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| 1 | Positioning accuracy assessment for the 4GEO/5IGSO/2MEO constellation of COMPASS显示文摘Determined to become a new member of the well-established GNSS family,COMPASS(or BeiDou-2) is developing its capabilities to provide high accuracy positioning services.Two positioning modes are investigated in this study to assess the positioning accuracy of COMPASS' 4GEO/5IGSO/2MEO constellation.Precise Point Positioning(PPP) for geodetic users and real-time positioning for common navigation users are utilized.To evaluate PPP accuracy,coordinate time series repeatability and discrepancies with GPS' precise positioning are computed.Experiments show that COMPASS PPP repeatability for the east,north and up components of a receiver within China's Mainland is better than 2 cm,2 cm and 5 cm,respectively.Apparent systematic offsets of several centimeters exist between COMPASS precise positioning and GPS precise positioning,indicating errors remaining in the treatments of COMPASS measurement and dynamic models and reference frame differences existing between two systems.For common positioning users,COMPASS provides both open and authorized services with rapid differential corrections and integrity information available to authorized users.Our assessment shows that in open service positioning accuracy of dual-frequency and single-frequency users is about 5 m and 6 m(RMS),respectively,which may be improved to about 3 m and 4 m(RMS) with the addition of differential corrections.Less accurate Signal In Space User Ranging Error(SIS URE) and Geometric Dilution of Precision(GDOP) contribute to the relatively inferior accuracy of COMPASS as compared to GPS.Since the deployment of the remaining 1 GEO and 2 MEO is not able to significantly improve GDOP,the performance gap could only be overcome either by the use of differential corrections or improvement of the SIS URE,or both. | ZHOU ShanShi CAO YueLing ZHOU JianHua HU XiaoGong TANG ChengPan LIU Li GUO Rui HE Feng CHEN JunPing WU Bin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 31 |
| 2 | Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease显示文摘Parkinson’s disease(PD),known as one of the most universal neurodegenerative diseases,is a serious threat to the health of the elderly.The current treatment has been demonstrated to relieve symptoms,and the discovery of new small-molecule compounds has been regarded as a promising strategy.Of note,the homeostasis of the autolysosome pathway(ALP)is closely associated with PD,and impaired autophagy may cause the death of neurons and thereby accelerating the progress of PD.Thus,pharmacological targeting autophagy with small-molecule compounds has been drawn a rising attention so far.In this review,we focus on summarizing several autophagy-associated targets,such as AMPK,m TORC1,ULK1,IMPase,LRRK2,beclin-1,TFEB,GCase,ERRα,C-Abelson,and as well as their relevant small-molecule compounds in PD models,which will shed light on a clue on exploiting more potential targeted small-molecule drugs tracking PD treatment in the near future. | Kai Zhang Shiou Zhu Jiamei Li Tingting Jiang Lu Feng Junping Pei Guan Wang Liang Ouyang Bo Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 9 |
| 3 | Development of small molecule extracellular signal-regulated kinases(ERKs) inhibitors for cancer therapy显示文摘The mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase 1/2(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its dysregulation is associated with the proliferation, invasion, and migration of cancer cells. ERK1/2 is located at the distal end of this pathway and rarely undergoes mutations, making it an attractive target for anticancer drug development. Currently, an increasing number of ERK1/2 inhibitors have been designed and synthesized for antitumor therapy, among which representative compounds have entered clinical trials. When ERK1/2 signal transduction is eliminated, ERK5 may provide a bypass route to rescue proliferation, and weaken the potency of ERK1/2 inhibitors. Therefore, drug research targeting ERK5 or based on the compensatory mechanism of ERK5 for ERK1/2 opens up a new way for oncotherapy. This review provides an overview of the physiological and biological functions of ERKs, focuses on the structure-activity relationships of small molecule inhibitors targeting ERKs, with a view to providing guidance for future drug design and optimization, and discusses the potential therapeutic strategies to overcome drug resistance. | Xiaoli Pan Junping Pei Aoxue Wang Wen Shuai Lu Feng Faqian Bu Yumeng Zhu Lan Zhang Guan Wang Liang Ouyang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 4 | Effects of imidazolium-based ionic liquids on the isobaric vapor–liquid equilibria of methanol+dimethyl carbonate azeotropic