and cultural mechanism of the popularity of gated communities in China, this article conducts a comprehensive analysis from many angles by drawing on various theories. It is concluded that the emergence of gated communities in urban China is pushed by the special social relations of production in the period of transition. In particular the social, economic, governmental, and individual powers together promote the emergence and development of gated communities. | Yang Hongping Qian Fang | 2016 | China City Planning Review2016，25，4： | 0 |
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