systems显示文摘The separation of methanol(MeOH)and dimethyl carbonate(DMC)is important but difficult due to the formation of an azeotropic mixture.In this work,isobaric vapor–liquid equilibrium(VLE)data for the ternary systems containing different imidazolium–based ionic liquids(ILs),i.e.MeOH+DMC+1-butyl-3-methy-limidazolium bis[(trifluoromethyl)sulfonyl]imide([Bmim][Tf2N]),MeOH+DMC+1-ethyl-3-methyl-imidazolium bis[(trifluoromethyl)sulfonyl]imide([Emim][Tf2N]),and MeOH+DMC+1-ethyl-3-methylimidazolium hexafluorophosphate([Emim][PF6])were measured at 101.3 kPa.The mole fraction of IL was varied from0.05 to 0.20.The experimental data were correlated with the NRTL and Wilson equations,respectively.The results show that imidazolium-based ILs were beneficial to improve the relative volatility of MeOH to DMC,and[Bmim][Tf2 N]showed a much more excellent performance on the activity coefficient of MeOH.The interaction energies of system components were calculated using Gaussian program,and the effects of cation and anion on the separation coefficient of the azeotropic system were discussed. | Songsong Chen Li Dong Junping Zhang Weiguo Cheng Feng Huo Qian Su Wei Hua | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 3 |
| 5 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 6 | Determining antimicrobial resistance profiles and identifying novel mutations of Neisseria gonorrhoeae genomes obtained by multiplexed MinION sequencing显示文摘Gonorrhea is one of the most common sexually transmitted diseases worldwide. To cure infection and prevent transmission,timely and appropriate antimicrobial therapy is necessary. Unfortunately, Neisseria gonorrhoeae, the etiological agent of gonorrhea, has acquired nearly all known mechanisms of antimicrobial resistance(AMR), thereby compromising the efficacy of antimicrobial therapy. Treatment failure resulting from AMR has become a global public health concern. Whole-genome sequencing is an effective method to determine the AMR characteristics of N. gonorrhoeae. Compared with next-generation sequencing, the MinION sequencer(Oxford Nanopore Technologies(ONT)) has the advantages of long read length and portability. Based on a pilot study using MinION to sequence the genome of N. gonorrhoeae, we optimized the workflow of sequencing and data analysis in the current study. Here we sequenced nine isolates within one flow cell using a multiplexed sequencing strategy. After hybrid assembly with Illumina reads, nine integral circular chromosomes were obtained. By using the online tool Pathogenwatch and a BLAST-based workflow, we acquired complete AMR profiles related to seven classes of antibiotics. We also evaluated the performance of ONT-only assemblies. Most AMR determinants identified by ONT-only assemblies were the same as those identified by hybrid assemblies. Moreover, one of the nine assemblies indicated a potentially novel antimicrobial-related mutation located in mtrR which results in a frame-shift, premature stop codon, and truncated peptide.In addition, this is the first study using the MinION sequencer to obtain complete genome sequences of N. gonorrhoeae strains which are epidemic in China. This study shows that complete genome sequences and antimicrobial characteristics of N.gonorrhoeae can be obtained using the MinION sequencer in a simple and cost-effective manner, with hardly any knowledge of bioinformatics required. More importantly, this strategy provides us with a potential approach to discover new AMR determinants. | Chi Zhang Feng Wang Cansheng Zhu Leshan Xiu Yamei Li Li Li Bo Liu Yizhun Li Yaling Zeng Boyang Guo Junping Peng | 2020 | Science China(Life Sciences)2020，63，7： | 2 |
| 7 | Study on the resistance spot welding technology of 22MnMoB hot stamping quenched steel显示文摘In this paper,the spot welding technology of a new kind of 22 MnMoB hot stamping quenched steel sheet was systematically studied by power frequency spot welder.Through a series of technology and test experiments,we have obtained the optimal spot welding technological parameter condition.According to the results,the relations among spot welding technological parameter,welding nugget,mechanical property and fracture mode were discussed.The effects of all the welding parameters such as welding current,welding time and electrode force on the quality of joint can be boiled down to one thing—the diameter of welding nugget.The experimental results showed that welding nugget diameter determines the mechanical property of spot welding joint and the relation between welding nugget diameter and the mechanical property of joint presents a kind of linear mathematic representation.There are two typical fracture models of 22 MnMoB hot stamping quenched steel sheet,i.e.,interfacial fracture and nugget pullout.Other than mild steel or normal high strength steel,in the shearing tensile test,hot stamping quenched steel has a great tendency to fail in interfacial mode due to the effects of high strength matrix structure,welding soft zone and the porosity level of fusion zone. | Feng Yi Ma Mingtu Hua Fu'an Zhang Junping Song Leifeng Jin Qingsheng | 2014 | Engineering Sciences2014，12，5： | 2 |
| 8 | The Browsing Pattern and Review Model of Online Consumers Based on Large Data Analysis显示文摘In the context of online shopping, commodity information and consumer reviews are main factors that will affect purchasing behavior. Started from the preference of commodity information browsing and the inherent property of online reviews, this paper focuses on the browsing data for statistical analysis and the interval distribution of consumer reviews based on the real data of360 buy which is the domestic large-scale B2 C commerce website in China. Researches find that commodity information browsing time distribution on Internet is fragment and can be depicted by the fat tail effect. It also demonstrated that user's browsing patterns are related to the type of information and the displaying of the information,which means that the pieces of the picture and the length of the titles affecting the clicks rate. Reviews on the interval distribution can be depicted by the power-law function and there is a monotonically increasing relationship between power-exponent and the customers' concerns with the corresponding commodity, the higher the exponent,the higher the degree of consumer attention. The finding obtained some basic rules of the browsing mode and review model, which is of important significance for future research. | NING Lianju WANG Haoyu FENG Xin DU Junping | 2015 | Chinese Journal of Electronics2015，24，1： | 2 |
| 9 | Application of the technique of local grooving top-caving with controlled explosion in disposing the abandoned-stope of Dongtongyu Gold Mine显示文摘 | LI Junping FENG Changgen | 2006 | Progress in Safety Science and Technology2006，6，： | 1 |
| 10 | LDTS: A lightweight and dependable trust system for clustered wireless sensor networks显示文摘 | Li Xiaoyong Zhou Feng Du Junping | 2013 | IEEE Translnformation Forensics and Security2013，8，6： | 1 |
| 11 | Analysis to world-class university evaluation methods and results in 2010显示文摘 | Qiu junping Zhao rongying Ma feng Wang feifei | 2010 | Wuhan Daxue Xuebao2010，35，2： | 1 |
| 12 | Phylogenetic, evolutionary, and biogeographic origin of the genus Sheathia (Batrachospermales, Rhodophyta)显示文摘The genus Sheathia consists of over 20 species primarily distributed in Asia,Europe,Oceania,North America,and Africa.However,the origin and evolution of this genus remain unclear.Two gametophyte stage specimens(SAS18052 and SAS18523)and two“Chantransia”stage specimens(YTS19161 and YTS19017)were collected from Shanxi and Henan Provinces in China,respectively.Based on morphological data,isolates YTS19161 and YTS19017 were similar to Audouinella pygmaea,whereas the morphological characteristics of SAS18052 and SAS18523 were in good agreement with the circumscription description of S.longipedicellata.Molecular sequences of rbc L,COI-5P,and psb A were used to investigate the phylogenetic,evolutionary,and biogeographic origin of the genus Sheathia.The three molecular markers supported that the two gametophyte stage specimens belong to S.longipedicellata,while the isolates YTS19161 and YTS19017 were the“Chantransia”of S.longipedicellata.Ancestral area reconstruction and divergence time estimation speculated that Sheathia originated in North America,a portion of the Pangaea at approximately 328.07-184.73 million years ago(Ma).Our relaxed molecular clock analysis suggests that the Florideophyceae diverged approximately 741.04(894.36-631.70)Ma.The major divergences in this class involved the emergence of Nemaliophycidae[ca.662.01(779.83-580.51)Ma],and the split of orders Batrachospermales and Thoreales[ca.456.10(552.80-367.88)Ma]. | Jinfen HAN Fangru NAN Jia FENG Junping LÜ Qi LIU Xudong LIU Shulian XIE | 2022 | Journal of Oceanology and Limnology2022，40，2： | 1 |
| 13 | Transcriptome profile of Dunaliella salina in Yuncheng Salt Lake reveals salt-stress-related genes under diff erent salinity stresses显示文摘Salt stress is an abiotic stress to plants in especially saline lakes.Dunaliella,a halophilic microalga distributed throughout salt lakes and seas,can respond to different salinity stresses by regulating the expression of some genes.However,these genes and their function and biological processes involved remain unclear.Profi ling these salt-stress-related genes in a high-salt-tolerant Dunaliella species will help clarify the salt tolerance machinery of Dunaliella.Three D.salina_YC salt-stress groups were tested under low(0.51 mol/L),moderate(1.03 mol/L),and high(3.42 mol/L)NaCl concentrations and one control group under very low(0.05 mol/L)NaCl concentration and 3 transcriptome results that were deep sequenced and de novo assembled were obtained per group.Twelve high-quality RNA-seq libraries with 46585 upregulated and 47805 downregulated unigenes were found.Relative to the control,188 common differentially expressed genes(DEGs)were screened and divided into four clusters in expression pattern.Fifteen of them annotated in the significant enriched Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)were validated via qPCR.Their qPCR-based relative expression patterns were similar to their RNA-seq-based patterns.Two significant DEGs,the geranylgeranyl diphosphate synthase coding gene(1876-bp cDNA)and diacylglycerol O-acyltransferase coding gene(2968-bp cDNA),were cloned and analyzed in silico.The total lipid content,superoxide dismutase specific activity,and betacarotene content of D.salina_YC increased gradually with increasing salinity.In addition,the expression of 11 validated genes involved in fatty acid biosynthesis/degradation,active oxygen or carotenoid metabolisms showed significant changes.In addition,algal photochemical efficiency was diminished with increasing salinity,as well as the expression of 4 photosynthesis-related genes.These results could help clarify the molecular mechanisms underlying D.salina responses to the Yuncheng Salt Lake environment and lay a foundation for further utilization of this algal resource. | Fan GAO Fangru NAN Jia FENG Junping LÜ Qi LIU Xudong LIU Shulian XIE | 2021 | Journal of Oceanology and Limnology2021，39，6： | 1 |
| 14 | LDTS: A Lightweight and Dependable Trust System for Clustered Wireless Sensor Networks 显示文摘 | XIAOYONG L FENG Z JUNPING D | 2013 | IEEE Transactions on Information Forensics and Security2013，8，6： | 1 |
| 15 | Bifurcation analysis of reaction–diffusion Schnakenberg model显示文摘 | Ping Liu Junping Shi Yuwen Wang Xiuhong Feng | 2013 | Journal of Mathematical Chemistry2013，，8： | 1 |
| 16 | Modeling of the Catalytic Distillation Process for the Synthesis of Dimethyl Carbonate by Urea Methanolysis Method 显示文摘 | Wang Feng Zhao Ning Li Junping | 2007 | Ind Eng Chem Res2007，46，26： | 1 |
| 17 | Affinities offreshwater“Chantransia”stage algae(Rhodophyta)from China based on molecular and morphological analyses显示文摘Twelve putative'Chantransia'isolates were collected from six locations across Hubei,Shanxi,Guizhou,and Henan Provinces in China.Their morphological characters were evaluated via the Ward’s method of hierarchical cluster analysis in SPSS software to classify phylogenetic relationships among the isolates.The morphological data revealed that isolate HN31(called group'MALL')was distinct from the other specimens being macroscopic with large vegetative cells and monosporangia(>20μm in diameter).The 11 other isolates were grouped into three clusters,corresponding to the species Audouinella tenella,A.hermannii,and A.pygmaea.The morphological'Chantransia'stage of the species,reportedly belonging to the orders Batrachospermales,Thoreales,and the phylogenetically distant genus Audouinella,are very similar,resulting in the di fficulty to distinguish them based just on morphology.Therefore,molecular analysis of rbc L,UPA,and COI-5 P was conducted to infer the phylogenetic position of all isolates in this study.All'A.tenella'and'A.hermannii'sequences belong to order Batrachospermales,while the isolate HN31 was the'Chantransia'of Thorea hispida.The six other specimens varied morphologically,but they were within the circumscription of'A.pygmaea'.All three molecular markers show that all'pygmaea'isolates also represent the'Chantransia'of T.hispida.Furthermore,results from this investigation proposed a new species—Sheathia qinyuanensis,corresponding to the isolates QY1 and QY2. | Jinfen HAN Fangru NAN Jia FENG Junping LV Qi LIU Xudong LIU Shulian XIE | 2021 | Journal of Oceanology and Limnology2021，39，3： | 1 |
| 18 | Research on wheelbase preview control for vehicle semi-active suspen-sion based on neural networks 显示文摘 | FENG Junping BEI Sbaoyi YUAN Chuanyi | 2009 | Third International Symposium on Intelligent Information Technology Applica- tion2009，3，： | 1 |
| 19 | Morphology evolution of ZrB 2 nanoparticles synthesized by sol–gel method显示文摘 | Yun Zhang Ruixing Li Yanshan Jiang Bin Zhao Huiping Duan Junping Li Zhihai Feng | 2011 | Journal of Solid State Chemistry2011，，8： | 1 |
| 20 | Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae显示文摘Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in N.gonorrhoeae from clinical samples(Zhang et al.,2021). | Chi Zhang Lulu Zhang Feng Wang Yaling Zeng Liying Sun Di Wang Yamei Li Liqin Wang Junping Peng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
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